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OPENSEQ.org
YDDE - Uncharacterized isomerase YddE
UniProt: P37757 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11825
Length: 297 (295)
Sequences: 1672
Seq/Len: 5.67
YDDE
Paralog alert: 0.27 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
81_Y 287_I 4.146 1.00
224_V 263_G 3.572 1.00
250_R 268_T 3.079 1.00
172_V 176_A 2.96 1.00
31_S 34_Q 2.804 1.00
50_L 79_A 2.793 1.00
60_I 98_S 2.659 1.00
8_V 82_V 2.473 1.00
28_D 52_H 2.454 1.00
170_P 173_D 2.294 1.00
117_S 282_S 2.256 1.00
225_T 228_A 2.256 1.00
59_R 97_T 2.099 1.00
9_D 41_E 2.09 1.00
70_P 99_L 2.08 1.00
210_G 229_N 2.054 1.00
25_F 50_L 1.945 1.00
181_L 220_V 1.944 1.00
10_A 21_A 1.914 1.00
72_C 75_A 1.914 1.00
12_T 286_V 1.898 1.00
7_H 289_F 1.893 1.00
180_D 183_A 1.872 1.00
171_E 175_D 1.868 1.00
13_S 284_T 1.837 1.00
48_A 79_A 1.826 1.00
30_L 38_I 1.809 1.00
14_Q 17_R 1.803 1.00
224_V 265_I 1.785 1.00
119_E 278_K 1.748 1.00
35_M 61_R 1.743 1.00
168_L 173_D 1.703 1.00
71_I 227_N 1.701 1.00
12_T 17_R 1.687 1.00
229_N 253_G 1.682 1.00
21_A 78_A 1.668 1.00
120_Q 230_G 1.647 1.00
4_Q 290_H 1.641 1.00
95_W 102_K 1.641 1.00
105_V 116_I 1.631 0.99
233_G 267_V 1.62 0.99
39_A 47_T 1.596 0.99
62_Y 75_A 1.571 0.99
10_A 78_A 1.553 0.99
36_Q 39_A 1.529 0.99
214_S 219_I 1.516 0.99
34_Q 38_I 1.511 0.99
21_A 72_C 1.508 0.99
32_E 35_M 1.508 0.99
137_I 164_V 1.497 0.99
53_S 97_T 1.494 0.99
252_K 266_E 1.487 0.99
163_K 212_M 1.483 0.99
6_Y 82_V 1.48 0.99
115_R 266_E 1.476 0.99
229_N 265_I 1.476 0.99
183_A 186_A 1.467 0.99
253_G 265_I 1.461 0.99
59_R 99_L 1.458 0.99
265_I 281_I 1.458 0.99
250_R 266_E 1.398 0.98
215_P 219_I 1.386 0.98
233_G 269_V 1.384 0.98
6_Y 290_H 1.367 0.98
62_Y 72_C 1.359 0.97
38_I 293_W 1.357 0.97
19_N 226_G 1.337 0.97
7_H 42_L 1.331 0.97
10_A 62_Y 1.323 0.97
212_M 228_A 1.316 0.97
70_P 163_K 1.315 0.97
254_H 262_D 1.312 0.97
4_Q 292_E 1.303 0.96
257_R 262_D 1.302 0.96
21_A 75_A 1.295 0.96
252_K 264_M 1.29 0.96
139_N 183_A 1.289 0.96
30_L 34_Q 1.282 0.96
169_K 173_D 1.28 0.96
141_L 166_I 1.273 0.96
60_I 79_A 1.271 0.96
61_R 68_E 1.261 0.96
177_L 198_P 1.257 0.95
29_N 51_L 1.243 0.95
147_D 169_K 1.232 0.95
48_A 75_A 1.231 0.95
83_R 87_L 1.226 0.95
42_L 289_F 1.222 0.94
143_L 168_L 1.209 0.94
230_G 281_I 1.205 0.94
45_S 223_P 1.204 0.94
45_S 219_I 1.204 0.94
214_S 218_G 1.195 0.94
7_H 44_H 1.186 0.93
168_L 174_I 1.175 0.93
163_K 195_G 1.172 0.93
98_S 118_L 1.168 0.93
5_V 291_A 1.167 0.92
6_Y 25_F 1.165 0.92
71_I 100_A 1.16 0.92
171_E 209_D 1.157 0.92
268_T 280_T 1.154 0.92
105_V 118_L 1.153 0.92
254_H 264_M 1.152 0.92
46_E 225_T 1.149 0.92
76_T 101_G 1.143 0.91
46_E 75_A 1.132 0.91
104_R 119_E 1.128 0.91
29_N 52_H 1.125 0.91
97_T 102_K 1.125 0.91
69_V 75_A 1.12 0.90
32_E 36_Q 1.117 0.90
21_A 62_Y 1.115 0.90
165_M 235_W 1.113 0.90
62_Y 69_V 1.111 0.90
210_G 253_G 1.106 0.90
80_H 96_Q 1.105 0.90
71_I 103_H 1.104 0.89
17_R 262_D 1.104 0.89
224_V 253_G 1.1 0.89
10_A 72_C 1.093 0.89
8_V 23_V 1.086 0.88
224_V 229_N 1.084 0.88
62_Y 78_A 1.083 0.88
16_F 261_R 1.078 0.88
10_A 75_A 1.067 0.87
167_P 239_H 1.062 0.87
5_V 289_F 1.061 0.87
225_T 232_M 1.061 0.87
20_S 44_H 1.057 0.87
15_P 288_L 1.051 0.86
41_E 261_R 1.049 0.86
158_T 162_S 1.049 0.86
33_A 37_L 1.046 0.86
141_L 177_L 1.044 0.86
9_D 16_F 1.041 0.85
212_M 225_T 1.041 0.85
46_E 223_P 1.038 0.85
62_Y 71_I 1.023 0.84
57_D 102_K 1.018 0.84
214_S 217_I 1.016 0.83
106_T 280_T 1.016 0.83
75_A 78_A 1.013 0.83
25_F 29_N 1.012 0.83
135_A 139_N 1.01 0.83
5_V 42_L 1.01 0.83
256_G 262_D 1.007 0.83
179_P 213_F 1.006 0.83
165_M 232_M 1.005 0.83
36_Q 67_V 1.004 0.82
35_M 51_L 1.002 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qyaA20.99331000.256Contact Map0.714
1ym5A10.95621000.265Contact Map0.669
3ednA20.98321000.271Contact Map0.738
1xubA10.93271000.278Contact Map0.662
1u0kA20.94281000.305Contact Map0.657
1s7jA20.88221000.31Contact Map0.706
4dunA10.88221000.325Contact Map0.721
3ejxA60.91251000.435Contact Map0.489
2gkeA10.87541000.439Contact Map0.504
4juuA20.90241000.443Contact Map0.454
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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