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OPENSEQ.org
ENVC - Murein hydrolase activator EnvC
UniProt: P37690 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12297
Length: 419 (386)
Sequences: 1161
Seq/Len: 3.01
ENVC
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
369_N 387_A 3.682 1.00
333_V 369_N 3.244 1.00
336_I 364_S 2.738 1.00
358_H 364_S 2.721 1.00
96_I 180_L 2.676 1.00
120_Q 159_R 2.637 1.00
310_Y 410_A 2.527 1.00
307_L 326_G 2.526 1.00
356_V 386_I 2.496 1.00
103_I 173_V 2.447 1.00
110_K 166_L 2.384 1.00
300_W 325_I 2.344 1.00
344_A 372_A 2.334 1.00
198_Q 202_T 2.315 1.00
327_A 389_V 2.211 1.00
373_L 388_L 2.209 1.00
338_D 381_R 2.195 1.00
332_E 385_P 2.139 1.00
389_V 400_L 2.107 1.00
309_R 414_Q 2.027 1.00
304_G 325_I 2.002 1.00
98_E 102_S 1.992 1.00
299_F 382_A 1.982 1.00
364_S 404_I 1.922 0.99
89_L 187_Q 1.904 0.99
251_A 255_A 1.893 0.99
113_Q 169_T 1.876 0.99
324_V 401_Y 1.856 0.99
369_N 372_A 1.826 0.99
374_V 378_S 1.819 0.99
47_I 226_L 1.776 0.99
267_E 270_R 1.753 0.99
374_V 384_Q 1.741 0.99
177_R 181_E 1.733 0.99
335_A 356_V 1.731 0.99
257_E 260_A 1.699 0.98
239_S 242_R 1.643 0.98
81_K 197_Q 1.641 0.98
265_Q 268_A 1.625 0.98
100_N 104_A 1.608 0.97
197_Q 200_K 1.602 0.97
92_L 187_Q 1.599 0.97
259_Q 262_R 1.587 0.97
75_I 201_L 1.577 0.97
250_R 254_E 1.575 0.97
340_R 379_Q 1.564 0.97
259_Q 263_D 1.523 0.96
358_H 366_Y 1.523 0.96
350_Y 367_G 1.498 0.96
264_R 268_A 1.496 0.96
246_A 249_A 1.487 0.95
191_L 195_R 1.476 0.95
77_E 81_K 1.476 0.95
324_V 399_S 1.455 0.95
381_R 384_Q 1.443 0.94
324_V 368_Y 1.433 0.94
195_R 198_Q 1.428 0.94
323_M 417_L 1.421 0.94
53_A 56_Q 1.413 0.93
305_P 326_G 1.412 0.93
355_V 363_M 1.406 0.93
336_I 402_F 1.391 0.93
82_L 194_Q 1.389 0.93
362_D 406_R 1.387 0.93
183_K 186_E 1.377 0.92
334_K 385_P 1.37 0.92
295_R 416_W 1.368 0.92
329_E 398_P 1.358 0.92
260_A 263_D 1.351 0.91
92_L 183_K 1.35 0.91
320_W 399_S 1.349 0.91
291_L 362_D 1.344 0.91
125_F 151_Y 1.342 0.91
366_Y 402_F 1.332 0.91
105_K 109_Q 1.331 0.91
336_I 366_Y 1.328 0.90
321_K 403_E 1.327 0.90
174_A 178_A 1.325 0.90
79_T 83_R 1.323 0.90
373_L 387_A 1.32 0.90
308_H 313_Q 1.317 0.90
54_V 226_L 1.302 0.89
320_W 324_V 1.302 0.89
78_A 204_A 1.292 0.89
253_R 256_R 1.288 0.89
308_H 320_W 1.281 0.88
171_E 175_M 1.28 0.88
175_M 179_E 1.276 0.88
102_S 172_E 1.275 0.88
391_S 395_Q 1.275 0.88
266_K 270_R 1.27 0.88
92_L 96_I 1.269 0.88
364_S 402_F 1.268 0.87
266_K 269_T 1.267 0.87
72_E 208_R 1.264 0.87
107_E 111_A 1.262 0.87
95_Q 183_K 1.259 0.87
358_H 402_F 1.259 0.87
323_M 414_Q 1.25 0.86
268_A 271_K 1.243 0.86
322_G 359_G 1.242 0.86
357_E 405_R 1.242 0.86
412_N 415_P 1.241 0.86
375_S 378_S 1.239 0.86
107_E 177_R 1.231 0.85
109_Q 169_T 1.226 0.85
69_K 73_E 1.221 0.85
298_A 416_W 1.218 0.84
61_R 216_E 1.218 0.84
350_Y 403_E 1.205 0.84
320_W 401_Y 1.201 0.83
75_I 82_L 1.187 0.82
96_I 103_I 1.186 0.82
61_R 219_I 1.182 0.82
244_E 247_A 1.182 0.82
75_I 205_L 1.181 0.82
260_A 267_E 1.181 0.82
357_E 361_G 1.179 0.82
228_E 232_N 1.179 0.82
403_E 410_A 1.178 0.82
300_W 417_L 1.164 0.81
245_A 249_A 1.159 0.80
250_R 253_R 1.156 0.80
196_A 200_K 1.15 0.79
38_D 42_S 1.149 0.79
110_K 169_T 1.147 0.79
385_P 388_L 1.143 0.79
78_A 81_K 1.138 0.79
362_D 416_W 1.134 0.78
362_D 404_I 1.129 0.78
342_I 357_E 1.126 0.77
102_S 176_Q 1.123 0.77
167_K 171_E 1.122 0.77
70_K 74_A 1.12 0.77
108_Q 112_A 1.12 0.77
72_E 76_S 1.119 0.77
405_R 410_A 1.118 0.77
411_V 416_W 1.117 0.77
249_A 252_E 1.107 0.76
47_I 51_E 1.1 0.75
368_Y 393_G 1.098 0.75
139_G 148_L 1.098 0.75
61_R 212_L 1.09 0.74
258_A 262_R 1.088 0.74
91_Q 95_Q 1.087 0.74
327_A 331_T 1.087 0.74
209_K 213_A 1.085 0.74
99_M 147_R 1.084 0.74
327_A 330_G 1.084 0.74
298_A 382_A 1.084 0.74
336_I 404_I 1.081 0.73
141_E 144_R 1.077 0.73
291_L 416_W 1.076 0.73
267_E 271_K 1.07 0.72
324_V 397_R 1.068 0.72
111_A 115_R 1.055 0.71
182_E 186_E 1.05 0.70
164_A 168_Q 1.05 0.70
295_R 298_A 1.046 0.70
103_I 177_R 1.046 0.70
110_K 163_I 1.045 0.70
208_R 212_L 1.042 0.69
192_Y 195_R 1.036 0.69
205_L 209_K 1.036 0.69
233_E 237_R 1.034 0.69
48_A 52_R 1.033 0.68
355_V 365_L 1.031 0.68
164_A 167_K 1.031 0.68
354_V 386_I 1.03 0.68
120_Q 124_A 1.028 0.68
304_G 410_A 1.027 0.68
331_T 389_V 1.024 0.67
67_Q 208_R 1.023 0.67
106_L 110_K 1.016 0.67
302_V 327_A 1.009 0.66
74_A 78_A 1.007 0.66
99_M 103_I 1.006 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4bh5A40.33891000.597Contact Map0.82
2hsiA20.65391000.62Contact Map0.799
3tufB10.38421000.628Contact Map0.689
1qwyA10.63961000.647Contact Map0.734
2gu1A10.6851000.65Contact Map0.762
3sluA20.78281000.653Contact Map0.731
3nyyA10.50841000.664Contact Map0.632
3it5A40.29361000.671Contact Map0.57
3csqA40.6421000.697Contact Map0.481
3na7A10.608698.40.906Contact Map0.302
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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