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YIAO - 2,3-diketo-L-gulonate-binding periplasmic protein YiaO
UniProt: P37676 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12283
Length: 328 (303)
Sequences: 3772
Seq/Len: 12.45
YIAO
Paralog alert: 0.60 [within 20: 0.10] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
250_P 253_Q 4.937 1.00
58_E 252_F 4.186 1.00
242_K 246_D 4.099 1.00
249_S 252_F 4.071 1.00
280_D 284_E 3.514 1.00
52_Q 60_K 2.872 1.00
318_A 322_K 2.858 1.00
54_R 258_S 2.851 1.00
254_Q 258_S 2.803 1.00
296_K 300_D 2.758 1.00
138_K 242_K 2.687 1.00
85_D 244_K 2.629 1.00
280_D 283_K 2.545 1.00
178_A 181_K 2.497 1.00
49_D 53_E 2.491 1.00
55_T 255_A 2.47 1.00
245_F 257_V 2.462 1.00
31_G 75_M 2.448 1.00
48_N 52_Q 2.354 1.00
46_K 49_D 2.301 1.00
55_T 59_L 2.234 1.00
50_L 262_E 2.144 1.00
149_D 230_H 2.131 1.00
269_K 273_E 2.12 1.00
45_K 49_D 2.083 1.00
160_P 297_A 2.018 1.00
215_W 281_G 1.961 1.00
27_S 62_K 1.909 1.00
51_L 255_A 1.895 1.00
281_G 284_E 1.895 1.00
244_K 247_G 1.893 1.00
28_L 85_D 1.879 1.00
161_A 164_K 1.874 1.00
48_N 63_L 1.871 1.00
50_L 54_R 1.835 1.00
50_L 53_E 1.824 1.00
178_A 309_M 1.811 1.00
28_L 244_K 1.792 1.00
30_F 61_L 1.767 1.00
195_V 204_I 1.76 1.00
111_R 115_H 1.737 1.00
130_A 133_E 1.714 1.00
54_R 259_S 1.711 1.00
138_K 257_V 1.695 1.00
54_R 255_A 1.695 1.00
47_F 260_A 1.689 1.00
245_F 253_Q 1.67 1.00
273_E 277_K 1.665 1.00
180_F 185_A 1.658 1.00
112_D 115_H 1.656 1.00
121_D 268_R 1.646 1.00
46_K 266_Y 1.622 1.00
155_A 166_L 1.605 1.00
27_S 60_K 1.581 1.00
294_D 297_A 1.578 1.00
126_D 130_A 1.575 1.00
218_K 221_E 1.573 1.00
46_K 50_L 1.556 1.00
32_Y 41_H 1.553 1.00
279_I 283_K 1.539 1.00
250_P 254_Q 1.533 1.00
70_G 78_G 1.528 1.00
58_E 251_E 1.522 1.00
196_Y 222_V 1.506 1.00
300_D 304_N 1.506 1.00
50_L 259_S 1.496 1.00
129_K 139_V 1.496 1.00
133_E 242_K 1.494 1.00
86_M 240_I 1.492 1.00
225_F 288_E 1.483 1.00
100_V 131_S 1.465 1.00
54_R 262_E 1.462 1.00
51_L 256_L 1.458 1.00
297_A 300_D 1.457 1.00
322_K 326_E 1.452 1.00
122_G 125_G 1.439 1.00
59_L 252_F 1.437 1.00
30_F 44_A 1.396 0.99
304_N 308_D 1.387 0.99
49_D 52_Q 1.385 0.99
296_K 299_S 1.382 0.99
79_V 241_N 1.369 0.99
228_L 279_I 1.356 0.99
55_T 252_F 1.354 0.99
196_Y 221_E 1.345 0.99
257_V 261_Q 1.345 0.99
29_R 64_F 1.333 0.99
47_F 51_L 1.332 0.99
277_K 281_G 1.33 0.99
230_H 295_R 1.322 0.99
181_K 187_P 1.318 0.99
281_G 285_A 1.314 0.99
151_T 207_Q 1.311 0.99
243_A 246_D 1.307 0.99
253_Q 257_V 1.305 0.99
51_L 61_L 1.304 0.99
190_M 204_I 1.295 0.99
160_P 298_F 1.295 0.99
26_Q 249_S 1.291 0.99
270_L 273_E 1.285 0.99
276_Q 280_D 1.279 0.99
291_T 294_D 1.267 0.99
71_N 74_A 1.261 0.99
26_Q 252_F 1.258 0.99
258_S 262_E 1.257 0.99
182_V 305_Q 1.254 0.99
190_M 198_G 1.24 0.98
75_M 87_E 1.231 0.98
156_P 225_F 1.231 0.98
266_Y 270_L 1.226 0.98
159_T 162_D 1.218 0.98
151_T 223_Q 1.213 0.98
127_D 323_A 1.212 0.98
168_I 206_A 1.197 0.98
59_L 256_L 1.195 0.98
41_H 45_K 1.188 0.98
37_T 41_H 1.188 0.98
58_E 249_S 1.187 0.98
32_Y 63_L 1.184 0.98
211_I 228_L 1.181 0.98
133_E 138_K 1.167 0.97
207_Q 223_Q 1.164 0.97
117_H 272_A 1.151 0.97
308_D 311_V 1.146 0.97
138_K 246_D 1.141 0.97
28_L 86_M 1.141 0.97
208_E 231_H 1.124 0.97
151_T 214_V 1.124 0.97
240_I 244_K 1.118 0.96
259_S 263_A 1.11 0.96
274_D 277_K 1.109 0.96
282_M 287_V 1.106 0.96
156_P 288_E 1.102 0.96
265_N 269_K 1.102 0.96
48_N 61_L 1.101 0.96
158_K 162_D 1.1 0.96
220_F 285_A 1.099 0.96
36_Q 45_K 1.095 0.96
255_A 259_S 1.094 0.96
64_F 69_L 1.088 0.96
297_A 301_A 1.086 0.96
161_A 297_A 1.083 0.96
152_N 155_A 1.079 0.95
319_D 322_K 1.072 0.95
65_P 68_T 1.065 0.95
30_F 238_V 1.058 0.95
47_F 256_L 1.053 0.95
26_Q 59_L 1.051 0.94
110_F 119_T 1.047 0.94
64_F 68_T 1.038 0.94
31_G 84_I 1.036 0.94
46_K 262_E 1.025 0.93
259_S 262_E 1.006 0.93
197_T 201_T 1.005 0.93
319_D 323_A 1.004 0.93
123_K 323_A 1 0.92
225_F 290_I 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3u65B20.94211000.175Contact Map0.652
2xwvA10.92071000.196Contact Map0.76
2vpnA20.91161000.206Contact Map0.668
2hpgA40.92681000.22Contact Map0.771
3fxbA20.95431000.223Contact Map0.631
4n4uA20.96651000.234Contact Map0.725
2pfyA40.90851000.235Contact Map0.753
4napA40.91461000.25Contact Map0.75
2pfzA10.90851000.254Contact Map0.716
2hzlA20.98781000.294Contact Map0.692
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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