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YIAN - 2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN
UniProt: P37675 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12282
Length: 425 (417)
Sequences: 3697
Seq/Len: 8.87
YIAN
Paralog alert: 0.62 [within 20: 0.08] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_M 182_G 4.326 1.00
320_M 364_N 3.856 1.00
127_R 133_V 3.753 1.00
229_G 235_F 3.341 1.00
260_T 263_T 3.023 1.00
311_S 314_L 2.837 1.00
179_M 183_A 2.717 1.00
160_G 167_I 2.713 1.00
184_T 406_L 2.65 1.00
309_V 314_L 2.596 1.00
321_V 325_I 2.56 1.00
397_F 401_L 2.512 1.00
150_I 178_G 2.436 1.00
80_D 215_S 2.434 1.00
156_F 359_V 2.431 1.00
95_Y 186_M 2.391 1.00
90_P 194_S 2.26 1.00
97_G 140_I 2.196 1.00
25_L 284_S 2.166 1.00
320_M 411_V 2.16 1.00
191_W 195_R 2.146 1.00
188_T 402_V 2.135 1.00
134_N 391_D 2.117 1.00
315_L 350_A 2.083 1.00
115_T 381_I 2.073 1.00
95_Y 190_W 2.018 1.00
162_S 336_V 2.017 1.00
211_H 214_V 2.015 1.00
71_A 266_H 2.006 1.00
98_V 189_W 2.001 1.00
315_L 319_I 1.964 1.00
312_P 352_I 1.95 1.00
348_K 354_P 1.947 1.00
401_L 405_S 1.923 1.00
207_Q 211_H 1.923 1.00
408_V 412_F 1.91 1.00
165_L 355_I 1.884 1.00
326_V 335_T 1.876 1.00
163_S 344_M 1.868 1.00
116_A 380_V 1.845 1.00
67_E 270_G 1.834 1.00
94_G 139_L 1.831 1.00
325_I 329_V 1.828 1.00
409_V 413_I 1.796 1.00
316_F 411_V 1.791 1.00
160_G 170_L 1.789 1.00
313_R 317_I 1.788 1.00
85_L 209_I 1.783 1.00
67_E 271_A 1.754 1.00
317_I 321_V 1.745 1.00
388_K 391_D 1.708 1.00
205_T 208_E 1.695 1.00
81_L 213_F 1.679 1.00
347_V 357_F 1.677 1.00
315_L 347_V 1.669 1.00
335_T 365_C 1.666 1.00
176_A 416_L 1.662 1.00
138_G 395_G 1.66 1.00
206_M 209_I 1.65 1.00
262_A 265_W 1.64 1.00
192_Q 196_L 1.632 1.00
269_I 273_K 1.61 1.00
253_T 259_M 1.601 1.00
4_L 8_G 1.6 1.00
187_L 191_W 1.588 1.00
106_S 114_D 1.583 1.00
173_A 417_I 1.578 1.00
184_T 402_V 1.576 1.00
98_V 143_G 1.567 1.00
214_V 218_W 1.548 1.00
88_H 209_I 1.541 1.00
88_H 204_A 1.534 1.00
61_F 241_G 1.526 1.00
76_K 258_E 1.483 1.00
83_M 129_A 1.476 1.00
300_M 303_D 1.464 1.00
159_F 358_G 1.463 1.00
225_I 247_Y 1.461 1.00
123_V 385_A 1.459 1.00
190_W 194_S 1.45 0.99
133_V 391_D 1.448 0.99
8_G 12_G 1.443 0.99
415_D 418_I 1.441 0.99
364_N 407_L 1.431 0.99
76_K 80_D 1.427 0.99
104_M 119_A 1.424 0.99
28_G 287_V 1.421 0.99
262_A 266_H 1.42 0.99
252_A 259_M 1.417 0.99
210_W 213_F 1.415 0.99
413_I 416_L 1.415 0.99
101_A 143_G 1.412 0.99
77_R 258_E 1.397 0.99
319_I 347_V 1.394 0.99
173_A 177_P 1.393 0.99
320_M 360_M 1.391 0.99
71_A 263_T 1.384 0.99
235_F 243_V 1.382 0.99
123_V 140_I 1.373 0.99
73_G 77_R 1.372 0.99
265_W 269_I 1.368 0.99
210_W 214_V 1.354 0.99
250_F 254_V 1.351 0.99
206_M 210_W 1.348 0.99
94_G 189_W 1.338 0.99
390_D 394_R 1.327 0.99
347_V 352_I 1.323 0.99
317_I 320_M 1.321 0.99
111_A 377_V 1.315 0.99
84_K 88_H 1.308 0.99
412_F 415_D 1.307 0.99
88_H 203_K 1.304 0.99
183_A 187_L 1.302 0.99
323_I 361_F 1.301 0.99
137_A 387_L 1.3 0.99
119_A 123_V 1.281 0.98
86_V 99_L 1.271 0.98
68_I 245_A 1.27 0.98
169_K 355_I 1.262 0.98
222_L 248_A 1.26 0.98
79_V 122_L 1.244 0.98
64_L 68_I 1.24 0.98
218_W 255_I 1.238 0.98
204_A 208_E 1.234 0.98
305_L 346_L 1.231 0.98
204_A 209_I 1.227 0.98
319_I 343_L 1.226 0.98
68_I 252_A 1.223 0.98
363_I 410_F 1.218 0.98
222_L 247_Y 1.215 0.98
94_G 126_M 1.215 0.98
64_L 271_A 1.213 0.98
344_M 348_K 1.211 0.98
156_F 174_G 1.211 0.98
351_G 354_P 1.209 0.98
299_M 303_D 1.208 0.97
68_I 249_L 1.201 0.97
163_S 340_T 1.193 0.97
72_G 252_A 1.19 0.97
25_L 287_V 1.183 0.97
125_M 128_S 1.183 0.97
303_D 307_P 1.179 0.97
61_F 242_A 1.173 0.97
313_R 320_M 1.167 0.97
135_R 189_W 1.165 0.97
137_A 385_A 1.164 0.97
404_Y 408_V 1.164 0.97
352_I 360_M 1.16 0.97
101_A 114_D 1.16 0.97
101_A 118_V 1.155 0.96
410_F 417_I 1.155 0.96
46_T 290_W 1.153 0.96
315_L 352_I 1.151 0.96
340_T 361_F 1.151 0.96
119_A 384_V 1.133 0.96
84_K 209_I 1.132 0.96
326_V 339_L 1.127 0.96
275_T 279_M 1.124 0.96
144_G 377_V 1.122 0.96
409_V 416_L 1.122 0.96
317_I 408_V 1.121 0.96
296_E 299_M 1.119 0.96
64_L 268_L 1.116 0.95
141_A 381_I 1.104 0.95
102_M 179_M 1.098 0.95
111_A 366_S 1.097 0.95
343_L 357_F 1.095 0.95
185_L 403_L 1.09 0.95
415_D 419_L 1.088 0.95
213_F 217_I 1.087 0.95
124_P 128_S 1.084 0.94
313_R 352_I 1.084 0.94
84_K 212_S 1.083 0.94
118_V 122_L 1.082 0.94
123_V 136_A 1.079 0.94
148_P 366_S 1.079 0.94
181_M 403_L 1.078 0.94
158_I 333_T 1.078 0.94
115_T 144_G 1.077 0.94
310_D 314_L 1.073 0.94
314_L 317_I 1.073 0.94
218_W 251_V 1.071 0.94
391_D 394_R 1.07 0.94
11_L 15_A 1.069 0.94
259_M 267_V 1.069 0.94
77_R 256_Y 1.059 0.94
207_Q 210_W 1.057 0.93
112_V 380_V 1.055 0.93
135_R 139_L 1.048 0.93
405_S 409_V 1.048 0.93
264_L 268_L 1.047 0.93
137_A 392_A 1.046 0.93
340_T 344_M 1.042 0.93
296_E 300_M 1.042 0.93
290_W 294_I 1.041 0.93
217_I 221_F 1.037 0.93
197_N 386_K 1.035 0.92
149_I 181_M 1.033 0.92
141_A 370_I 1.031 0.92
125_M 129_A 1.029 0.92
81_L 85_L 1.029 0.92
328_M 371_T 1.027 0.92
172_M 175_I 1.026 0.92
378_L 393_V 1.019 0.92
219_A 256_Y 1.017 0.92
302_S 306_Q 1.017 0.92
160_G 165_L 1.013 0.91
402_V 405_S 1.012 0.91
65_A 244_A 1.012 0.91
300_M 304_L 1.008 0.91
137_A 381_I 1.002 0.91
93_L 129_A 1.002 0.91
65_A 226_I 1.001 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.93181000.705Contact Map0.409
2m67A10.17419.10.978Contact Map0.481
2l2tA20.10354.20.981Contact Map0.483
2l9uA20.09183.70.982Contact Map0.316
2m20A20.14123.70.982Contact Map0.304
1iijA10.08243.40.982Contact Map0.701
2k1kA20.08942.70.983Contact Map0.254
2ks1B10.10352.40.983Contact Map0.182
2jwaA20.09651.90.984Contact Map0.727
1wazA10.09881.80.984Contact Map0.326
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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