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OPENSEQ.org
IAAA - Isoaspartyl peptidase
UniProt: P37595 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12407
Length: 321 (310)
Sequences: 1035
Seq/Len: 3.34
IAAA
Paralog alert: 0.16 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
57_V 194_A 4.724 1.00
54_T 108_L 4.635 1.00
42_M 47_E 4.19 1.00
107_V 194_A 3.947 1.00
191_L 226_A 3.612 1.00
281_D 285_N 3.506 1.00
190_N 222_N 3.343 1.00
72_A 82_L 3.338 1.00
100_V 109_A 3.212 1.00
58_R 108_L 3.077 1.00
147_S 151_E 3.06 1.00
62_E 105_N 2.977 1.00
51_D 111_R 2.72 1.00
123_I 208_V 2.598 1.00
36_V 298_A 2.586 1.00
98_A 123_I 2.534 1.00
245_I 277_L 2.404 1.00
111_R 115_E 2.313 1.00
54_T 111_R 2.16 1.00
75_T 81_E 2.129 1.00
257_A 261_E 2.125 1.00
150_Y 154_L 2.07 1.00
79_T 101_S 2.054 1.00
74_F 145_S 2.045 1.00
54_T 86_V 1.996 1.00
86_V 107_V 1.947 1.00
74_F 80_H 1.867 0.99
47_E 52_V 1.856 0.99
53_V 184_A 1.851 0.99
195_T 228_S 1.817 0.99
31_A 63_C 1.81 0.99
109_A 136_M 1.795 0.99
80_H 145_S 1.789 0.99
75_T 79_T 1.775 0.99
96_A 121_M 1.766 0.99
144_F 149_R 1.748 0.99
256_L 279_A 1.722 0.99
240_L 243_Y 1.692 0.99
88_D 91_T 1.649 0.98
248_L 254_L 1.648 0.98
185_L 191_L 1.643 0.98
77_D 129_N 1.639 0.98
34_A 63_C 1.639 0.98
112_L 116_Q 1.626 0.98
248_L 262_R 1.605 0.98
185_L 280_I 1.595 0.98
255_S 258_E 1.592 0.98
94_A 214_V 1.569 0.97
254_L 262_R 1.552 0.97
191_L 220_A 1.547 0.97
98_A 208_V 1.539 0.97
122_M 130_F 1.503 0.97
113_V 117_S 1.497 0.96
112_L 136_M 1.493 0.96
183_V 226_A 1.478 0.96
54_T 58_R 1.472 0.96
38_T 59_L 1.472 0.96
245_I 279_A 1.467 0.96
146_T 149_R 1.458 0.96
102_H 128_E 1.449 0.95
57_V 107_V 1.449 0.95
85_C 218_C 1.445 0.95
90_N 222_N 1.442 0.95
62_E 104_R 1.406 0.94
125_E 129_N 1.388 0.94
42_M 52_V 1.383 0.94
35_I 59_L 1.379 0.94
261_E 265_M 1.378 0.94
260_C 279_A 1.366 0.93
57_V 180_V 1.346 0.93
221_N 250_D 1.333 0.92
228_S 278_I 1.329 0.92
99_G 123_I 1.323 0.92
94_A 120_V 1.31 0.91
200_M 232_T 1.296 0.91
47_E 51_D 1.285 0.90
102_H 138_R 1.283 0.90
236_F 275_G 1.26 0.89
229_C 242_A 1.252 0.88
92_L 219_Y 1.251 0.88
52_V 56_A 1.249 0.88
144_F 156_A 1.248 0.88
26_L 30_E 1.246 0.88
98_A 121_M 1.244 0.88
6_I 36_V 1.242 0.88
130_F 134_R 1.229 0.87
56_A 182_A 1.224 0.87
85_C 214_V 1.219 0.87
53_V 194_A 1.217 0.87
35_I 52_V 1.217 0.87
120_V 234_E 1.201 0.86
254_L 257_A 1.196 0.85
41_K 45_A 1.188 0.85
244_D 247_A 1.18 0.84
254_L 258_E 1.177 0.84
244_D 251_Y 1.176 0.84
127_A 131_A 1.174 0.84
264_V 291_N 1.171 0.84
241_A 263_V 1.168 0.83
132_F 138_R 1.158 0.83
121_M 213_L 1.156 0.82
64_P 146_T 1.155 0.82
227_V 242_A 1.154 0.82
183_V 228_S 1.151 0.82
82_L 100_V 1.143 0.81
274_S 292_T 1.142 0.81
90_N 190_N 1.126 0.80
236_F 241_A 1.125 0.80
213_L 216_A 1.124 0.80
38_T 55_E 1.124 0.80
62_E 106_P 1.118 0.79
154_L 157_R 1.114 0.79
28_Y 65_L 1.11 0.79
225_V 246_A 1.099 0.78
227_V 279_A 1.096 0.78
74_F 150_Y 1.094 0.77
103_L 109_A 1.082 0.76
40_Q 44_E 1.082 0.76
81_E 101_S 1.078 0.76
89_G 220_A 1.076 0.76
16_S 20_M 1.074 0.76
50_L 115_E 1.071 0.75
49_A 186_D 1.066 0.75
145_S 150_Y 1.059 0.74
193_A 218_C 1.059 0.74
197_T 210_D 1.058 0.74
50_L 86_V 1.04 0.72
9_H 12_A 1.04 0.72
105_N 108_L 1.037 0.72
117_S 130_F 1.034 0.72
76_R 205_P 1.031 0.71
117_S 204_L 1.03 0.71
33_S 37_E 1.022 0.70
13_G 67_N 1.015 0.70
55_E 59_L 1.012 0.69
249_M 279_A 1.011 0.69
256_L 287_A 1.007 0.69
97_V 113_V 1.004 0.68
35_I 55_E 1.002 0.68
262_R 266_E 1.002 0.68
167_S 170_P 1 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c17A20.99691000.048Contact Map0.841
4gdvA20.95331000.1Contact Map0.87
2a8jA20.97821000.121Contact Map0.823
1p4kA20.88791000.205Contact Map0.825
1k2xA20.55141000.496Contact Map0.798
2gezA40.59191000.509Contact Map0.819
1k2xB20.44551000.583Contact Map0.866
2gezB40.41431000.609Contact Map0.845
1apyA20.47041000.61Contact Map0.633
1apyB20.42061000.637Contact Map0.876
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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