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OPENSEQ.org
YCAI - Uncharacterized protein YcaI
UniProt: P37443 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12375
Length: 754 (740)
Sequences: 948
Seq/Len: 1.28
YCAI
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
661_V 683_A 5.338 1.00
638_I 642_A 3.831 1.00
656_A 678_V 3.705 1.00
503_M 684_L 3.67 1.00
522_L 550_P 3.376 1.00
618_N 639_E 3.294 1.00
147_F 152_Y 3.111 1.00
638_I 662_P 2.968 1.00
133_L 162_G 2.887 1.00
513_V 522_L 2.867 1.00
676_Q 707_Q 2.816 1.00
149_S 153_A 2.798 1.00
662_P 704_Y 2.792 1.00
143_N 719_Q 2.708 1.00
500_Q 515_A 2.671 1.00
144_D 719_Q 2.654 1.00
138_V 153_A 2.569 1.00
510_L 660_Q 2.507 1.00
504_L 513_V 2.452 1.00
553_V 566_L 2.448 1.00
682_V 712_I 2.41 0.99
687_A 713_D 2.382 0.99
515_A 546_H 2.303 0.99
674_L 678_V 2.258 0.99
624_K 631_S 2.189 0.99
675_I 709_Y 2.174 0.99
643_E 670_S 2.156 0.98
670_S 704_Y 2.142 0.98
685_A 711_W 2.142 0.98
522_L 569_I 2.116 0.98
687_A 715_P 2.11 0.98
516_R 599_Q 2.089 0.98
501_L 632_I 2.078 0.98
226_A 280_P 2.036 0.98
370_L 374_P 2.024 0.97
508_Q 691_N 2.008 0.97
596_W 603_F 1.985 0.97
502_Y 719_Q 1.971 0.97
523_Y 634_L 1.939 0.96
654_V 678_V 1.926 0.96
670_S 703_R 1.923 0.96
503_M 512_M 1.917 0.96
640_A 671_S 1.91 0.96
561_D 663_H 1.896 0.96
508_Q 688_S 1.859 0.95
278_Q 281_A 1.841 0.95
667_N 697_S 1.832 0.95
542_W 546_H 1.828 0.95
662_P 670_S 1.809 0.94
311_L 331_A 1.804 0.94
205_R 226_A 1.78 0.94
513_V 542_W 1.777 0.94
637_D 663_H 1.773 0.93
685_A 704_Y 1.771 0.93
590_C 621_C 1.765 0.93
557_H 663_H 1.761 0.93
624_K 656_A 1.76 0.93
513_V 550_P 1.757 0.93
654_V 674_L 1.739 0.93
277_M 285_M 1.721 0.92
557_H 562_H 1.713 0.92
643_E 703_R 1.707 0.92
114_M 133_L 1.69 0.91
663_H 666_S 1.684 0.91
639_E 642_A 1.683 0.91
549_E 576_L 1.679 0.91
520_A 550_P 1.675 0.91
562_H 663_H 1.672 0.91
683_A 704_Y 1.669 0.90
683_A 709_Y 1.666 0.90
712_I 720_T 1.649 0.90
552_G 577_W 1.648 0.90
561_D 637_D 1.647 0.90
661_V 704_Y 1.643 0.89
224_L 394_A 1.627 0.89
617_N 620_S 1.625 0.89
659_L 680_G 1.605 0.88
561_D 664_H 1.603 0.88
287_A 310_C 1.602 0.88
272_A 285_M 1.579 0.87
557_H 561_D 1.568 0.86
557_H 637_D 1.567 0.86
503_M 686_S 1.564 0.86
508_Q 695_L 1.558 0.86
328_W 379_I 1.541 0.85
657_T 681_K 1.537 0.85
562_H 637_D 1.536 0.85
533_D 568_S 1.512 0.83
336_A 368_I 1.511 0.83
503_M 660_Q 1.508 0.83
562_H 664_H 1.502 0.83
499_W 627_D 1.498 0.83
314_I 321_A 1.484 0.82
659_L 704_Y 1.484 0.82
603_F 625_V 1.476 0.81
527_L 534_S 1.474 0.81
499_W 724_F 1.462 0.81
561_D 617_N 1.46 0.80
205_R 284_T 1.458 0.80
637_D 664_H 1.447 0.80
272_A 281_A 1.445 0.79
668_T 700_V 1.442 0.79
557_H 664_H 1.434 0.79
507_G 637_D 1.431 0.79
622_V 638_I 1.427 0.78
618_N 641_P 1.421 0.78
508_Q 696_P 1.415 0.77
604_S 626_D 1.411 0.77
682_V 722_V 1.411 0.77
402_T 431_S 1.41 0.77
661_V 685_A 1.409 0.77
557_H 666_S 1.406 0.77
688_S 691_N 1.403 0.77
524_D 562_H 1.4 0.76
523_Y 556_S 1.4 0.76
643_E 669_S 1.399 0.76
513_V 520_A 1.399 0.76
525_T 566_L 1.398 0.76
562_H 696_P 1.398 0.76
556_S 621_C 1.395 0.76
232_I 268_A 1.377 0.75
620_S 636_G 1.376 0.75
604_S 624_K 1.371 0.74
216_M 436_F 1.37 0.74
617_N 663_H 1.358 0.73
508_Q 694_R 1.357 0.73
328_W 621_C 1.355 0.73
516_R 601_L 1.346 0.72
624_K 677_R 1.345 0.72
639_E 671_S 1.342 0.72
506_V 509_G 1.329 0.71
669_S 700_V 1.328 0.71
87_A 92_T 1.325 0.71
519_K 599_Q 1.316 0.70
508_Q 693_W 1.315 0.70
524_D 557_H 1.312 0.70
637_D 666_S 1.311 0.69
561_D 666_S 1.308 0.69
138_V 149_S 1.306 0.69
209_P 212_I 1.305 0.69
222_A 226_A 1.304 0.69
570_L 575_M 1.303 0.69
226_A 284_T 1.302 0.69
219_T 390_A 1.301 0.69
606_H 654_V 1.301 0.69
701_K 711_W 1.3 0.69
593_G 605_A 1.296 0.68
624_K 678_V 1.288 0.68
368_I 372_L 1.285 0.67
535_G 538_L 1.283 0.67
387_S 513_V 1.276 0.66
527_L 560_L 1.275 0.66
539_I 569_I 1.272 0.66
280_P 326_S 1.27 0.66
508_Q 663_H 1.267 0.66
337_L 364_L 1.265 0.65
521_I 554_I 1.264 0.65
557_H 696_P 1.261 0.65
140_G 146_G 1.257 0.65
519_K 551_E 1.248 0.64
597_Q 602_R 1.248 0.64
659_L 675_I 1.247 0.64
556_S 636_G 1.247 0.64
508_Q 562_H 1.247 0.64
675_I 703_R 1.246 0.64
524_D 663_H 1.245 0.64
658_L 722_V 1.239 0.63
365_Q 590_C 1.237 0.63
675_I 701_K 1.235 0.63
524_D 664_H 1.234 0.63
205_R 230_L 1.231 0.62
153_A 161_T 1.229 0.62
510_L 523_Y 1.228 0.62
562_H 666_S 1.225 0.62
524_D 561_D 1.22 0.61
230_L 233_A 1.214 0.61
637_D 665_G 1.214 0.61
514_I 625_V 1.209 0.60
637_D 696_P 1.209 0.60
273_W 277_M 1.209 0.60
504_L 535_G 1.208 0.60
8_V 12_S 1.208 0.60
624_K 654_V 1.205 0.60
506_V 664_H 1.203 0.60
16_P 20_L 1.195 0.59
265_I 289_A 1.194 0.59
595_A 604_S 1.193 0.59
502_Y 542_W 1.191 0.59
503_M 510_L 1.191 0.59
506_V 562_H 1.19 0.58
509_G 557_H 1.188 0.58
667_N 699_K 1.188 0.58
311_L 327_L 1.185 0.58
513_V 548_L 1.184 0.58
670_S 674_L 1.183 0.58
562_H 665_G 1.179 0.57
562_H 620_S 1.179 0.57
365_Q 368_I 1.177 0.57
631_S 656_A 1.176 0.57
147_F 227_I 1.175 0.57
521_I 623_V 1.174 0.57
643_E 675_I 1.174 0.57
199_G 208_V 1.173 0.57
534_S 538_L 1.169 0.56
663_H 696_P 1.164 0.56
502_Y 721_T 1.162 0.56
509_G 696_P 1.162 0.56
561_D 665_G 1.158 0.55
145_G 535_G 1.156 0.55
632_I 658_L 1.156 0.55
78_T 83_V 1.156 0.55
557_H 636_G 1.155 0.55
656_A 674_L 1.153 0.55
17_L 20_L 1.153 0.55
506_V 696_P 1.148 0.54
507_G 561_D 1.148 0.54
691_N 694_R 1.146 0.54
323_L 328_W 1.145 0.54
664_H 696_P 1.144 0.54
616_G 619_H 1.142 0.54
523_Y 660_Q 1.139 0.54
525_T 553_V 1.138 0.53
668_T 671_S 1.136 0.53
29_L 36_A 1.135 0.53
224_L 620_S 1.134 0.53
200_L 404_P 1.13 0.53
391_N 396_P 1.13 0.53
605_A 608_P 1.128 0.52
45_K 58_V 1.127 0.52
617_N 666_S 1.124 0.52
508_Q 557_H 1.124 0.52
655_Q 678_V 1.124 0.52
230_L 281_A 1.124 0.52
639_E 662_P 1.124 0.52
303_G 338_I 1.123 0.52
365_Q 369_T 1.121 0.52
365_Q 372_L 1.117 0.51
439_L 566_L 1.113 0.51
138_V 161_T 1.113 0.51
509_G 637_D 1.112 0.51
526_G 622_V 1.111 0.51
336_A 371_L 1.111 0.51
557_H 620_S 1.111 0.51
688_S 713_D 1.111 0.51
509_G 562_H 1.11 0.51
505_D 696_P 1.11 0.51
205_R 222_A 1.108 0.50
638_I 704_Y 1.107 0.50
665_G 696_P 1.106 0.50
524_D 665_G 1.103 0.50
617_N 664_H 1.098 0.49
508_Q 664_H 1.098 0.49
216_M 221_T 1.096 0.49
221_T 542_W 1.095 0.49
562_H 636_G 1.091 0.49
328_W 365_Q 1.089 0.49
557_H 665_G 1.089 0.49
225_M 398_V 1.086 0.48
302_S 525_T 1.085 0.48
691_N 695_L 1.085 0.48
671_S 703_R 1.084 0.48
741_R 744_H 1.079 0.48
524_D 637_D 1.079 0.48
688_S 715_P 1.078 0.47
506_V 561_D 1.078 0.47
235_A 239_A 1.076 0.47
508_Q 637_D 1.074 0.47
34_L 51_A 1.073 0.47
224_L 404_P 1.072 0.47
365_Q 621_C 1.071 0.47
504_L 539_I 1.07 0.47
502_Y 546_H 1.068 0.46
535_G 565_G 1.067 0.46
686_S 714_T 1.067 0.46
511_A 635_T 1.064 0.46
525_T 564_G 1.063 0.46
230_L 399_T 1.062 0.46
524_D 696_P 1.06 0.46
506_V 524_D 1.06 0.46
561_D 696_P 1.058 0.46
532_G 535_G 1.057 0.45
231_H 396_P 1.057 0.45
221_T 395_I 1.056 0.45
698_N 702_H 1.055 0.45
314_I 331_A 1.053 0.45
281_A 284_T 1.051 0.45
203_G 331_A 1.049 0.45
509_G 524_D 1.048 0.45
509_G 561_D 1.047 0.44
328_W 590_C 1.046 0.44
643_E 668_T 1.046 0.44
557_H 617_N 1.046 0.44
404_P 564_G 1.046 0.44
662_P 693_W 1.044 0.44
337_L 365_Q 1.041 0.44
522_L 553_V 1.041 0.44
670_S 675_I 1.039 0.44
541_P 669_S 1.035 0.43
224_L 395_I 1.035 0.43
307_W 311_L 1.035 0.43
13_G 23_L 1.033 0.43
559_H 562_H 1.029 0.43
508_Q 561_D 1.027 0.42
559_H 637_D 1.026 0.42
316_L 720_T 1.026 0.42
56_F 60_G 1.026 0.42
508_Q 666_S 1.025 0.42
509_G 664_H 1.025 0.42
605_A 623_V 1.024 0.42
506_V 557_H 1.023 0.42
370_L 375_V 1.023 0.42
233_A 715_P 1.019 0.42
506_V 663_H 1.019 0.42
535_G 568_S 1.018 0.42
199_G 603_F 1.017 0.42
620_S 637_D 1.017 0.42
659_L 678_V 1.016 0.41
328_W 556_S 1.016 0.41
500_Q 721_T 1.016 0.41
155_A 324_S 1.015 0.41
561_D 620_S 1.014 0.41
31_F 37_C 1.014 0.41
507_G 562_H 1.012 0.41
525_T 565_G 1.011 0.41
554_I 605_A 1.011 0.41
387_S 405_L 1.011 0.41
500_Q 723_N 1.01 0.41
660_Q 685_A 1.01 0.41
666_S 696_P 1.01 0.41
501_L 634_L 1.009 0.41
540_I 568_S 1.009 0.41
272_A 277_M 1.008 0.41
391_N 395_I 1.008 0.41
510_L 686_S 1.006 0.40
635_T 660_Q 1.004 0.40
506_V 637_D 1.003 0.40
499_W 514_I 1.001 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2bibA10.34351000.756Contact Map0.533
3bv6A60.38731000.829Contact Map0.35
2wylA60.37141000.833Contact Map0.356
3adrA20.26661000.836Contact Map0.281
2gcuA40.28251000.842Contact Map0.283
2qedA10.28911000.854Contact Map0.374
1xm8A20.29581000.86Contact Map0.392
1qh5A20.285199.90.862Contact Map0.408
2p18A10.310399.90.871Contact Map0.372
1k07A20.279899.90.877Contact Map0.356
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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