May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YECE - UPF0759 protein YecE
UniProt: P37348 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12379
Length: 272 (261)
Sequences: 1129
Seq/Len: 4.33
YECE
Paralog alert: 0.12 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
31_C 232_F 4.513 1.00
214_Q 251_D 3.344 1.00
210_R 247_T 2.648 1.00
51_R 92_A 2.559 1.00
54_T 94_R 2.383 1.00
64_F 100_L 2.334 1.00
54_T 60_F 2.308 1.00
42_P 47_V 2.288 1.00
131_V 146_L 2.275 1.00
213_F 251_D 2.088 1.00
11_H 14_W 2.082 1.00
69_S 100_L 2.067 1.00
102_L 114_L 2.058 1.00
115_W 153_R 2.057 1.00
118_L 155_V 2.023 1.00
57_D 93_P 1.928 1.00
235_T 241_A 1.905 1.00
44_P 48_L 1.877 1.00
61_C 97_Q 1.867 1.00
30_N 249_W 1.841 1.00
119_D 153_R 1.84 1.00
16_R 24_E 1.786 1.00
195_N 230_Y 1.755 0.99
25_Y 32_V 1.739 0.99
247_T 250_E 1.695 0.99
28_H 246_H 1.66 0.99
3_Y 30_N 1.633 0.99
42_P 87_R 1.602 0.99
22_L 54_T 1.574 0.99
201_I 235_T 1.572 0.99
82_T 86_T 1.569 0.99
220_L 231_L 1.569 0.99
55_T 94_R 1.568 0.99
148_R 152_Q 1.567 0.99
59_R 230_Y 1.527 0.98
198_I 216_W 1.526 0.98
121_L 127_Y 1.518 0.98
97_Q 230_Y 1.508 0.98
129_V 150_L 1.5 0.98
100_L 127_Y 1.5 0.98
55_T 58_F 1.498 0.98
196_P 229_P 1.492 0.98
18_G 24_E 1.479 0.98
7_P 232_F 1.462 0.97
49_R 53_Q 1.447 0.97
128_G 158_V 1.444 0.97
6_L 25_Y 1.436 0.97
115_W 152_Q 1.404 0.97
85_L 98_Y 1.393 0.96
96_G 230_Y 1.389 0.96
37_T 47_V 1.386 0.96
61_C 232_F 1.376 0.96
214_Q 250_E 1.342 0.95
217_L 248_L 1.337 0.95
79_D 83_E 1.334 0.95
51_R 54_T 1.333 0.95
201_I 234_H 1.317 0.95
11_H 236_P 1.311 0.94
34_G 46_V 1.308 0.94
108_P 135_Q 1.295 0.94
9_W 50_W 1.29 0.94
74_L 102_L 1.283 0.94
220_L 248_L 1.266 0.93
156_N 195_N 1.253 0.92
108_P 146_L 1.251 0.92
112_P 116_H 1.247 0.92
2_I 252_L 1.24 0.92
68_I 81_V 1.236 0.92
23_E 27_R 1.224 0.91
200_F 231_L 1.221 0.91
64_F 98_Y 1.219 0.91
63_K 101_Q 1.205 0.90
136_F 146_L 1.199 0.90
149_G 153_R 1.195 0.90
115_W 119_D 1.195 0.90
217_L 252_L 1.193 0.90
131_V 136_F 1.19 0.90
268_Q 271_L 1.18 0.89
35_N 70_H 1.166 0.88
201_I 244_L 1.163 0.88
51_R 93_P 1.161 0.88
65_P 84_F 1.16 0.88
48_L 90_P 1.16 0.88
38_L 73_A 1.154 0.88
117_F 155_V 1.149 0.87
75_R 113_A 1.148 0.87
24_E 28_H 1.141 0.87
9_W 22_L 1.138 0.87
217_L 221_A 1.125 0.86
48_L 52_E 1.122 0.86
26_A 54_T 1.12 0.86
78_D 120_S 1.111 0.85
56_D 218_Q 1.111 0.85
86_T 89_S 1.106 0.85
7_P 14_W 1.096 0.84
244_L 247_T 1.093 0.84
43_K 46_V 1.085 0.83
156_N 193_A 1.082 0.83
49_R 52_E 1.077 0.82
221_A 252_L 1.075 0.82
163_R 203_S 1.07 0.82
67_T 80_L 1.065 0.81
35_N 232_F 1.05 0.80
196_P 226_T 1.045 0.80
38_L 102_L 1.034 0.79
118_L 129_V 1.033 0.79
38_L 68_I 1.027 0.78
26_A 60_F 1.018 0.77
86_T 211_E 1.017 0.77
47_V 87_R 1.017 0.77
7_P 11_H 1.013 0.77
201_I 236_P 1.012 0.77
64_F 121_L 1.011 0.76
44_P 86_T 1.01 0.76
34_G 60_F 1.009 0.76
72_A 80_L 1.007 0.76
47_V 91_L 1.006 0.76
83_E 86_T 1.005 0.76
202_G 235_T 1.001 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vpyA10.91541000.167Contact Map0.609
1vpqA10.85661000.174Contact Map0.662
1k77A10.838278.80.947Contact Map0.4
4hnoA10.867676.30.948Contact Map0.461
2hk0A40.8493740.949Contact Map0.552
1qtwA10.882469.90.951Contact Map0.412
3aamA10.8676670.952Contact Map0.413
3ngfA20.841964.20.953Contact Map0.276
3kwsA20.838262.30.953Contact Map0.454
2qw5A20.900759.50.954Contact Map0.417
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0144 seconds.