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OPENSEQ.org
PURU - Formyltetrahydrofolate deformylase
UniProt: P37051 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11819
Length: 280 (275)
Sequences: 1002
Seq/Len: 3.64
PURU
Paralog alert: 0.11 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
219_Y 265_V 4.76 1.00
125_R 129_E 4.759 1.00
151_K 154_D 4.219 1.00
122_D 125_R 3.979 1.00
117_V 128_V 3.911 1.00
138_V 148_H 3.496 1.00
231_M 236_H 3.445 1.00
87_I 112_V 3.073 1.00
200_R 203_H 3.035 1.00
88_V 116_A 2.657 1.00
141_E 144_T 2.633 1.00
27_C 32_L 2.62 1.00
26_I 67_L 2.488 1.00
233_D 257_V 2.401 1.00
157_D 180_R 2.323 1.00
85_R 268_Q 2.192 1.00
241_Y 249_A 2.175 1.00
86_R 113_E 2.156 1.00
175_P 222_D 2.098 1.00
112_V 266_L 2.036 1.00
115_A 161_P 2.011 1.00
101_L 262_L 1.981 1.00
149_D 174_T 1.934 1.00
60_D 64_L 1.884 1.00
176_E 179_A 1.865 1.00
223_N 226_E 1.844 0.99
88_V 161_P 1.8 0.99
100_D 104_K 1.795 0.99
163_Y 262_L 1.789 0.99
91_V 119_G 1.716 0.99
181_F 185_I 1.663 0.99
15_D 33_N 1.652 0.99
144_T 147_E 1.642 0.99
86_R 160_Q 1.639 0.99
153_A 180_R 1.607 0.98
36_Q 53_E 1.605 0.98
26_I 66_D 1.568 0.98
116_A 159_Y 1.551 0.98
118_I 152_M 1.546 0.98
30_H 66_D 1.535 0.98
22_R 73_E 1.535 0.98
183_N 272_V 1.465 0.96
217_A 261_A 1.463 0.96
90_L 152_M 1.449 0.96
80_N 268_Q 1.445 0.96
95_A 124_L 1.433 0.96
175_P 179_A 1.42 0.96
182_P 185_I 1.417 0.95
140_H 148_H 1.396 0.95
122_D 129_E 1.38 0.95
15_D 41_V 1.376 0.94
145_R 174_T 1.374 0.94
67_L 77_R 1.367 0.94
178_V 185_I 1.356 0.94
154_D 158_A 1.344 0.94
25_N 29_K 1.34 0.93
12_I 76_V 1.34 0.93
59_N 62_T 1.335 0.93
93_K 123_T 1.335 0.93
186_I 230_I 1.324 0.93
23_I 75_S 1.322 0.93
197_I 226_E 1.305 0.92
23_I 50_M 1.294 0.92
263_Y 267_A 1.287 0.91
27_C 54_L 1.27 0.91
67_L 79_L 1.263 0.90
126_S 129_E 1.256 0.90
146_N 176_E 1.255 0.90
90_L 164_V 1.253 0.90
235_I 253_V 1.251 0.90
238_D 241_Y 1.246 0.90
203_H 247_M 1.24 0.89
156_I 164_V 1.237 0.89
19_L 39_E 1.235 0.89
122_D 137_L 1.227 0.89
152_M 177_F 1.223 0.88
21_A 25_N 1.217 0.88
166_L 220_V 1.216 0.88
273_Y 278_I 1.208 0.88
61_S 65_A 1.204 0.87
105_A 114_I 1.189 0.87
9_L 79_L 1.184 0.86
10_R 78_E 1.184 0.86
243_A 246_M 1.181 0.86
146_N 150_Q 1.178 0.86
145_R 171_R 1.177 0.86
88_V 118_I 1.176 0.86
117_V 129_E 1.172 0.85
65_A 68_D 1.158 0.84
39_E 52_T 1.155 0.84
253_V 257_V 1.152 0.84
104_K 259_S 1.13 0.82
265_V 270_V 1.125 0.82
150_Q 154_D 1.109 0.81
8_V 268_Q 1.108 0.81
140_H 144_T 1.103 0.80
86_R 115_A 1.102 0.80
104_K 109_G 1.102 0.80
87_I 163_Y 1.093 0.79
60_D 81_P 1.087 0.79
100_D 259_S 1.085 0.79
203_H 207_E 1.084 0.79
174_T 261_A 1.083 0.79
61_S 64_L 1.08 0.78
149_D 261_A 1.063 0.77
109_G 251_R 1.062 0.77
116_A 161_P 1.057 0.76
164_V 278_I 1.056 0.76
90_L 118_I 1.056 0.76
19_L 73_E 1.054 0.76
219_Y 233_D 1.042 0.75
99_G 103_M 1.027 0.73
204_Q 226_E 1.024 0.73
42_D 273_Y 1.019 0.72
126_S 132_D 1.019 0.72
136_E 159_Y 1.017 0.72
95_A 103_M 1.005 0.71
150_Q 176_E 1.002 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nrbA411000.302Contact Map0.698
3louA411000.303Contact Map0.772
3obiA40.99641000.311Contact Map0.734
3n0vA411000.318Contact Map0.783
3o1lA211000.322Contact Map0.78
1jkxA40.71000.609Contact Map0.688
3tqrA10.71431000.61Contact Map0.662
2ywrA10.70361000.611Contact Map0.701
3aufA10.7751000.614Contact Map0.656
4ds3A10.7251000.62Contact Map0.69
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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