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OPENSEQ.org
YAEI - Phosphodiesterase YaeI
UniProt: P37049 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12337
Length: 270 (260)
Sequences: 1676
Seq/Len: 6.45
YAEI
Paralog alert: 0.35 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
53_F 86_G 5.686 1.00
84_L 187_L 3.801 1.00
83_I 108_L 3.719 1.00
49_F 112_A 3.686 1.00
50_K 268_E 3.445 1.00
41_F 183_P 3.237 1.00
52_L 266_M 2.746 1.00
234_A 248_R 2.604 1.00
52_L 80_P 2.562 1.00
78_Q 266_M 2.469 1.00
38_R 268_E 2.405 1.00
115_F 161_L 2.327 1.00
245_Y 265_T 2.241 1.00
37_H 245_Y 2.221 1.00
47_A 270_V 2.211 1.00
114_T 142_I 2.19 1.00
38_R 270_V 2.084 1.00
143_T 150_T 2.067 1.00
85_L 89_Y 2.023 1.00
52_L 75_G 2.008 1.00
146_F 165_G 1.982 1.00
75_G 108_L 1.96 1.00
54_L 75_G 1.957 1.00
205_M 242_R 1.914 1.00
72_I 76_I 1.89 1.00
116_A 144_V 1.872 1.00
236_L 243_H 1.852 1.00
69_S 107_P 1.842 1.00
237_N 246_T 1.816 1.00
55_A 247_T 1.79 1.00
69_S 73_A 1.764 1.00
43_K 203_D 1.764 1.00
194_K 239_F 1.722 1.00
53_F 247_T 1.696 1.00
238_A 243_H 1.687 1.00
173_K 176_P 1.683 1.00
115_F 150_T 1.646 1.00
134_G 146_F 1.644 1.00
36_R 268_E 1.636 1.00
50_K 266_M 1.633 1.00
51_I 82_L 1.622 1.00
59_Y 68_I 1.618 1.00
238_A 241_E 1.606 1.00
85_L 142_I 1.586 1.00
160_E 182_L 1.584 1.00
74_L 78_Q 1.564 0.99
162_V 184_R 1.554 0.99
232_Y 237_N 1.52 0.99
153_A 156_N 1.495 0.99
245_Y 267_L 1.477 0.99
151_V 160_E 1.473 0.99
37_H 265_T 1.446 0.99
188_A 207_C 1.439 0.99
153_A 158_Q 1.41 0.99
136_T 139_S 1.406 0.99
53_F 206_L 1.404 0.99
83_I 110_E 1.399 0.98
52_L 78_Q 1.396 0.98
152_I 161_L 1.382 0.98
160_E 184_R 1.38 0.98
36_R 266_M 1.358 0.98
151_V 158_Q 1.348 0.98
162_V 202_W 1.322 0.98
166_D 190_N 1.317 0.98
143_T 148_Q 1.31 0.97
161_L 185_L 1.308 0.97
35_I 248_R 1.307 0.97
86_G 247_T 1.3 0.97
194_K 244_I 1.295 0.97
51_I 84_L 1.283 0.97
194_K 242_R 1.281 0.97
82_L 115_F 1.273 0.97
110_E 113_P 1.272 0.97
36_R 78_Q 1.268 0.97
46_A 49_F 1.262 0.97
122_D 133_I 1.261 0.97
149_A 160_E 1.25 0.96
55_A 86_G 1.24 0.96
118_F 134_G 1.239 0.96
174_P 186_V 1.239 0.96
76_I 111_C 1.225 0.96
218_P 248_R 1.22 0.96
247_T 265_T 1.217 0.96
40_A 270_V 1.206 0.95
206_L 267_L 1.202 0.95
46_A 159_F 1.201 0.95
164_T 188_A 1.193 0.95
186_V 202_W 1.188 0.95
89_Y 116_A 1.175 0.94
31_W 261_R 1.156 0.94
110_E 114_T 1.154 0.94
151_V 182_L 1.145 0.93
116_A 142_I 1.126 0.92
69_S 104_V 1.121 0.92
48_P 269_L 1.118 0.92
131_H 135_E 1.104 0.91
46_A 154_T 1.1 0.91
118_F 122_D 1.096 0.91
135_E 139_S 1.091 0.91
54_L 57_L 1.086 0.91
149_A 178_S 1.086 0.91
86_G 187_L 1.08 0.90
150_T 161_L 1.078 0.90
147_N 164_T 1.07 0.90
84_L 161_L 1.069 0.90
76_I 110_E 1.068 0.90
86_G 206_L 1.066 0.89
159_F 183_P 1.064 0.89
54_L 85_L 1.062 0.89
186_V 197_M 1.058 0.89
251_G 257_R 1.058 0.89
11_T 14_T 1.057 0.89
105_L 113_P 1.053 0.89
194_K 205_M 1.049 0.88
84_L 206_L 1.046 0.88
86_G 117_C 1.044 0.88
33_E 261_R 1.034 0.87
35_I 265_T 1.033 0.87
160_E 178_S 1.027 0.87
248_R 265_T 1.026 0.87
184_R 202_W 1.021 0.87
49_F 154_T 1.02 0.86
74_L 264_V 1.019 0.86
135_E 138_K 1.019 0.86
34_L 264_V 1.018 0.86
179_E 182_L 1.018 0.86
116_A 122_D 1.015 0.86
76_I 109_A 1.005 0.85
45_N 48_P 1.003 0.85
134_G 138_K 1.002 0.85
118_F 133_I 1.002 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rl5A10.859399.90.654Contact Map0.536
3t1iA40.922299.90.664Contact Map0.546
4fbkA20.974199.90.665Contact Map0.539
4fbwA20.859399.90.668Contact Map0.544
1ii7A20.899.90.687Contact Map0.611
3d03A60.729699.90.689Contact Map0.689
2z1aA10.903799.90.692Contact Map0.599
2q8uA20.870499.90.696Contact Map0.629
3ib7A10.877899.90.705Contact Map0.642
3thoB10.814899.90.707Contact Map0.646
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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