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OPENSEQ.org
NAPH - Ferredoxin-type protein NapH
UniProt: P33934 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12062
Length: 287 (261)
Sequences: 1006
Seq/Len: 3.85
NAPH
Paralog alert: 0.41 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
125_F 141_L 3.025 1.00
196_W 200_I 2.921 1.00
133_I 137_I 2.675 1.00
126_D 138_R 2.166 1.00
121_L 148_G 2.159 1.00
182_L 186_L 2.083 1.00
139_Y 185_F 2.08 1.00
99_A 103_L 2.023 1.00
34_F 38_M 1.995 1.00
30_L 34_F 1.927 1.00
104_F 108_V 1.914 1.00
121_L 141_L 1.877 1.00
23_R 26_V 1.825 1.00
27_L 31_C 1.818 1.00
195_G 199_H 1.734 0.99
125_F 137_I 1.699 0.99
158_E 163_V 1.606 0.98
231_D 269_V 1.605 0.98
137_I 141_L 1.573 0.98
138_R 259_D 1.561 0.98
227_N 272_E 1.558 0.98
204_G 211_G 1.545 0.98
61_D 65_L 1.537 0.98
216_I 219_A 1.516 0.98
152_T 184_L 1.514 0.98
158_E 161_N 1.504 0.97
37_G 41_S 1.503 0.97
106_S 261_M 1.493 0.97
28_R 116_D 1.464 0.97
187_F 191_V 1.459 0.97
120_W 124_R 1.456 0.97
225_K 274_V 1.453 0.97
231_D 235_V 1.432 0.96
179_L 216_I 1.415 0.96
93_T 206_L 1.373 0.95
40_L 151_L 1.366 0.95
130_S 217_T 1.365 0.95
146_L 181_I 1.353 0.94
104_F 209_V 1.34 0.94
91_I 95_L 1.328 0.94
235_V 269_V 1.321 0.93
142_L 205_A 1.319 0.93
183_A 186_L 1.319 0.93
29_R 32_Q 1.312 0.93
134_P 137_I 1.311 0.93
213_K 218_V 1.3 0.93
37_G 114_I 1.295 0.93
169_S 173_G 1.293 0.92
89_A 93_T 1.292 0.92
60_F 63_V 1.289 0.92
183_A 187_F 1.288 0.92
214_G 218_V 1.272 0.92
122_R 142_L 1.261 0.91
45_F 174_F 1.25 0.91
26_V 30_L 1.246 0.91
61_D 64_P 1.244 0.90
133_I 136_H 1.238 0.90
230_M 234_H 1.233 0.90
177_G 181_I 1.226 0.90
179_L 183_A 1.219 0.89
46_G 162_P 1.217 0.89
98_L 214_G 1.214 0.89
54_Y 57_S 1.213 0.89
30_L 147_V 1.211 0.89
93_T 210_L 1.201 0.88
36_L 114_I 1.195 0.88
42_G 58_L 1.193 0.88
122_R 135_R 1.184 0.87
106_S 269_V 1.183 0.87
90_V 190_L 1.178 0.87
23_R 136_H 1.172 0.87
158_E 167_G 1.163 0.86
240_H 259_D 1.159 0.86
110_P 259_D 1.156 0.86
118_A 149_S 1.152 0.85
114_I 152_T 1.147 0.85
113_P 150_A 1.142 0.85
107_W 191_V 1.133 0.84
237_P 265_R 1.129 0.84
69_L 73_Q 1.124 0.83
146_L 173_G 1.122 0.83
165_L 169_S 1.119 0.83
27_L 103_L 1.118 0.83
27_L 30_L 1.116 0.83
32_Q 36_L 1.115 0.83
84_V 87_T 1.107 0.82
106_S 111_L 1.106 0.82
140_V 171_V 1.098 0.81
22_H 215_V 1.089 0.81
195_G 198_G 1.079 0.80
154_T 170_L 1.079 0.80
99_A 179_L 1.078 0.80
74_S 78_G 1.076 0.79
135_R 182_L 1.074 0.79
203_V 242_L 1.069 0.79
31_C 107_W 1.067 0.79
172_M 175_G 1.063 0.78
64_P 67_D 1.061 0.78
108_V 272_E 1.056 0.78
70_M 157_W 1.056 0.78
179_L 214_G 1.053 0.77
168_R 171_V 1.053 0.77
23_R 216_I 1.046 0.77
22_H 214_G 1.045 0.77
267_V 275_F 1.044 0.77
107_W 271_S 1.044 0.77
198_G 238_E 1.043 0.76
42_G 45_F 1.043 0.76
25_L 33_F 1.039 0.76
32_Q 116_D 1.039 0.76
29_R 121_L 1.037 0.76
23_R 147_V 1.036 0.76
178_A 222_D 1.036 0.76
216_I 223_R 1.033 0.75
211_G 264_G 1.032 0.75
179_L 223_R 1.03 0.75
99_A 170_L 1.03 0.75
63_V 70_M 1.03 0.75
48_W 52_G 1.027 0.75
58_L 76_A 1.021 0.74
174_F 178_A 1.021 0.74
56_S 76_A 1.019 0.74
69_L 172_M 1.012 0.73
67_D 70_M 1.008 0.73
154_T 169_S 1 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1hfeL20.32498.90.851Contact Map0.809
3gyxB60.236998.80.857Contact Map0.766
1jnrB20.240498.80.857Contact Map0.766
7fd1A10.22398.80.858Contact Map0.533
1iqzA10.243998.80.858Contact Map0.328
1jb0C10.243998.80.861Contact Map0.689
1dwlA10.202198.70.862Contact Map0.202
2fdnA10.191698.70.864Contact Map0.687
2v2kA20.22398.70.864Contact Map0.583
2fgoA10.22398.70.864Contact Map0.781
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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