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OPENSEQ.org
FEOB - Ferrous iron transport protein B
UniProt: P33650 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12102
Length: 773 (714)
Sequences: 1383
Seq/Len: 1.94
FEOB
Paralog alert: 0.10 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
457_S 665_Y 4.86 1.00
662_A 715_A 4.436 1.00
117_V 143_C 3.848 1.00
42_E 53_T 3.72 1.00
126_E 154_R 3.464 1.00
669_I 711_F 3.382 1.00
182_L 202_R 3.351 1.00
308_P 311_D 3.187 1.00
91_N 105_T 3.162 1.00
274_V 278_V 3.061 1.00
90_I 163_I 3.046 1.00
666_S 708_A 2.928 1.00
561_I 709_T 2.771 1.00
124_I 493_H 2.762 1.00
280_N 283_L 2.742 1.00
304_G 308_P 2.691 1.00
140_R 258_V 2.579 1.00
400_G 407_S 2.565 1.00
509_K 513_L 2.443 1.00
669_I 707_L 2.432 1.00
429_F 703_I 2.385 1.00
136_A 139_A 2.354 1.00
358_G 508_L 2.345 1.00
424_I 688_S 2.27 1.00
558_F 571_T 2.226 1.00
311_D 315_V 2.218 1.00
694_G 698_L 2.218 1.00
570_A 667_Y 2.208 1.00
96_S 124_I 2.197 1.00
461_L 669_I 2.158 0.99
133_E 136_A 2.134 0.99
431_S 439_F 2.103 0.99
443_A 455_V 2.045 0.99
93_V 117_V 2.031 0.99
134_I 147_P 2.021 0.99
337_I 341_Q 2.02 0.99
408_V 684_I 2.012 0.99
116_I 163_I 2.008 0.99
252_I 256_C 1.994 0.99
95_A 119_L 1.961 0.99
465_M 673_L 1.934 0.99
28_Q 43_G 1.913 0.98
119_L 134_I 1.907 0.98
684_I 696_S 1.9 0.98
713_Q 716_S 1.892 0.98
662_A 666_S 1.882 0.98
670_F 704_A 1.852 0.98
136_A 140_R 1.849 0.98
412_R 687_E 1.84 0.98
681_M 693_M 1.831 0.98
81_I 113_I 1.829 0.98
125_A 132_I 1.809 0.97
710_L 714_V 1.807 0.97
162_A 165_R 1.773 0.97
738_V 742_L 1.767 0.97
437_A 441_V 1.763 0.97
298_L 363_F 1.758 0.97
19_L 148_L 1.752 0.97
382_R 386_A 1.749 0.97
681_M 697_I 1.702 0.96
358_G 504_T 1.699 0.96
207_Q 212_D 1.698 0.96
20_F 24_T 1.695 0.96
126_E 131_R 1.684 0.96
118_A 147_P 1.675 0.95
711_F 715_A 1.668 0.95
465_M 703_I 1.661 0.95
20_F 43_G 1.648 0.95
387_L 467_V 1.639 0.95
24_T 28_Q 1.621 0.94
6_I 163_I 1.613 0.94
404_N 680_V 1.607 0.94
135_D 139_A 1.606 0.94
362_L 366_F 1.598 0.94
724_S 728_I 1.593 0.94
675_V 701_L 1.592 0.94
457_S 461_L 1.59 0.94
290_F 294_L 1.585 0.93
125_A 130_I 1.585 0.93
48_T 161_L 1.575 0.93
126_E 147_P 1.563 0.93
555_T 571_T 1.558 0.93
304_G 307_Q 1.549 0.92
352_P 356_Q 1.547 0.92
20_F 28_Q 1.544 0.92
665_Y 711_F 1.534 0.92
122_L 148_L 1.533 0.92
392_K 415_D 1.531 0.92
24_T 43_G 1.513 0.91
340_A 344_G 1.511 0.91
338_F 343_L 1.506 0.91
461_L 665_Y 1.506 0.91
417_P 421_L 1.501 0.91
183_N 187_S 1.494 0.90
429_F 465_M 1.494 0.90
723_Y 727_C 1.492 0.90
570_A 658_F 1.491 0.90
307_Q 352_P 1.491 0.90
138_S 144_P 1.474 0.90
122_L 125_A 1.461 0.89
429_F 699_W 1.46 0.89
135_D 138_S 1.46 0.89
574_L 674_Y 1.455 0.89
421_L 688_S 1.453 0.89
660_S 663_A 1.443 0.88
553_V 556_P 1.441 0.88
304_G 311_D 1.44 0.88
270_F 274_V 1.429 0.88
393_S 423_T 1.42 0.87
90_I 159_L 1.414 0.87
108_L 115_C 1.395 0.86
106_L 255_I 1.381 0.85
425_M 695_F 1.379 0.85
728_I 731_V 1.379 0.85
410_G 413_T 1.377 0.85
105_T 108_L 1.369 0.84
23_L 28_Q 1.364 0.84
581_K 676_P 1.359 0.84
726_V 730_A 1.346 0.83
306_L 309_L 1.342 0.83
122_L 147_P 1.342 0.83
354_V 358_G 1.338 0.83
93_V 105_T 1.334 0.82
311_D 352_P 1.332 0.82
402_G 676_P 1.323 0.82
727_C 730_A 1.323 0.82
339_L 343_L 1.321 0.81
298_L 359_M 1.316 0.81
136_A 258_V 1.315 0.81
431_S 462_G 1.313 0.81
404_N 427_A 1.311 0.81
523_S 586_G 1.303 0.80
442_F 668_L 1.297 0.80
376_A 394_F 1.295 0.80
28_Q 41_K 1.295 0.80
666_S 712_Y 1.289 0.79
471_L 475_Y 1.286 0.79
461_L 464_V 1.284 0.79
576_T 587_T 1.283 0.79
577_G 584_V 1.282 0.79
9_I 108_L 1.278 0.78
469_T 473_L 1.277 0.78
498_K 502_I 1.272 0.78
66_I 73_D 1.267 0.78
438_I 584_V 1.266 0.77
560_P 705_Y 1.263 0.77
668_L 672_L 1.262 0.77
185_A 206_L 1.261 0.77
31_G 392_K 1.26 0.77
22_Q 153_G 1.256 0.77
119_L 147_P 1.254 0.77
78_C 212_D 1.247 0.76
401_F 463_I 1.246 0.76
517_K 521_I 1.243 0.76
685_A 690_R 1.241 0.75
696_S 700_G 1.241 0.75
120_N 150_S 1.238 0.75
336_T 340_A 1.237 0.75
106_L 251_C 1.236 0.75
184_E 229_A 1.232 0.75
458_L 668_L 1.227 0.74
160_K 163_I 1.227 0.74
188_L 226_L 1.227 0.74
67_S 71_S 1.226 0.74
457_S 662_A 1.225 0.74
497_V 501_I 1.222 0.74
22_Q 156_I 1.219 0.74
424_I 684_I 1.216 0.73
578_A 681_M 1.211 0.73
404_N 408_V 1.209 0.73
357_I 409_M 1.209 0.73
181_L 244_I 1.207 0.73
438_I 671_V 1.201 0.72
404_N 435_R 1.201 0.72
577_G 671_V 1.192 0.71
359_M 362_L 1.192 0.71
178_A 247_A 1.189 0.71
723_Y 728_I 1.187 0.71
303_G 307_Q 1.185 0.71
109_L 115_C 1.181 0.70
185_A 202_R 1.179 0.70
309_L 313_G 1.177 0.70
121_M 493_H 1.175 0.70
404_N 428_P 1.174 0.70
9_I 77_A 1.172 0.69
685_A 693_M 1.172 0.69
530_N 547_L 1.172 0.69
153_G 157_E 1.17 0.69
706_S 710_L 1.167 0.69
207_Q 210_E 1.164 0.69
7_G 86_A 1.161 0.68
431_S 466_A 1.161 0.68
185_A 188_L 1.16 0.68
365_S 504_T 1.158 0.68
550_V 553_V 1.157 0.68
73_D 77_A 1.156 0.68
17_T 41_K 1.156 0.68
11_N 101_N 1.154 0.68
581_K 674_Y 1.153 0.68
385_Q 390_P 1.147 0.67
110_E 248_R 1.146 0.67
91_N 108_L 1.146 0.67
365_S 503_Q 1.146 0.67
187_S 190_K 1.144 0.67
517_K 520_I 1.144 0.67
79_H 83_S 1.142 0.66
429_F 469_T 1.141 0.66
435_R 680_V 1.141 0.66
468_L 472_M 1.14 0.66
419_E 474_K 1.139 0.66
250_Q 254_A 1.138 0.66
709_T 713_Q 1.138 0.66
289_L 460_M 1.137 0.66
442_F 667_Y 1.136 0.66
17_T 30_V 1.133 0.66
293_Y 453_L 1.132 0.65
443_A 451_G 1.128 0.65
5_T 53_T 1.128 0.65
302_I 359_M 1.125 0.65
431_S 672_L 1.125 0.65
182_L 185_A 1.125 0.65
251_C 255_I 1.124 0.65
134_I 138_S 1.122 0.64
288_F 560_P 1.121 0.64
708_A 712_Y 1.12 0.64
269_R 272_T 1.118 0.64
351_L 512_V 1.118 0.64
161_L 165_R 1.117 0.64
118_A 159_L 1.114 0.64
401_F 430_M 1.113 0.64
188_L 192_M 1.113 0.64
296_F 401_F 1.113 0.64
46_S 51_Q 1.112 0.63
39_E 63_L 1.111 0.63
322_I 344_G 1.111 0.63
516_G 519_I 1.106 0.63
6_I 88_L 1.106 0.63
18_T 151_T 1.104 0.63
140_R 259_V 1.104 0.63
60_T 77_A 1.103 0.63
726_V 731_V 1.103 0.63
334_W 532_F 1.102 0.62
89_L 111_L 1.101 0.62
118_A 148_L 1.1 0.62
505_W 509_K 1.099 0.62
24_T 361_Y 1.098 0.62
308_P 312_V 1.097 0.62
34_A 145_V 1.095 0.62
725_L 728_I 1.095 0.62
231_A 235_N 1.095 0.62
31_G 413_T 1.091 0.61
224_Q 228_A 1.091 0.61
335_L 339_L 1.088 0.61
679_S 682_G 1.081 0.60
124_I 491_V 1.081 0.60
712_Y 716_S 1.081 0.60
202_R 205_G 1.08 0.60
227_D 231_A 1.08 0.60
369_D 499_S 1.078 0.60
425_M 696_S 1.077 0.60
136_A 259_V 1.076 0.60
11_N 17_T 1.075 0.60
97_N 485_F 1.074 0.59
695_F 699_W 1.074 0.59
433_G 680_V 1.073 0.59
19_L 118_A 1.072 0.59
536_G 539_V 1.066 0.59
92_V 148_L 1.064 0.58
577_G 581_K 1.064 0.58
306_L 310_F 1.063 0.58
293_Y 452_A 1.06 0.58
156_I 160_K 1.059 0.58
366_F 500_L 1.056 0.58
177_Y 182_L 1.053 0.57
360_M 437_A 1.052 0.57
279_L 379_V 1.052 0.57
64_T 73_D 1.051 0.57
462_G 466_A 1.05 0.57
666_S 669_I 1.047 0.57
428_P 466_A 1.047 0.57
378_F 487_M 1.046 0.56
439_F 466_A 1.044 0.56
297_L 301_N 1.043 0.56
294_L 702_N 1.042 0.56
118_A 155_G 1.041 0.56
702_N 706_S 1.038 0.56
555_T 559_K 1.038 0.56
663_A 712_Y 1.038 0.56
683_A 686_R 1.038 0.56
673_L 707_L 1.036 0.55
8_L 28_Q 1.034 0.55
688_S 693_M 1.034 0.55
72_L 417_P 1.034 0.55
728_I 732_I 1.034 0.55
322_I 326_G 1.032 0.55
447_F 664_A 1.031 0.55
88_L 116_I 1.03 0.55
684_I 688_S 1.03 0.55
504_T 508_L 1.029 0.55
469_T 699_W 1.029 0.55
179_Q 183_N 1.029 0.55
142_G 418_R 1.028 0.54
460_M 464_V 1.028 0.54
344_G 348_N 1.026 0.54
20_F 361_Y 1.026 0.54
438_I 442_F 1.025 0.54
285_L 289_L 1.024 0.54
514_R 517_K 1.023 0.54
408_V 680_V 1.022 0.54
325_I 339_L 1.02 0.54
727_C 731_V 1.019 0.53
732_I 736_I 1.019 0.53
138_S 162_A 1.018 0.53
723_Y 740_G 1.017 0.53
8_L 54_L 1.016 0.53
428_P 439_F 1.015 0.53
45_F 160_K 1.013 0.53
662_A 665_Y 1.013 0.53
155_G 158_A 1.013 0.53
376_A 384_M 1.013 0.53
278_V 287_I 1.012 0.53
723_Y 730_A 1.012 0.53
148_L 151_T 1.012 0.53
251_C 254_A 1.011 0.53
343_L 520_I 1.011 0.53
289_L 456_F 1.01 0.52
443_A 454_A 1.009 0.52
570_A 663_A 1.009 0.52
473_L 477_I 1.009 0.52
78_C 210_E 1.008 0.52
356_Q 359_M 1.007 0.52
459_Y 560_P 1.007 0.52
47_T 161_L 1.007 0.52
162_A 166_Y 1.006 0.52
6_I 90_I 1.006 0.52
98_L 260_S 1.003 0.52
45_F 52_V 1.002 0.52
430_M 466_A 1.001 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ibyA40.32341000.793Contact Map0.682
3k53A40.33511000.799Contact Map0.795
3b1vA10.34281000.8Contact Map0.727
3i8sA30.35321000.801Contact Map0.746
3a1sA20.3261000.801Contact Map0.769
2wjgA20.2381000.884Contact Map0.772
1mkyA10.31051000.886Contact Map0.573
2wjiA20.21351000.889Contact Map0.688
3geeA10.29751000.891Contact Map0.498
3w5jA20.26261000.891Contact Map0.746
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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