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OPENSEQ.org
PSUG - Pseudouridine-5'-phosphate glycosidase
UniProt: P33025 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12033
Length: 312 (302)
Sequences: 478
Seq/Len: 1.58
PSUG
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
129_A 300_A 3.857 1.00
172_G 203_F 3.428 1.00
187_G 205_V 3.382 1.00
237_I 288_S 3.288 1.00
53_E 57_K 3.009 1.00
192_A 202_P 2.903 1.00
12_Q 71_V 2.64 1.00
213_S 306_E 2.542 1.00
45_A 85_G 2.413 1.00
151_Q 181_F 2.391 1.00
140_A 173_L 2.365 1.00
72_M 119_I 2.309 1.00
121_A 157_N 2.304 0.99
36_S 110_A 2.281 0.99
258_E 276_R 2.256 0.99
50_E 294_F 2.192 0.99
21_L 27_V 2.188 0.99
245_E 249_N 2.179 0.99
49_I 78_K 2.154 0.99
49_I 81_I 2.111 0.99
73_K 80_E 2.059 0.99
95_S 114_A 2.056 0.99
140_A 144_F 2.047 0.99
117_M 156_T 2.046 0.99
187_G 190_T 1.996 0.98
58_Q 302_E 1.982 0.98
276_R 280_L 1.976 0.98
60_A 301_S 1.974 0.98
219_M 307_Y 1.96 0.98
34_I 293_V 1.938 0.98
191_K 208_R 1.918 0.98
94_V 102_V 1.892 0.97
275_A 279_E 1.852 0.97
69_G 83_L 1.851 0.97
94_V 109_G 1.846 0.97
276_R 279_E 1.828 0.96
192_A 200_T 1.786 0.96
18_Q 22_K 1.777 0.96
159_T 219_M 1.755 0.95
12_Q 73_K 1.753 0.95
39_M 51_V 1.751 0.95
215_I 233_V 1.744 0.95
233_V 303_I 1.736 0.95
54_T 294_F 1.713 0.94
117_M 158_V 1.698 0.94
144_F 173_L 1.662 0.93
171_L 193_L 1.661 0.93
254_Q 276_R 1.65 0.93
138_R 256_V 1.64 0.92
209_L 218_A 1.636 0.92
55_I 60_A 1.627 0.92
69_G 108_N 1.603 0.91
212_A 302_E 1.595 0.91
159_T 233_V 1.59 0.91
19_D 23_N 1.571 0.90
58_Q 298_I 1.533 0.89
29_A 120_A 1.512 0.88
16_E 56_R 1.5 0.87
165_A 171_L 1.497 0.87
222_K 229_G 1.496 0.87
219_M 231_L 1.493 0.87
32_S 66_A 1.487 0.87
209_L 215_I 1.481 0.86
188_Y 212_A 1.464 0.85
13_I 27_V 1.456 0.85
247_T 284_D 1.452 0.85
235_N 299_L 1.449 0.85
291_Q 294_F 1.44 0.84
77_S 80_E 1.435 0.84
122_L 225_S 1.418 0.83
251_A 281_T 1.414 0.83
165_A 193_L 1.413 0.83
262_Q 272_F 1.404 0.82
96_R 118_I 1.403 0.82
254_Q 280_L 1.379 0.80
257_A 261_A 1.358 0.79
83_L 108_N 1.341 0.78
96_R 152_E 1.34 0.78
161_V 233_V 1.333 0.77
281_T 285_S 1.331 0.77
157_N 222_K 1.315 0.76
190_T 205_V 1.31 0.75
258_E 262_Q 1.306 0.75
32_S 35_I 1.305 0.75
74_V 119_I 1.293 0.74
43_Q 46_Q 1.284 0.73
167_S 172_G 1.27 0.72
141_E 173_L 1.25 0.70
255_A 259_A 1.236 0.69
84_L 91_V 1.226 0.68
39_M 286_L 1.224 0.68
244_P 247_T 1.219 0.68
187_G 206_S 1.202 0.66
13_I 21_L 1.202 0.66
66_A 293_V 1.201 0.66
249_N 253_D 1.178 0.64
157_N 223_W 1.173 0.63
33_T 37_H 1.167 0.63
100_P 222_K 1.158 0.62
173_L 177_Y 1.151 0.61
171_L 175_T 1.149 0.61
198_C 243_M 1.145 0.61
133_I 165_A 1.144 0.60
106_G 217_R 1.142 0.60
218_A 231_L 1.133 0.59
67_I 94_V 1.131 0.59
91_V 110_A 1.123 0.58
95_S 148_A 1.121 0.58
113_V 133_I 1.117 0.58
171_L 195_A 1.116 0.58
220_V 224_Q 1.112 0.57
197_F 243_M 1.112 0.57
175_T 193_L 1.11 0.57
46_Q 50_E 1.102 0.56
199_R 242_A 1.097 0.56
82_E 86_R 1.096 0.56
241_F 291_Q 1.093 0.55
251_A 277_V 1.082 0.54
114_A 148_A 1.082 0.54
277_V 285_S 1.076 0.53
126_K 223_W 1.075 0.53
51_V 297_A 1.072 0.53
35_I 85_G 1.071 0.53
186_I 218_A 1.067 0.53
211_S 214_E 1.052 0.51
96_R 182_G 1.048 0.51
162_C 165_A 1.04 0.50
173_L 223_W 1.036 0.49
284_D 287_K 1.036 0.49
97_R 197_F 1.033 0.49
259_A 272_F 1.032 0.49
105_A 214_E 1.031 0.49
39_M 290_I 1.028 0.48
237_I 241_F 1.025 0.48
127_V 161_V 1.022 0.48
72_M 103_V 1.022 0.48
140_A 184_P 1.021 0.48
215_I 303_I 1.017 0.47
167_S 203_F 1.016 0.47
146_I 177_Y 1.002 0.46
66_A 76_L 1 0.45
302_E 305_K 1 0.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gimA311000.035Contact Map0.795
4ex8A10.97761000.085Contact Map0.661
1vkmA60.95191000.111Contact Map0.825
2gp4A20.782172.40.968Contact Map0.075
1tksA20.567356.70.971Contact Map0.181
3g8rA20.791756.60.971Contact Map0.075
1vcvA20.477654.20.972Contact Map0.059
1mzhA20.503250.90.972Contact Map0.158
3mwdB10.708349.70.973Contact Map0.222
3pffA10.730843.40.974Contact Map0.262
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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