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OPENSEQ.org
FDHD - Protein FdhD
UniProt: P32177 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11859
Length: 277 (245)
Sequences: 1078
Seq/Len: 4.40
FDHD
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
37_V 247_V 3.626 1.00
64_Y 204_Q 3.446 1.00
237_F 261_C 3.336 1.00
229_A 255_L 3.119 1.00
47_Y 70_S 3.034 1.00
67_L 82_I 2.68 1.00
64_Y 186_H 2.671 1.00
76_I 82_I 2.566 1.00
61_D 64_Y 2.457 1.00
71_L 203_S 2.453 1.00
199_L 231_C 2.437 1.00
177_L 181_E 2.4 1.00
214_V 228_S 2.232 1.00
241_A 260_F 2.1 1.00
184_G 201_R 2.049 1.00
229_A 253_C 2.035 1.00
168_G 269_Y 1.951 1.00
201_R 205_E 1.948 1.00
216_V 224_M 1.934 1.00
256_T 274_R 1.917 1.00
67_L 204_Q 1.813 1.00
104_R 107_G 1.779 1.00
216_V 236_L 1.754 1.00
168_G 260_F 1.744 0.99
186_H 201_R 1.743 0.99
202_R 209_W 1.729 0.99
55_M 65_F 1.722 0.99
251_E 271_H 1.703 0.99
184_G 198_L 1.683 0.99
236_L 255_L 1.677 0.99
235_I 256_T 1.642 0.99
176_M 182_L 1.632 0.99
43_V 57_A 1.624 0.99
258_V 261_C 1.619 0.99
260_F 269_Y 1.578 0.99
173_A 216_V 1.575 0.99
35_D 260_F 1.568 0.99
173_A 194_A 1.521 0.98
145_F 213_A 1.49 0.98
45_L 66_A 1.483 0.98
35_D 267_T 1.473 0.98
251_E 270_T 1.45 0.97
164_G 260_F 1.425 0.97
176_M 213_A 1.419 0.97
195_L 214_V 1.418 0.97
116_A 120_G 1.39 0.96
78_S 81_D 1.381 0.96
190_G 193_V 1.372 0.96
77_E 107_G 1.356 0.96
177_L 183_V 1.354 0.96
66_A 96_V 1.34 0.95
213_A 235_I 1.34 0.95
39_E 244_T 1.337 0.95
64_Y 201_R 1.332 0.95
46_V 95_E 1.331 0.95
217_S 267_T 1.325 0.95
71_L 199_L 1.311 0.95
43_V 66_A 1.309 0.94
258_V 268_V 1.285 0.94
41_V 94_L 1.285 0.94
35_D 259_G 1.284 0.94
133_G 252_R 1.284 0.94
168_G 259_G 1.277 0.94
153_A 213_A 1.264 0.93
156_H 159_D 1.259 0.93
199_L 233_V 1.252 0.93
220_A 260_F 1.242 0.92
66_A 94_L 1.229 0.92
53_V 69_F 1.223 0.91
244_T 248_E 1.22 0.91
154_L 261_C 1.208 0.91
35_D 217_S 1.206 0.91
85_M 98_I 1.202 0.90
248_E 252_R 1.202 0.90
217_S 260_F 1.2 0.90
57_A 62_L 1.19 0.90
77_E 81_D 1.186 0.90
167_T 260_F 1.182 0.90
69_F 74_G 1.171 0.89
183_V 201_R 1.169 0.89
175_W 202_R 1.166 0.89
43_V 62_L 1.162 0.88
82_I 100_L 1.149 0.88
44_A 51_S 1.148 0.88
260_F 267_T 1.135 0.87
157_L 217_S 1.134 0.87
82_I 98_I 1.123 0.86
141_F 210_Q 1.121 0.86
138_P 208_S 1.119 0.86
150_L 261_C 1.102 0.85
216_V 238_A 1.1 0.84
248_E 251_E 1.096 0.84
168_G 217_S 1.09 0.84
258_V 275_L 1.087 0.83
57_A 65_F 1.083 0.83
63_E 85_M 1.082 0.83
152_D 156_H 1.082 0.83
56_M 123_V 1.081 0.83
220_A 238_A 1.078 0.83
259_G 269_Y 1.065 0.82
38_A 170_T 1.061 0.81
83_F 102_S 1.056 0.81
132_I 236_L 1.056 0.81
175_W 212_G 1.048 0.80
35_D 168_G 1.042 0.80
67_L 203_S 1.04 0.80
79_P 275_L 1.037 0.79
83_F 99_E 1.036 0.79
145_F 237_F 1.033 0.79
61_D 186_H 1.027 0.78
79_P 204_Q 1.027 0.78
67_L 76_I 1.025 0.78
174_A 182_L 1.023 0.78
70_S 98_I 1.02 0.78
235_I 274_R 1.006 0.76
208_S 211_Q 1.006 0.76
74_G 229_A 1.004 0.76
160_F 182_L 1.002 0.76
186_H 238_A 1.002 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2pw9A40.92781000.203Contact Map0.743
2yv1A10.476544.80.96Contact Map0.4
2yv2A10.472943.50.961Contact Map0.312
3mtjA10.498240.70.961Contact Map0.254
2fp4A10.480138.60.962Contact Map0.287
3d0cA20.407934.80.963Contact Map0.157
3e96A20.407929.30.964Contact Map0.159
1oi7A10.454929.20.964Contact Map0.372
2wkjA40.400723.30.966Contact Map0.231
3i23A20.458521.90.966Contact Map0.446
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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