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OPENSEQ.org
YIIM - Protein YiiM
UniProt: P32157 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11870
Length: 224 (222)
Sequences: 649
Seq/Len: 2.92
YIIM
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
103_I 112_Q 4.421 1.00
31_E 155_S 2.769 1.00
105_R 150_A 2.725 1.00
110_L 163_V 2.656 1.00
59_H 146_Y 2.52 1.00
55_R 145_L 2.507 1.00
110_L 150_A 2.465 1.00
98_V 104_F 2.366 1.00
106_W 160_L 2.363 1.00
71_E 135_L 2.271 1.00
105_R 161_E 2.184 1.00
36_E 151_P 2.136 1.00
60_Y 68_W 2.062 1.00
11_K 43_E 2.034 1.00
109_A 154_V 2.003 1.00
34_L 109_A 1.93 0.99
202_T 206_Q 1.926 0.99
162_L 165_R 1.898 0.99
8_Y 89_S 1.82 0.99
174_A 191_L 1.812 0.99
103_I 149_I 1.801 0.99
63_E 92_G 1.786 0.99
112_Q 149_I 1.777 0.99
106_W 154_V 1.765 0.99
57_L 111_I 1.743 0.99
105_R 110_L 1.694 0.98
112_Q 147_S 1.655 0.98
173_E 190_R 1.654 0.98
127_F 132_I 1.628 0.98
59_H 90_T 1.619 0.97
37_L 47_K 1.611 0.97
34_L 111_I 1.604 0.97
88_L 154_V 1.586 0.97
64_H 95_E 1.584 0.97
21_S 24_A 1.541 0.96
169_V 173_E 1.54 0.96
12_I 43_E 1.539 0.96
88_L 106_W 1.538 0.96
22_A 43_E 1.534 0.96
108_E 153_K 1.518 0.96
34_L 154_V 1.497 0.95
124_N 133_A 1.464 0.95
94_T 97_N 1.443 0.94
34_L 39_L 1.4 0.93
7_V 32_L 1.385 0.92
33_M 40_E 1.377 0.92
61_P 64_H 1.373 0.92
54_D 147_S 1.37 0.92
32_L 39_L 1.34 0.90
33_M 108_E 1.339 0.90
96_S 172_Q 1.336 0.90
206_Q 210_L 1.323 0.90
155_S 158_A 1.317 0.89
181_M 184_D 1.308 0.89
169_V 194_A 1.298 0.88
98_V 146_Y 1.288 0.88
105_R 163_V 1.283 0.88
55_R 118_S 1.282 0.88
114_S 147_S 1.276 0.87
156_A 160_L 1.249 0.86
46_E 49_V 1.247 0.86
99_Y 170_T 1.24 0.85
58_C 136_M 1.236 0.85
63_E 90_T 1.235 0.85
61_P 95_E 1.202 0.83
23_I 85_G 1.197 0.82
108_E 158_A 1.195 0.82
45_A 122_K 1.192 0.82
55_R 114_S 1.169 0.80
65_Y 89_S 1.169 0.80
100_M 195_A 1.169 0.80
57_L 154_V 1.168 0.80
59_H 113_V 1.163 0.80
110_L 149_I 1.153 0.79
33_M 39_L 1.127 0.77
13_Q 24_A 1.126 0.77
177_I 191_L 1.121 0.76
12_I 22_A 1.112 0.75
44_Q 122_K 1.107 0.75
108_E 150_A 1.106 0.75
99_Y 102_D 1.106 0.75
106_W 111_I 1.105 0.75
7_V 39_L 1.091 0.73
82_P 126_H 1.091 0.73
188_Y 205_M 1.091 0.73
115_Q 198_S 1.09 0.73
54_D 199_K 1.086 0.73
82_P 145_L 1.084 0.73
100_M 174_A 1.081 0.72
61_P 94_T 1.078 0.72
55_R 122_K 1.077 0.72
99_Y 167_S 1.067 0.71
95_E 102_D 1.066 0.71
44_Q 47_K 1.064 0.71
30_G 156_A 1.064 0.71
185_D 189_H 1.061 0.70
131_D 135_L 1.048 0.69
8_Y 82_P 1.045 0.69
55_R 115_Q 1.038 0.68
68_W 84_F 1.035 0.68
123_L 136_M 1.018 0.66
218_S 222_W 1.013 0.65
116_P 198_S 1.008 0.65
68_W 141_K 1.008 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1o65A311000.259Contact Map0.733
1oruA20.73661000.572Contact Map0.612
1y8oB10.553653.20.955Contact Map0.103
3crkC20.370552.60.955Contact Map0.115
2l5tA10.334814.90.966Contact Map0.079
2dneA10.464312.10.967Contact Map0.108
2kccA10.3661120.967Contact Map0.084
1d9nA10.169611.60.968Contact Map0
2d5dA20.321411.10.968Contact Map0.136
1ghjA10.343810.30.968Contact Map0.083
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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