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OPENSEQ.org
YIHS - Uncharacterized sugar isomerase YihS
UniProt: P32140 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11845
Length: 413 (385)
Sequences: 691
Seq/Len: 1.79
YIHS
Paralog alert: 0.21 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
221_D 225_N 3.356 1.00
57_L 78_G 2.857 1.00
37_G 41_Q 2.554 1.00
69_P 73_S 2.334 1.00
365_D 369_K 2.324 1.00
202_S 206_H 2.302 1.00
25_K 74_L 2.299 1.00
23_F 40_G 2.206 0.99
61_S 75_V 2.135 0.99
91_Y 160_E 2.123 0.99
176_H 179_E 2.052 0.99
87_R 137_Y 2.038 0.99
76_D 128_H 1.975 0.99
99_N 103_V 1.966 0.98
291_A 313_R 1.952 0.98
64_A 72_Y 1.931 0.98
133_K 137_Y 1.874 0.98
303_D 307_K 1.839 0.97
114_F 180_A 1.831 0.97
80_K 84_G 1.82 0.97
88_D 108_K 1.77 0.96
322_M 348_C 1.769 0.96
291_A 296_D 1.754 0.96
88_D 95_Y 1.748 0.96
50_L 86_L 1.743 0.96
282_F 325_A 1.736 0.96
75_V 78_G 1.728 0.96
260_H 331_V 1.702 0.95
179_E 255_L 1.697 0.95
93_G 108_K 1.663 0.94
159_D 163_S 1.656 0.94
311_R 366_A 1.641 0.94
335_R 339_T 1.557 0.92
111_Y 172_N 1.541 0.91
106_A 160_E 1.525 0.90
50_L 82_M 1.524 0.90
50_L 112_Q 1.517 0.90
76_D 80_K 1.512 0.90
62_V 122_S 1.508 0.90
297_G 313_R 1.497 0.89
148_S 151_E 1.494 0.89
253_G 282_F 1.487 0.89
329_Y 338_E 1.482 0.89
111_Y 179_E 1.465 0.88
340_W 343_T 1.458 0.88
51_W 112_Q 1.446 0.87
115_F 175_M 1.427 0.86
57_L 79_I 1.427 0.86
172_N 179_E 1.427 0.86
94_W 138_T 1.426 0.86
115_F 251_E 1.406 0.85
375_W 378_K 1.404 0.85
143_E 154_C 1.393 0.84
175_M 218_E 1.389 0.84
97_C 104_V 1.376 0.83
198_I 266_R 1.35 0.81
191_K 287_R 1.348 0.81
129_P 195_D 1.344 0.81
172_N 255_L 1.343 0.81
336_Q 339_T 1.332 0.80
198_I 271_P 1.326 0.80
216_V 252_W 1.316 0.79
354_D 378_K 1.315 0.79
76_D 129_P 1.315 0.79
95_Y 108_K 1.312 0.79
64_A 75_V 1.291 0.77
29_V 48_T 1.289 0.77
124_V 186_D 1.281 0.76
111_Y 248_H 1.277 0.76
87_R 139_I 1.271 0.76
175_M 251_E 1.266 0.75
48_T 81_A 1.262 0.75
34_G 49_H 1.256 0.74
230_Y 240_R 1.252 0.74
248_H 251_E 1.233 0.73
9_H 12_W 1.231 0.72
31_T 100_D 1.229 0.72
244_G 249_W 1.22 0.71
382_Y 385_L 1.219 0.71
18_D 356_E 1.218 0.71
108_K 113_H 1.218 0.71
178_V 259_I 1.216 0.71
185_Y 194_L 1.214 0.71
176_H 255_L 1.21 0.71
10_N 14_E 1.21 0.71
201_A 259_I 1.21 0.71
143_E 196_R 1.206 0.70
47_G 97_C 1.203 0.70
111_Y 115_F 1.203 0.70
185_Y 188_T 1.202 0.70
195_D 336_Q 1.2 0.70
63_A 71_A 1.199 0.70
235_P 238_R 1.199 0.70
88_D 93_G 1.197 0.69
84_G 333_G 1.193 0.69
176_H 251_E 1.189 0.69
215_R 288_D 1.185 0.68
122_S 183_I 1.182 0.68
191_K 195_D 1.18 0.68
83_N 134_L 1.178 0.68
63_A 385_L 1.174 0.67
188_T 193_W 1.172 0.67
279_K 334_D 1.169 0.67
72_Y 129_P 1.166 0.66
169_R 197_A 1.161 0.66
140_E 192_K 1.16 0.66
23_F 127_G 1.156 0.65
153_M 203_V 1.154 0.65
115_F 248_H 1.153 0.65
200_V 310_V 1.15 0.65
202_S 287_R 1.145 0.64
21_F 63_A 1.144 0.64
289_A 298_I 1.14 0.64
111_Y 176_H 1.14 0.64
172_N 382_Y 1.136 0.63
378_K 383_H 1.136 0.63
376_D 379_Q 1.135 0.63
351_Y 364_L 1.132 0.63
187_V 190_D 1.131 0.63
175_M 246_P 1.13 0.63
72_Y 125_T 1.126 0.62
58_H 63_A 1.124 0.62
53_T 86_L 1.121 0.62
292_P 334_D 1.116 0.61
296_D 313_R 1.111 0.61
275_L 332_T 1.109 0.61
181_F 184_V 1.107 0.60
33_F 78_G 1.102 0.60
82_M 116_A 1.096 0.59
111_Y 255_L 1.094 0.59
234_N 237_H 1.094 0.59
300_Y 310_V 1.092 0.59
384_L 388_L 1.091 0.59
314_V 362_Q 1.089 0.59
290_W 297_G 1.087 0.58
226_P 229_D 1.086 0.58
51_W 250_I 1.084 0.58
75_V 128_H 1.083 0.58
364_L 368_N 1.082 0.58
28_V 74_L 1.081 0.58
381_I 385_L 1.076 0.57
379_Q 385_L 1.075 0.57
322_M 325_A 1.075 0.57
378_K 386_H 1.074 0.57
23_F 36_L 1.069 0.56
114_F 119_G 1.066 0.56
86_L 94_W 1.066 0.56
378_K 385_L 1.063 0.56
210_R 217_N 1.058 0.55
59_V 63_A 1.055 0.55
92_G 137_Y 1.048 0.54
286_V 343_T 1.047 0.54
96_A 112_Q 1.044 0.54
116_A 169_R 1.043 0.54
39_K 311_R 1.042 0.54
218_E 248_H 1.039 0.53
205_I 277_D 1.039 0.53
94_W 112_Q 1.037 0.53
175_M 248_H 1.036 0.53
81_A 86_L 1.033 0.53
287_R 336_Q 1.033 0.53
94_W 116_A 1.033 0.53
286_V 340_W 1.031 0.52
114_F 255_L 1.03 0.52
119_G 183_I 1.03 0.52
284_A 288_D 1.029 0.52
80_K 195_D 1.029 0.52
144_K 342_Q 1.027 0.52
347_Y 368_N 1.021 0.51
342_Q 346_E 1.021 0.51
251_E 255_L 1.02 0.51
171_G 252_W 1.018 0.51
104_V 211_N 1.016 0.51
250_I 298_I 1.014 0.51
118_L 175_M 1.013 0.50
140_E 361_W 1.012 0.50
86_L 98_V 1.011 0.50
30_P 48_T 1.011 0.50
362_Q 375_W 1.008 0.50
30_P 137_Y 1.008 0.50
24_G 254_R 1.008 0.50
129_P 133_K 1.008 0.50
172_N 176_H 1.007 0.50
88_D 91_Y 1.006 0.50
135_L 188_T 1.005 0.50
38_N 356_E 1.003 0.49
115_F 179_E 1.001 0.49
57_L 119_G 1.001 0.49
179_E 251_E 1 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2zblA60.99031000.333Contact Map0.619
3gt5A10.95641000.433Contact Map0.564
3vw5A30.88381000.498Contact Map0.584
1fp3A20.91041000.517Contact Map0.557
2gz6A20.90071000.528Contact Map0.578
4mu9A20.736199.80.814Contact Map0.437
3k11A10.813699.80.824Contact Map0.33
3pmmA10.772499.80.832Contact Map0.395
3k7xA10.714399.80.834Contact Map0.398
2ahfA20.714399.70.844Contact Map0.4
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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