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OPENSEQ.org
NUOF - NADH-quinone oxidoreductase subunit F
UniProt: P31979 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11774
Length: 445 (411)
Sequences: 1615
Seq/Len: 3.93
NUOF
Paralog alert: 0.48 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
52_N 56_D 4.527 1.00
88_L 187_I 3.671 1.00
158_K 166_D 3.54 1.00
151_T 168_E 3.524 1.00
334_N 422_G 3.491 1.00
159_N 164_G 3.392 1.00
55_K 74_S 3.13 1.00
252_F 278_A 2.979 1.00
237_Q 245_A 2.859 1.00
301_T 414_Y 2.789 1.00
183_E 204_P 2.668 1.00
84_I 126_Y 2.64 1.00
285_L 331_H 2.617 1.00
53_Q 233_V 2.556 1.00
35_Y 110_H 2.496 1.00
271_R 306_D 2.48 1.00
411_A 419_F 2.442 1.00
363_W 366_K 2.426 1.00
144_R 148_A 2.392 1.00
30_R 39_R 2.375 1.00
128_G 167_F 2.368 1.00
46_S 49_E 2.331 1.00
56_D 234_E 2.327 1.00
385_E 416_R 2.217 1.00
285_L 332_E 2.193 1.00
29_Y 34_G 2.184 1.00
231_N 235_W 2.157 1.00
378_P 424_K 2.137 1.00
37_G 229_L 2.105 1.00
416_R 420_E 2.1 1.00
127_R 170_F 2.082 1.00
183_E 203_F 2.078 1.00
89_C 116_M 2.015 1.00
48_D 77_P 2.001 1.00
255_R 333_I 1.916 1.00
83_N 212_K 1.892 1.00
38_A 117_L 1.878 1.00
50_I 121_F 1.875 1.00
288_K 418_E 1.869 1.00
301_T 304_H 1.854 1.00
227_A 235_W 1.847 1.00
235_W 238_N 1.837 1.00
74_S 78_K 1.802 0.99
30_R 155_L 1.794 0.99
26_L 153_A 1.794 0.99
310_E 313_S 1.79 0.99
48_D 52_N 1.789 0.99
113_V 169_L 1.77 0.99
292_P 319_S 1.769 0.99
307_L 317_A 1.764 0.99
140_A 173_T 1.752 0.99
116_M 128_G 1.745 0.99
364_S 384_L 1.741 0.99
56_D 233_V 1.7 0.99
243_K 312_E 1.7 0.99
27_D 30_R 1.691 0.99
76_M 215_C 1.682 0.99
379_G 382_E 1.672 0.99
295_A 346_F 1.648 0.99
128_G 169_L 1.64 0.99
163_T 166_D 1.634 0.99
33_N 230_A 1.602 0.99
233_V 237_Q 1.601 0.99
52_N 55_K 1.592 0.98
126_Y 166_D 1.588 0.98
369_R 373_R 1.584 0.98
148_A 152_E 1.572 0.98
55_K 71_L 1.566 0.98
69_T 221_T 1.549 0.98
361_L 404_A 1.541 0.98
187_I 216_V 1.538 0.98
417_E 420_E 1.532 0.98
227_A 231_N 1.531 0.98
87_L 119_S 1.531 0.98
286_K 302_E 1.523 0.98
56_D 237_Q 1.519 0.98
257_K 284_G 1.517 0.98
204_P 216_V 1.502 0.97
132_L 143_L 1.496 0.97
27_D 153_A 1.492 0.97
36_E 39_R 1.482 0.97
132_L 140_A 1.481 0.97
49_E 52_N 1.475 0.97
299_F 335_M 1.457 0.97
33_N 36_E 1.455 0.97
129_Y 170_F 1.446 0.97
385_E 413_K 1.438 0.97
54_V 122_A 1.408 0.96
353_W 397_F 1.404 0.96
53_Q 56_D 1.401 0.96
91_A 219_V 1.379 0.95
26_L 155_L 1.376 0.95
30_R 153_A 1.375 0.95
119_S 222_L 1.375 0.95
272_E 276_D 1.369 0.95
269_T 272_E 1.364 0.95
190_L 209_A 1.362 0.95
158_K 168_E 1.361 0.95
24_V 142_N 1.358 0.95
304_H 414_Y 1.357 0.95
127_R 168_E 1.352 0.95
378_P 382_E 1.339 0.94
372_E 422_G 1.335 0.94
286_K 331_H 1.327 0.94
234_E 238_N 1.321 0.94
75_L 203_F 1.321 0.94
273_I 309_M 1.318 0.94
120_A 167_F 1.317 0.94
130_I 143_L 1.316 0.94
282_R 330_D 1.31 0.93
421_A 425_Q 1.306 0.93
75_L 205_A 1.29 0.93
371_L 376_G 1.288 0.93
81_S 84_I 1.265 0.92
71_L 74_S 1.252 0.91
188_N 193_R 1.251 0.91
69_T 217_N 1.245 0.91
91_A 143_L 1.242 0.91
318_G 413_K 1.237 0.90
138_E 142_N 1.233 0.90
53_Q 234_E 1.231 0.90
54_V 225_V 1.231 0.90
41_A 50_I 1.23 0.90
89_C 222_L 1.224 0.90
34_G 111_L 1.215 0.89
249_L 261_L 1.215 0.89
271_R 305_L 1.205 0.89
148_A 151_T 1.204 0.89
256_V 328_A 1.204 0.89
40_K 45_L 1.202 0.89
145_R 149_E 1.198 0.88
329_V 333_I 1.189 0.88
50_I 122_A 1.186 0.88
383_T 386_Q 1.183 0.88
47_P 121_F 1.18 0.87
95_E 100_K 1.18 0.87
367_I 370_A 1.178 0.87
340_R 369_R 1.176 0.87
57_A 69_T 1.172 0.87
289_A 335_M 1.167 0.87
37_G 230_A 1.166 0.87
120_A 169_L 1.163 0.86
84_I 127_R 1.163 0.86
241_K 244_D 1.159 0.86
143_L 171_V 1.155 0.86
201_P 204_P 1.154 0.86
220_E 248_K 1.152 0.86
337_S 372_E 1.144 0.85
329_V 338_L 1.132 0.84
377_Q 423_I 1.131 0.84
183_E 216_V 1.129 0.84
365_V 369_R 1.127 0.84
187_I 209_A 1.125 0.84
120_A 128_G 1.121 0.84
183_E 205_A 1.12 0.83
304_H 317_A 1.12 0.83
287_F 305_L 1.119 0.83
123_L 215_C 1.119 0.83
420_E 424_K 1.116 0.83
340_R 365_V 1.115 0.83
45_L 54_V 1.112 0.83
40_K 229_L 1.109 0.83
105_M 112_L 1.109 0.83
370_A 377_Q 1.102 0.82
257_K 283_D 1.099 0.82
105_M 143_L 1.094 0.81
147_I 171_V 1.094 0.81
88_L 186_L 1.091 0.81
113_V 130_I 1.087 0.81
300_L 317_A 1.086 0.81
50_I 229_L 1.083 0.81
183_E 202_P 1.073 0.80
184_T 204_P 1.073 0.80
370_A 375_E 1.073 0.80
304_H 307_L 1.072 0.80
269_T 308_P 1.071 0.80
51_V 77_P 1.07 0.79
291_Q 342_L 1.068 0.79
273_I 326_A 1.065 0.79
382_E 385_E 1.064 0.79
144_R 171_V 1.061 0.79
75_L 183_E 1.056 0.78
183_E 187_I 1.053 0.78
370_A 380_D 1.052 0.78
385_E 412_I 1.052 0.78
389_R 394_G 1.051 0.78
188_N 198_R 1.051 0.78
51_V 122_A 1.048 0.77
160_I 166_D 1.047 0.77
76_M 123_L 1.047 0.77
340_R 372_E 1.045 0.77
281_M 287_F 1.039 0.77
39_R 43_T 1.038 0.76
40_K 53_Q 1.037 0.76
87_L 120_A 1.034 0.76
113_V 147_I 1.034 0.76
131_F 189_S 1.025 0.75
38_A 161_M 1.02 0.75
71_L 75_L 1.02 0.75
399_A 402_P 1.019 0.75
60_K 312_E 1.016 0.74
392_G 409_Q 1.016 0.74
65_A 312_E 1.015 0.74
302_E 305_L 1.014 0.74
340_R 344_E 1.012 0.74
160_I 163_T 1.011 0.74
24_V 145_R 1.009 0.74
355_T 359_D 1.009 0.74
242_S 245_A 1.008 0.73
255_R 330_D 1.008 0.73
283_D 286_K 1.007 0.73
243_K 316_K 1.003 0.73
117_L 161_M 1 0.73
147_I 151_T 1 0.73
28_E 32_K 1 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3i9v120.96631000.246Contact Map0.75
3c8yA10.393397.50.951Contact Map0.166
3p42A40.4562420.978Contact Map0.303
3pjxA10.485415.50.983Contact Map0.238
1rm6C20.359614.10.983Contact Map0.301
1t3qA20.370812.70.983Contact Map0.279
1vlbA10.406711.30.984Contact Map0.404
1ffvA20.366310.90.984Contact Map0.362
4fojA10.487610.20.984Contact Map0.107
3qouA10.258410.10.984Contact Map0.122
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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