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OPENSEQ.org
NNR - Bifunctional NAD(P)H-hydrate repair enzyme Nnr
UniProt: P31806 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11758
Length: 515 (488)
Sequences: 1569
Seq/Len: 3.22
NNR
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_G 136_A 6.158 1.00
410_V 466_C 5.418 1.00
325_V 445_S 5.368 1.00
46_G 78_V 4.459 1.00
325_V 449_G 4.349 1.00
146_P 154_I 3.907 1.00
432_N 474_D 3.259 1.00
448_I 465_G 3.243 1.00
261_G 270_I 3.216 1.00
43_L 81_R 3.2 1.00
144_Q 147_R 3.198 1.00
257_L 449_G 3.185 1.00
398_A 417_V 3.018 1.00
49_A 167_V 2.968 1.00
331_G 355_D 2.94 1.00
393_D 396_H 2.862 1.00
66_L 157_A 2.693 1.00
256_R 286_R 2.589 1.00
53_C 165_V 2.561 1.00
430_A 470_G 2.552 1.00
112_W 117_G 2.486 1.00
209_T 212_L 2.449 1.00
79_V 167_V 2.413 1.00
77_Y 94_A 2.406 1.00
56_A 211_Q 2.36 1.00
48_A 215_D 2.324 1.00
50_F 79_V 2.252 1.00
435_M 440_M 2.249 1.00
440_M 490_L 2.235 1.00
157_A 185_I 2.202 1.00
28_R 32_D 2.181 1.00
67_C 76_G 2.18 1.00
38_L 104_E 2.148 1.00
352_W 356_A 2.136 1.00
157_A 164_I 2.102 1.00
138_L 144_Q 2.1 1.00
136_A 167_V 2.084 1.00
332_Q 358_N 2.08 1.00
200_L 209_T 2.07 1.00
274_G 304_L 2.051 1.00
20_A 176_E 2.018 1.00
379_A 383_L 1.999 1.00
137_L 154_I 1.99 1.00
138_L 147_R 1.986 1.00
445_S 449_G 1.98 1.00
154_I 158_N 1.979 1.00
155_D 183_A 1.964 1.00
95_Q 137_L 1.96 1.00
280_A 447_I 1.96 1.00
178_G 199_G 1.946 1.00
435_M 473_A 1.93 1.00
280_A 450_A 1.927 1.00
358_N 381_R 1.898 0.99
42_M 74_G 1.879 0.99
475_V 497_I 1.861 0.99
65_V 80_A 1.855 0.99
189_H 213_H 1.854 0.99
379_A 401_L 1.852 0.99
52_V 191_I 1.851 0.99
284_L 438_G 1.843 0.99
164_I 185_I 1.827 0.99
282_A 285_V 1.826 0.99
53_C 132_L 1.814 0.99
52_V 213_H 1.813 0.99
174_L 181_P 1.809 0.99
447_I 494_L 1.789 0.99
380_A 390_I 1.759 0.99
148_E 152_Q 1.744 0.99
138_L 142_L 1.734 0.99
276_A 491_F 1.726 0.99
410_V 448_I 1.72 0.99
49_A 79_V 1.718 0.99
401_L 409_A 1.713 0.99
190_T 210_G 1.706 0.99
371_V 448_I 1.696 0.99
257_L 282_A 1.685 0.98
19_Y 22_D 1.672 0.98
63_W 88_I 1.659 0.98
163_P 188_D 1.658 0.98
53_C 79_V 1.648 0.98
426_G 463_C 1.641 0.98
437_S 487_A 1.627 0.98
272_M 488_T 1.625 0.98
199_G 205_A 1.62 0.98
53_C 134_V 1.598 0.98
447_I 465_G 1.596 0.98
428_I 470_G 1.595 0.98
455_K 461_A 1.566 0.97
400_R 404_R 1.562 0.97
64_L 130_V 1.523 0.97
191_I 215_D 1.513 0.96
79_V 134_V 1.511 0.96
196_L 214_F 1.509 0.96
457_S 460_D 1.506 0.96
106_A 110_E 1.5 0.96
286_R 305_M 1.497 0.96
279_R 489_D 1.494 0.96
21_D 25_R 1.493 0.96
386_S 389_E 1.492 0.96
52_V 189_H 1.474 0.96
261_G 328_P 1.472 0.96
274_G 287_V 1.466 0.96
256_R 322_D 1.466 0.96
180_T 184_V 1.465 0.96
65_V 76_G 1.453 0.95
154_I 171_S 1.45 0.95
279_R 486_L 1.445 0.95
434_G 474_D 1.431 0.95
53_C 56_A 1.418 0.94
277_A 285_V 1.416 0.94
56_A 189_H 1.416 0.94
301_R 304_L 1.415 0.94
408_V 462_A 1.414 0.94
18_W 23_I 1.409 0.94
78_V 81_R 1.407 0.94
356_A 360_L 1.4 0.94
20_A 175_A 1.39 0.94
80_A 92_L 1.37 0.93
272_M 443_V 1.361 0.93
184_V 208_V 1.355 0.92
401_L 407_G 1.348 0.92
486_L 489_D 1.348 0.92
173_L 184_V 1.344 0.92
326_I 352_W 1.335 0.92
476_L 489_D 1.331 0.92
323_V 449_G 1.323 0.91
243_K 456_L 1.322 0.91
67_C 136_A 1.321 0.91
328_P 445_S 1.318 0.91
266_T 305_M 1.318 0.91
165_V 189_H 1.311 0.91
149_S 152_Q 1.307 0.91
196_L 212_L 1.302 0.90
257_L 323_V 1.296 0.90
257_L 277_A 1.294 0.90
383_L 401_L 1.291 0.90
69_H 144_Q 1.284 0.89
180_T 208_V 1.283 0.89
379_A 411_L 1.282 0.89
340_L 359_L 1.28 0.89
252_G 376_P 1.275 0.89
249_S 254_H 1.269 0.89
43_L 78_V 1.268 0.89
459_Y 463_C 1.261 0.88
434_G 485_M 1.254 0.88
398_A 402_V 1.247 0.88
47_E 82_L 1.239 0.87
18_W 195_A 1.237 0.87
138_L 171_S 1.235 0.87
376_P 394_R 1.224 0.86
259_I 270_I 1.223 0.86
31_A 38_L 1.223 0.86
379_A 397_C 1.214 0.86
194_I 219_L 1.204 0.85
303_E 488_T 1.198 0.85
205_A 209_T 1.195 0.84
54_R 86_V 1.192 0.84
49_A 191_I 1.189 0.84
158_N 185_I 1.185 0.84
62_H 131_D 1.17 0.83
333_Q 336_G 1.164 0.82
351_L 465_G 1.164 0.82
476_L 493_T 1.163 0.82
267_A 298_L 1.162 0.82
437_S 440_M 1.16 0.82
174_L 177_T 1.16 0.82
109_R 113_L 1.151 0.81
256_R 284_L 1.15 0.81
371_V 452_L 1.149 0.81
108_A 111_A 1.147 0.81
258_V 288_L 1.143 0.81
270_I 287_V 1.14 0.80
400_R 403_Q 1.138 0.80
192_T 214_F 1.137 0.80
401_L 405_Y 1.137 0.80
467_V 471_A 1.134 0.80
69_H 96_E 1.133 0.80
430_A 467_V 1.128 0.79
372_I 409_A 1.126 0.79
47_E 51_Q 1.123 0.79
62_H 89_E 1.123 0.79
29_E 33_V 1.111 0.78
39_Y 108_A 1.099 0.77
57_Y 165_V 1.098 0.77
151_S 155_D 1.095 0.76
196_L 201_L 1.091 0.76
25_R 28_R 1.083 0.75
67_C 77_Y 1.08 0.75
173_L 208_V 1.076 0.75
133_I 157_A 1.073 0.74
475_V 493_T 1.07 0.74
151_S 183_A 1.067 0.74
144_Q 148_E 1.064 0.74
245_R 254_H 1.063 0.73
173_L 180_T 1.061 0.73
49_A 53_C 1.059 0.73
289_T 297_L 1.059 0.73
398_A 419_A 1.059 0.73
394_R 413_G 1.058 0.73
275_E 492_S 1.057 0.73
332_Q 355_D 1.05 0.72
27_E 38_L 1.045 0.72
278_L 486_L 1.043 0.71
358_N 361_A 1.04 0.71
65_V 136_A 1.04 0.71
80_A 90_V 1.038 0.71
25_R 29_E 1.038 0.71
142_L 181_P 1.037 0.71
479_R 493_T 1.037 0.71
431_G 474_D 1.036 0.71
435_M 474_D 1.032 0.70
284_L 305_M 1.03 0.70
351_L 445_S 1.026 0.70
259_I 273_T 1.022 0.69
18_W 26_G 1.017 0.69
257_L 285_V 1.016 0.69
194_I 216_S 1.014 0.68
371_V 410_V 1.013 0.68
64_L 93_L 1.005 0.67
44_R 82_L 1.003 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rssA10.94171000.291Contact Map0.808
3k5wA10.90291000.309Contact Map0.715
1jztA20.4331000.652Contact Map0.68
3bgkA10.57861000.659Contact Map0.711
2o8nA10.46411000.666Contact Map0.773
3rpzA10.53791000.671Contact Map0.761
3d3kA40.44471000.685Contact Map0.749
2r3bA20.58061000.686Contact Map0.803
3d3jA10.44471000.686Contact Map0.725
3nl6A30.83881000.804Contact Map0.491
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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