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OPENSEQ.org
LPTD - LPS-assembly protein LptD
UniProt: P31554 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11569
Length: 784 (729)
Sequences: 798
Seq/Len: 1.09
LPTD
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
226_S 247_Y 5.779 1.00
251_I 255_M 3.664 1.00
85_D 109_N 3.54 1.00
122_P 137_E 3.157 1.00
228_F 247_Y 3.042 1.00
558_V 585_F 2.794 1.00
173_C 725_C 2.775 1.00
456_T 480_R 2.594 1.00
527_N 530_S 2.577 1.00
512_A 560_T 2.576 1.00
152_D 167_N 2.576 1.00
372_V 394_L 2.576 1.00
228_F 245_L 2.524 0.99
257_A 274_N 2.521 0.99
653_Q 688_V 2.493 0.99
278_Y 285_G 2.457 0.99
249_W 259_I 2.456 0.99
488_D 511_R 2.449 0.99
310_R 336_D 2.446 0.99
244_Y 260_T 2.404 0.99
255_M 276_F 2.338 0.99
234_K 242_E 2.306 0.99
730_V 752_I 2.247 0.98
198_I 218_L 2.178 0.98
242_E 262_H 2.156 0.98
185_S 200_N 2.151 0.98
285_G 317_H 2.096 0.97
57_D 72_S 2.081 0.97
90_H 101_V 2.056 0.97
205_V 210_I 2.049 0.97
278_Y 317_H 2.041 0.97
540_L 580_G 2.022 0.96
333_K 357_Q 1.999 0.96
107_L 123_K 1.958 0.96
700_V 718_G 1.938 0.95
529_D 548_G 1.933 0.95
164_I 168_G 1.911 0.95
450_E 486_K 1.808 0.92
147_G 170_F 1.796 0.92
106_A 110_V 1.782 0.92
85_D 108_G 1.781 0.92
73_V 87_V 1.777 0.91
229_L 256_D 1.761 0.91
514_Y 556_N 1.751 0.91
447_I 489_G 1.734 0.90
429_R 550_D 1.734 0.90
256_D 277_R 1.732 0.90
224_R 256_D 1.713 0.89
275_E 286_L 1.704 0.89
181_S 204_K 1.698 0.89
431_H 549_L 1.691 0.89
87_V 106_A 1.687 0.88
433_E 452_K 1.686 0.88
246_P 261_P 1.675 0.88
478_V 525_I 1.637 0.86
194_Q 221_G 1.632 0.86
529_D 550_D 1.631 0.86
185_S 202_R 1.622 0.86
103_T 125_W 1.61 0.85
194_Q 223_K 1.605 0.85
257_A 275_E 1.584 0.84
259_I 447_I 1.579 0.84
274_N 289_L 1.572 0.83
319_G 327_F 1.562 0.83
446_S 490_K 1.56 0.82
431_H 454_L 1.557 0.82
557_Q 582_I 1.555 0.82
84_A 394_L 1.555 0.82
213_S 216_L 1.547 0.82
227_G 256_D 1.544 0.82
226_S 249_W 1.542 0.81
460_Q 528_Y 1.536 0.81
484_Q 517_V 1.529 0.81
224_R 229_L 1.521 0.80
331_Y 357_Q 1.52 0.80
70_T 86_E 1.513 0.80
328_N 360_S 1.512 0.80
560_T 581_Q 1.506 0.79
103_T 127_N 1.503 0.79
434_P 456_T 1.501 0.79
370_A 396_V 1.499 0.79
195_V 225_R 1.485 0.78
483_P 518_P 1.458 0.76
84_A 87_V 1.455 0.76
84_A 106_A 1.454 0.76
455_A 481_V 1.454 0.76
512_A 558_V 1.442 0.75
77_Q 80_S 1.442 0.75
252_A 255_M 1.442 0.75
247_Y 251_I 1.439 0.75
733_E 751_A 1.439 0.75
106_A 124_G 1.438 0.75
180_W 725_C 1.436 0.75
254_N 278_Y 1.434 0.74
355_A 380_F 1.428 0.74
390_A 393_Q 1.424 0.74
262_H 271_M 1.422 0.74
127_N 130_T 1.403 0.72
140_Y 149_G 1.399 0.72
706_D 709_A 1.397 0.72
266_R 297_V 1.396 0.72
259_I 274_N 1.386 0.71
287_M 315_W 1.383 0.71
86_E 107_L 1.383 0.71
224_R 227_G 1.382 0.71
325_W 540_L 1.382 0.71
189_H 220_V 1.364 0.69
260_T 273_E 1.36 0.69
226_S 250_N 1.36 0.69
361_V 372_V 1.36 0.69
577_I 610_G 1.356 0.68
554_S 590_T 1.344 0.67
85_D 110_V 1.344 0.67
546_Y 554_S 1.336 0.67
689_A 701_G 1.333 0.67
515_L 557_Q 1.332 0.66
703_Y 712_Q 1.316 0.65
200_N 212_Y 1.316 0.65
57_D 71_G 1.312 0.65
77_Q 506_Q 1.31 0.65
728_I 754_F 1.307 0.64
190_D 193_E 1.299 0.64
229_L 277_R 1.299 0.64
378_Q 458_Y 1.296 0.63
339_Y 530_S 1.293 0.63
291_Y 309_R 1.291 0.63
271_M 292_L 1.286 0.62
180_W 721_Y 1.285 0.62
699_I 719_V 1.276 0.62
207_P 637_T 1.275 0.61
283_G 319_G 1.274 0.61
522_Q 551_R 1.274 0.61
773_L 777_I 1.273 0.61
258_T 275_E 1.272 0.61
183_V 204_K 1.272 0.61
271_M 290_D 1.264 0.60
224_R 277_R 1.257 0.60
250_N 255_M 1.257 0.60
275_E 288_E 1.252 0.59
273_E 290_D 1.25 0.59
183_V 202_R 1.249 0.59
486_K 513_Q 1.249 0.59
513_Q 536_D 1.245 0.59
157_R 163_T 1.244 0.59
123_K 136_W 1.24 0.58
251_I 257_A 1.236 0.58
768_G 778_L 1.232 0.58
171_T 629_D 1.229 0.57
452_K 484_Q 1.228 0.57
82_L 574_R 1.226 0.57
69_F 607_V 1.225 0.57
607_V 627_Q 1.223 0.57
182_V 201_A 1.22 0.56
734_R 750_N 1.218 0.56
453_L 481_V 1.216 0.56
68_V 88_Q 1.216 0.56
147_G 378_Q 1.214 0.56
602_K 631_R 1.212 0.56
54_I 69_F 1.21 0.55
429_R 529_D 1.204 0.55
510_P 561_G 1.196 0.54
259_I 730_V 1.196 0.54
650_R 691_W 1.194 0.54
701_G 718_G 1.192 0.54
311_W 333_K 1.192 0.54
310_R 342_D 1.19 0.54
49_D 226_S 1.188 0.53
89_L 102_R 1.188 0.53
249_W 257_A 1.183 0.53
533_L 547_G 1.183 0.53
69_F 724_C 1.181 0.53
582_I 609_A 1.181 0.53
228_F 243_F 1.18 0.53
729_R 755_N 1.177 0.52
610_G 626_I 1.176 0.52
150_K 169_S 1.17 0.52
204_K 207_P 1.169 0.52
239_N 264_M 1.168 0.52
516_Y 556_N 1.163 0.51
431_H 561_G 1.159 0.51
705_Y 710_N 1.158 0.51
69_F 638_S 1.156 0.50
168_G 184_G 1.154 0.50
157_R 161_R 1.152 0.50
541_F 548_G 1.15 0.50
75_I 82_L 1.146 0.49
548_G 580_G 1.146 0.49
555_A 580_G 1.144 0.49
326_R 362_G 1.143 0.49
334_V 542_R 1.139 0.49
153_L 166_D 1.139 0.49
289_L 313_F 1.138 0.49
243_F 546_Y 1.137 0.49
508_L 562_V 1.137 0.49
253_P 336_D 1.137 0.49
250_N 253_P 1.135 0.48
91_Q 706_D 1.135 0.48
527_N 756_I 1.13 0.48
248_Y 256_D 1.129 0.48
580_G 609_A 1.126 0.48
722_S 759_R 1.123 0.47
686_G 702_A 1.123 0.47
642_I 654_L 1.118 0.47
258_T 277_R 1.115 0.47
173_C 180_W 1.113 0.46
129_N 132_D 1.111 0.46
563_T 578_S 1.109 0.46
414_A 428_T 1.106 0.46
292_L 343_F 1.104 0.45
82_L 412_G 1.099 0.45
647_D 650_R 1.097 0.45
56_A 73_V 1.097 0.45
771_E 781_Q 1.096 0.45
735_K 751_A 1.096 0.45
530_S 627_Q 1.095 0.45
694_A 697_W 1.093 0.44
519_Y 589_R 1.092 0.44
227_G 248_Y 1.092 0.44
443_N 448_N 1.09 0.44
553_A 588_S 1.089 0.44
319_G 533_L 1.089 0.44
699_I 752_I 1.089 0.44
227_G 725_C 1.088 0.44
329_V 357_Q 1.088 0.44
310_R 355_A 1.086 0.44
138_G 154_M 1.083 0.43
449_T 487_V 1.083 0.43
252_A 507_T 1.082 0.43
450_E 513_Q 1.08 0.43
627_Q 657_R 1.08 0.43
226_S 252_A 1.078 0.43
541_F 580_G 1.078 0.43
52_V 294_S 1.078 0.43
508_L 638_S 1.077 0.43
372_V 570_A 1.076 0.43
460_Q 526_Y 1.071 0.42
266_R 710_N 1.069 0.42
170_F 203_F 1.068 0.42
770_Q 774_R 1.068 0.42
311_W 335_S 1.064 0.42
720_Q 729_R 1.064 0.42
84_A 110_V 1.064 0.42
483_P 506_Q 1.064 0.42
219_P 227_G 1.063 0.42
683_S 762_S 1.061 0.41
334_V 340_F 1.061 0.41
526_Y 551_R 1.059 0.41
563_T 573_E 1.059 0.41
766_G 769_T 1.059 0.41
217_Q 225_R 1.058 0.41
335_S 339_Y 1.057 0.41
56_A 69_F 1.056 0.41
271_M 343_F 1.055 0.41
287_M 728_I 1.054 0.41
248_Y 378_Q 1.054 0.41
658_Y 683_S 1.053 0.41
77_Q 507_T 1.052 0.41
297_V 693_I 1.051 0.41
540_L 609_A 1.051 0.41
358_K 373_S 1.051 0.41
363_Y 726_Y 1.05 0.40
175_P 178_D 1.049 0.40
578_S 611_D 1.049 0.40
511_R 565_R 1.049 0.40
509_E 565_R 1.048 0.40
727_A 757_E 1.047 0.40
65_D 689_A 1.047 0.40
240_Y 265_H 1.044 0.40
250_N 507_T 1.044 0.40
370_A 394_L 1.043 0.40
729_R 757_E 1.042 0.40
205_V 728_I 1.042 0.40
54_I 485_F 1.041 0.40
280_S 285_G 1.04 0.40
506_Q 564_S 1.039 0.39
148_R 171_T 1.036 0.39
568_D 574_R 1.035 0.39
533_L 542_R 1.034 0.39
771_E 782_N 1.033 0.39
143_V 203_F 1.033 0.39
706_D 759_R 1.033 0.39
228_F 758_L 1.032 0.39
196_A 218_L 1.032 0.39
187_I 706_D 1.03 0.39
509_E 563_T 1.03 0.39
179_T 726_Y 1.028 0.38
772_M 776_N 1.028 0.38
560_T 583_Y 1.027 0.38
65_D 182_V 1.026 0.38
168_G 614_W 1.026 0.38
52_V 104_V 1.024 0.38
767_L 771_E 1.023 0.38
669_P 674_T 1.023 0.38
257_A 354_Y 1.021 0.38
625_G 639_N 1.021 0.38
218_L 254_N 1.021 0.38
158_G 162_Y 1.019 0.38
508_L 579_V 1.017 0.37
148_R 178_D 1.016 0.37
491_M 511_R 1.016 0.37
243_F 373_S 1.016 0.37
248_Y 257_A 1.015 0.37
167_N 259_I 1.015 0.37
557_Q 584_Y 1.014 0.37
339_Y 380_F 1.013 0.37
321_M 327_F 1.012 0.37
317_H 329_V 1.011 0.37
241_F 265_H 1.008 0.37
227_G 258_T 1.008 0.37
140_Y 169_S 1.007 0.37
74_D 83_Q 1.005 0.36
418_V 426_E 1.005 0.36
171_T 707_T 1.004 0.36
122_P 440_L 1.004 0.36
53_T 76_M 1.002 0.36
488_D 718_G 1.001 0.36
160_N 192_E 1 0.36
208_V 339_Y 1 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r19A20.182499.20.924Contact Map0.798
3my2A10.182497.80.952Contact Map0.788
4fqeA10.239858.40.978Contact Map0.51
2wjrA10.2513170.984Contact Map0.755
3qraA10.192612.60.985Contact Map0.384
2vdaB10.03068.60.986Contact Map
1ormA10.16338.10.986Contact Map0.492
4c2mC20.104660.987Contact Map0.532
4e1tA10.18755.90.987Contact Map0.18
3lw5I10.03834.80.987Contact Map0.013
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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