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THIP - Thiamine transport system permease protein ThiP
UniProt: P31549 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11573
Length: 536 (505)
Sequences: 1982
Seq/Len: 3.92
THIP
Paralog alert: 0.41 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: THIP YNJC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
439_C 449_R 5.024 1.00
175_Q 441_S 4.519 1.00
173_A 183_F 3.992 1.00
313_G 318_L 3.649 1.00
69_L 147_V 3.234 1.00
176_L 442_L 3.178 1.00
67_A 200_A 2.885 1.00
448_S 451_K 2.82 1.00
74_A 154_A 2.805 1.00
181_W 185_R 2.722 1.00
65_L 139_L 2.653 1.00
178_M 444_I 2.6 1.00
427_P 461_P 2.565 1.00
65_L 143_L 2.513 1.00
182_H 186_F 2.389 1.00
57_R 61_W 2.388 1.00
343_V 466_L 2.36 1.00
154_A 158_L 2.308 1.00
83_R 170_R 2.21 1.00
444_I 448_S 2.135 1.00
332_W 336_R 2.134 1.00
448_S 452_V 2.12 1.00
211_F 231_Y 2.072 1.00
334_S 474_I 2.036 1.00
179_R 182_H 2.028 1.00
171_Q 437_M 2.013 1.00
445_E 448_S 1.979 1.00
177_G 443_G 1.974 1.00
91_A 95_L 1.965 1.00
431_I 458_L 1.956 1.00
444_I 452_V 1.954 1.00
154_A 199_V 1.929 1.00
186_F 452_V 1.912 1.00
349_T 420_A 1.883 1.00
170_R 188_E 1.856 1.00
61_W 139_L 1.848 1.00
439_C 444_I 1.813 1.00
59_S 208_F 1.775 0.99
173_A 187_V 1.772 0.99
192_L 195_Q 1.765 0.99
180_S 183_F 1.743 0.99
75_I 158_L 1.733 0.99
172_L 438_L 1.731 0.99
63_A 204_F 1.726 0.99
344_L 413_A 1.72 0.99
55_V 229_A 1.717 0.99
446_G 449_R 1.695 0.99
342_G 466_L 1.642 0.99
158_L 196_I 1.635 0.99
334_S 338_A 1.627 0.99
93_L 155_S 1.606 0.99
337_I 409_I 1.588 0.98
174_A 183_F 1.564 0.98
154_A 203_I 1.558 0.98
69_L 73_P 1.547 0.98
185_R 189_W 1.541 0.98
74_A 158_L 1.541 0.98
353_L 428_M 1.531 0.98
146_H 210_S 1.53 0.98
480_V 490_T 1.527 0.98
111_I 145_A 1.521 0.98
75_I 192_L 1.52 0.98
230_I 246_L 1.519 0.98
72_I 76_F 1.506 0.98
135_S 138_G 1.501 0.97
143_L 147_V 1.491 0.97
435_Y 457_A 1.489 0.97
340_A 409_I 1.487 0.97
449_R 453_V 1.48 0.97
208_F 250_Q 1.471 0.97
358_E 436_S 1.467 0.97
284_R 288_R 1.46 0.97
62_Q 142_I 1.45 0.97
503_R 506_D 1.449 0.97
139_L 143_L 1.449 0.97
225_T 228_L 1.446 0.97
71_V 200_A 1.436 0.96
447_W 451_K 1.426 0.96
62_Q 66_S 1.412 0.96
284_R 290_C 1.4 0.96
174_A 440_Q 1.395 0.96
412_N 480_V 1.387 0.95
439_C 453_V 1.382 0.95
423_V 465_A 1.367 0.95
350_M 462_L 1.366 0.95
182_H 185_R 1.363 0.95
170_R 183_F 1.359 0.95
338_A 342_G 1.359 0.95
80_A 290_C 1.358 0.95
372_E 422_K 1.347 0.94
158_L 162_L 1.346 0.94
476_D 480_V 1.345 0.94
239_D 242_R 1.343 0.94
85_R 89_R 1.34 0.94
110_G 218_G 1.333 0.94
70_S 203_I 1.332 0.94
328_W 332_W 1.33 0.94
58_F 223_A 1.32 0.94
148_F 301_L 1.316 0.93
62_Q 225_T 1.314 0.93
412_N 473_S 1.313 0.93
408_V 412_N 1.302 0.93
64_F 516_L 1.28 0.92
75_I 196_I 1.276 0.92
226_I 246_L 1.276 0.92
339_L 343_V 1.272 0.92
436_S 454_E 1.265 0.92
338_A 474_I 1.263 0.92
38_A 43_W 1.259 0.91
162_L 382_P 1.256 0.91
183_F 187_V 1.256 0.91
495_L 514_L 1.251 0.91
209_A 479_V 1.243 0.91
81_L 155_S 1.241 0.91
28_L 32_L 1.237 0.90
476_D 490_T 1.235 0.90
58_F 228_L 1.235 0.90
195_Q 483_F 1.229 0.90
206_L 209_A 1.227 0.90
74_A 155_S 1.226 0.90
186_F 439_C 1.22 0.90
178_M 186_F 1.214 0.89
65_L 147_V 1.203 0.89
162_L 192_L 1.203 0.89
365_M 368_G 1.198 0.88
250_Q 382_P 1.192 0.88
79_R 162_L 1.187 0.88
93_L 159_L 1.186 0.88
477_F 490_T 1.182 0.87
85_R 282_D 1.18 0.87
334_S 473_S 1.18 0.87
105_L 210_S 1.179 0.87
484_G 493_F 1.175 0.87
517_L 524_V 1.174 0.87
150_N 207_C 1.159 0.86
54_H 57_R 1.153 0.86
224_T 229_A 1.153 0.86
477_F 496_Y 1.153 0.86
343_V 347_V 1.152 0.86
404_A 407_I 1.144 0.85
210_S 383_G 1.143 0.85
138_G 176_L 1.138 0.85
182_H 448_S 1.132 0.84
387_A 478_G 1.13 0.84
225_T 491_L 1.127 0.84
62_Q 139_L 1.124 0.84
111_I 477_F 1.122 0.84
192_L 196_I 1.119 0.83
139_L 223_A 1.119 0.83
187_V 453_V 1.119 0.83
420_A 469_A 1.118 0.83
29_A 393_L 1.118 0.83
251_M 254_C 1.118 0.83
334_S 470_C 1.118 0.83
83_R 188_E 1.116 0.83
142_I 218_G 1.113 0.83
383_G 415_M 1.112 0.83
108_V 389_G 1.112 0.83
108_V 212_A 1.111 0.83
31_F 35_W 1.109 0.83
297_L 301_L 1.109 0.83
220_G 309_V 1.106 0.82
59_S 227_E 1.103 0.82
136_P 141_G 1.102 0.82
30_A 35_W 1.098 0.82
334_S 480_V 1.096 0.82
305_P 476_D 1.096 0.82
174_A 180_S 1.095 0.81
145_A 213_T 1.094 0.81
212_A 383_G 1.083 0.80
482_L 495_L 1.078 0.80
299_L 304_P 1.07 0.79
336_R 339_L 1.067 0.79
70_S 147_V 1.067 0.79
225_T 490_T 1.067 0.79
227_E 382_P 1.066 0.79
509_V 512_L 1.065 0.79
206_L 472_L 1.065 0.79
199_V 480_V 1.061 0.79
172_L 353_L 1.058 0.78
141_G 334_S 1.057 0.78
490_T 496_Y 1.055 0.78
121_L 125_C 1.051 0.78
403_S 407_I 1.05 0.78
171_Q 230_I 1.048 0.77
434_R 437_M 1.046 0.77
391_F 483_F 1.045 0.77
386_L 495_L 1.044 0.77
179_R 426_N 1.044 0.77
151_L 155_S 1.043 0.77
53_W 57_R 1.039 0.77
36_W 40_Q 1.039 0.77
110_G 308_A 1.038 0.76
158_L 192_L 1.036 0.76
349_T 421_L 1.035 0.76
57_R 68_L 1.035 0.76
116_G 219_G 1.035 0.76
293_V 297_L 1.031 0.76
169_Q 191_W 1.03 0.76
62_Q 146_H 1.025 0.75
435_Y 438_L 1.024 0.75
66_S 139_L 1.021 0.75
484_G 489_R 1.019 0.75
76_F 293_V 1.018 0.74
105_L 475_G 1.017 0.74
122_A 125_C 1.017 0.74
33_A 37_N 1.016 0.74
99_T 184_F 1.016 0.74
108_V 247_A 1.013 0.74
299_L 303_L 1.011 0.74
408_V 479_V 1.007 0.73
104_V 209_A 1.006 0.73
212_A 416_A 1.001 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2onkC40.49441000.689Contact Map0.707
3d31C20.49631000.701Contact Map0.659
3rlfF10.50191000.721Contact Map0.624
3rlfG10.49071000.731Contact Map0.736
3tuiA40.391899.90.788Contact Map0.675
2l2tA20.08212.40.983Contact Map0.294
2k9pA10.08772.30.983Contact Map0.181
1iijA10.065320.984Contact Map0.816
2kluA10.074620.984Contact Map0.194
1s5rA10.01491.90.984Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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