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OPENSEQ.org
YIEL - Uncharacterized protein YieL
UniProt: P31471 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11729
Length: 389 (356)
Sequences: 452
Seq/Len: 1.27
YIEL
Paralog alert: 0.56 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: FES YIEL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
261_S 266_V 3.981 1.00
269_D 272_G 2.614 1.00
335_V 379_A 2.585 1.00
289_G 299_L 2.419 0.99
172_E 210_K 2.419 0.99
267_R 272_G 2.353 0.99
43_V 128_V 2.293 0.99
217_P 256_I 2.039 0.98
162_W 201_D 1.949 0.97
259_L 263_R 1.876 0.95
300_A 383_F 1.842 0.95
348_A 365_E 1.834 0.95
362_D 386_K 1.814 0.94
179_F 276_A 1.808 0.94
138_V 202_N 1.633 0.89
138_V 205_A 1.614 0.88
162_W 204_L 1.612 0.88
200_M 384_V 1.584 0.87
42_Q 52_R 1.583 0.87
173_P 266_V 1.577 0.87
217_P 340_D 1.564 0.86
183_F 305_V 1.56 0.86
355_E 361_F 1.54 0.85
302_F 383_F 1.534 0.84
207_G 210_K 1.534 0.84
161_V 215_V 1.53 0.84
338_D 365_E 1.514 0.83
50_T 87_R 1.514 0.83
305_V 340_D 1.514 0.83
60_N 389_K 1.508 0.83
303_S 376_W 1.493 0.82
190_A 278_L 1.49 0.82
167_Y 265_N 1.488 0.82
153_L 157_R 1.481 0.82
62_S 75_P 1.457 0.80
202_N 205_A 1.435 0.79
98_Y 109_D 1.434 0.79
53_Y 102_V 1.428 0.78
199_I 202_N 1.427 0.78
174_L 266_V 1.409 0.77
353_E 357_K 1.405 0.77
76_M 86_W 1.403 0.76
98_Y 380_Y 1.398 0.76
44_N 50_T 1.388 0.75
100_F 166_G 1.386 0.75
178_Y 261_S 1.369 0.74
150_S 153_L 1.365 0.74
301_T 334_V 1.362 0.73
63_V 291_N 1.358 0.73
270_A 297_G 1.356 0.73
151_N 154_Q 1.348 0.72
141_G 202_N 1.337 0.71
203_L 387_L 1.336 0.71
279_S 371_H 1.33 0.71
161_V 213_L 1.328 0.71
182_G 296_F 1.315 0.70
178_Y 269_D 1.313 0.69
278_L 377_R 1.308 0.69
80_E 270_A 1.307 0.69
150_S 255_D 1.301 0.68
304_G 347_I 1.293 0.68
141_G 201_D 1.289 0.67
181_H 278_L 1.286 0.67
271_D 330_R 1.284 0.67
174_L 213_L 1.276 0.66
54_F 81_A 1.275 0.66
179_F 196_I 1.273 0.66
278_L 376_W 1.272 0.66
109_D 124_S 1.267 0.65
351_K 361_F 1.266 0.65
194_G 373_M 1.263 0.65
49_V 126_I 1.259 0.65
159_M 256_I 1.258 0.65
351_K 355_E 1.255 0.64
380_Y 384_V 1.25 0.64
375_V 379_A 1.249 0.64
178_Y 213_L 1.245 0.63
109_D 211_P 1.221 0.61
63_V 86_W 1.216 0.61
371_H 376_W 1.212 0.60
262_K 358_K 1.21 0.60
130_G 138_V 1.202 0.59
334_V 350_L 1.202 0.59
61_V 387_L 1.202 0.59
129_P 258_P 1.194 0.59
178_Y 273_R 1.191 0.58
96_Y 185_D 1.191 0.58
174_L 178_Y 1.188 0.58
98_Y 124_S 1.181 0.57
256_I 290_M 1.179 0.57
184_G 278_L 1.177 0.57
179_F 380_Y 1.174 0.57
139_A 203_L 1.163 0.56
138_V 201_D 1.163 0.56
351_K 363_Y 1.157 0.55
141_G 164_P 1.154 0.55
63_V 134_D 1.147 0.54
162_W 333_T 1.144 0.54
52_R 85_S 1.144 0.54
35_P 38_Q 1.143 0.54
98_Y 112_T 1.143 0.54
215_V 260_I 1.142 0.54
292_H 295_S 1.141 0.53
283_Y 340_D 1.137 0.53
163_T 166_G 1.135 0.53
34_I 37_K 1.133 0.53
372_E 378_P 1.131 0.52
152_A 255_D 1.131 0.52
254_N 258_P 1.128 0.52
368_G 375_V 1.127 0.52
179_F 190_A 1.121 0.52
161_V 246_K 1.121 0.52
276_A 300_A 1.119 0.51
63_V 88_T 1.117 0.51
173_P 261_S 1.116 0.51
334_V 361_F 1.111 0.51
66_G 103_D 1.107 0.50
370_N 375_V 1.104 0.50
366_Y 375_V 1.1 0.49
109_D 282_G 1.095 0.49
67_V 76_M 1.09 0.48
352_T 356_Q 1.09 0.48
279_S 282_G 1.084 0.48
178_Y 266_V 1.079 0.47
261_S 267_R 1.076 0.47
255_D 284_Q 1.075 0.47
303_S 377_R 1.074 0.47
174_L 265_N 1.073 0.47
179_F 216_I 1.073 0.47
203_L 381_A 1.072 0.47
173_P 263_R 1.072 0.47
260_I 266_V 1.072 0.47
50_T 297_G 1.072 0.47
200_M 275_L 1.071 0.47
33_T 37_K 1.069 0.46
148_Y 255_D 1.067 0.46
136_R 206_E 1.064 0.46
109_D 112_T 1.063 0.46
190_A 276_A 1.06 0.45
152_A 250_R 1.057 0.45
262_K 271_D 1.057 0.45
209_I 373_M 1.055 0.45
69_V 73_I 1.053 0.45
275_L 285_A 1.052 0.45
121_V 124_S 1.05 0.45
315_V 319_L 1.049 0.44
363_Y 376_W 1.047 0.44
306_T 350_L 1.045 0.44
260_I 289_G 1.045 0.44
203_L 333_T 1.044 0.44
250_R 254_N 1.043 0.44
307_T 340_D 1.041 0.44
177_L 276_A 1.04 0.44
286_L 370_N 1.034 0.43
276_A 383_F 1.033 0.43
276_A 302_F 1.029 0.42
60_N 75_P 1.025 0.42
327_Q 356_Q 1.024 0.42
33_T 39_Y 1.024 0.42
41_T 157_R 1.023 0.42
181_H 184_G 1.023 0.42
63_V 263_R 1.022 0.42
376_W 383_F 1.018 0.41
181_H 383_F 1.017 0.41
43_V 196_I 1.016 0.41
126_I 206_E 1.015 0.41
140_H 203_L 1.015 0.41
164_P 201_D 1.012 0.41
161_V 260_I 1.011 0.41
157_R 282_G 1.008 0.40
248_A 284_Q 1.007 0.40
56_P 377_R 1.006 0.40
177_L 387_L 1.005 0.40
363_Y 377_R 1.005 0.40
50_T 83_V 1.004 0.40
57_G 323_A 1.004 0.40
53_Y 360_N 1.002 0.40
148_Y 212_M 1.001 0.40
283_Y 304_G 1 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c8dA40.88431000.54Contact Map0.504
1jjfA10.65041000.682Contact Map0.587
1gklA20.6711000.724Contact Map0.489
4folA40.62721000.726Contact Map0.501
3gffA20.62721000.727Contact Map0.541
3ls2A40.6351000.737Contact Map0.578
2uz0A40.58611000.742Contact Map0.61
2gzsA10.62211000.749Contact Map0.434
4b6gA20.6531000.752Contact Map0.559
3i6yA20.64011000.754Contact Map0.532
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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