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OPENSEQ.org
DGOK - 2-dehydro-3-deoxygalactonokinase
UniProt: P31459 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11717
Length: 292 (290)
Sequences: 327
Seq/Len: 1.13
DGOK
Paralog alert: 0.19 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
166_L 171_S 5.3 1.00
105_L 152_I 3.597 1.00
63_M 67_V 2.669 1.00
188_T 261_Q 2.569 1.00
81_V 105_L 2.485 0.99
137_M 145_V 1.973 0.96
92_L 102_I 1.789 0.92
183_S 220_Q 1.713 0.90
142_C 233_E 1.697 0.89
35_V 69_S 1.69 0.89
136_V 223_E 1.632 0.87
11_G 16_R 1.625 0.86
78_Y 226_S 1.57 0.84
263_F 268_C 1.537 0.82
232_A 236_S 1.519 0.81
18_W 209_A 1.512 0.81
68_G 101_I 1.493 0.79
17_A 54_W 1.487 0.79
78_Y 140_T 1.475 0.78
115_V 212_V 1.462 0.77
6_I 54_W 1.461 0.77
191_L 262_A 1.447 0.76
71_V 175_A 1.438 0.76
29_R 53_D 1.429 0.75
89_G 286_I 1.422 0.75
126_A 147_A 1.416 0.74
102_I 286_I 1.36 0.70
81_V 281_A 1.337 0.68
158_V 233_E 1.335 0.68
167_L 171_S 1.326 0.67
119_E 208_R 1.318 0.66
119_E 143_K 1.314 0.66
143_K 205_F 1.288 0.64
105_L 234_V 1.282 0.63
143_K 208_R 1.279 0.63
15_L 50_V 1.276 0.63
140_T 166_L 1.274 0.62
8_I 63_M 1.252 0.61
7_A 20_Y 1.251 0.60
163_L 204_L 1.24 0.59
188_T 192_E 1.235 0.59
140_T 171_S 1.227 0.58
122_Q 226_S 1.223 0.58
10_W 122_Q 1.219 0.57
205_F 226_S 1.217 0.57
166_L 170_H 1.214 0.57
35_V 107_V 1.213 0.57
8_I 17_A 1.211 0.57
9_D 12_S 1.209 0.56
187_F 226_S 1.206 0.56
160_T 231_G 1.204 0.56
69_S 177_L 1.203 0.56
192_E 247_I 1.199 0.56
140_T 226_S 1.198 0.55
76_A 101_I 1.195 0.55
195_L 266_M 1.193 0.55
123_L 135_Y 1.191 0.55
136_V 221_V 1.183 0.54
123_L 145_V 1.18 0.54
223_E 258_R 1.179 0.54
10_W 78_Y 1.179 0.54
22_G 26_L 1.174 0.53
71_V 76_A 1.173 0.53
177_L 211_H 1.173 0.53
68_G 76_A 1.173 0.53
172_L 212_V 1.169 0.53
163_L 270_V 1.169 0.53
184_A 257_A 1.169 0.53
13_T 83_A 1.164 0.52
160_T 229_L 1.162 0.52
68_G 73_W 1.162 0.52
251_A 256_T 1.159 0.52
117_R 208_R 1.154 0.51
68_G 71_V 1.143 0.50
159_M 233_E 1.135 0.49
78_Y 143_K 1.12 0.48
249_L 256_T 1.117 0.48
61_V 228_L 1.115 0.48
141_H 205_F 1.114 0.47
18_W 103_P 1.107 0.47
117_R 143_K 1.106 0.47
190_G 224_F 1.097 0.46
117_R 141_H 1.095 0.46
173_I 225_L 1.092 0.45
176_G 211_H 1.092 0.45
34_G 208_R 1.091 0.45
67_V 101_I 1.091 0.45
79_L 83_A 1.09 0.45
70_N 75_V 1.089 0.45
164_H 226_S 1.088 0.45
11_G 117_R 1.082 0.44
117_R 205_F 1.08 0.44
126_A 248_T 1.078 0.44
78_Y 122_Q 1.077 0.44
157_T 205_F 1.076 0.44
143_K 226_S 1.075 0.44
64_A 121_T 1.075 0.44
137_M 279_F 1.074 0.44
61_V 95_V 1.073 0.44
12_S 16_R 1.072 0.43
260_Q 264_Q 1.072 0.43
69_S 102_I 1.07 0.43
43_P 73_W 1.069 0.43
231_G 262_A 1.068 0.43
78_Y 164_H 1.068 0.43
88_I 105_L 1.065 0.43
11_G 122_Q 1.061 0.42
80_S 83_A 1.06 0.42
64_A 275_G 1.06 0.42
16_R 119_E 1.056 0.42
148_D 153_N 1.053 0.42
14_N 113_H 1.05 0.41
119_E 205_F 1.048 0.41
9_D 16_R 1.044 0.41
16_R 34_G 1.044 0.41
128_A 167_L 1.041 0.41
59_T 191_L 1.041 0.41
10_W 226_S 1.041 0.41
34_G 66_M 1.04 0.40
215_T 286_I 1.039 0.40
216_L 250_V 1.035 0.40
124_I 145_V 1.034 0.40
119_E 141_H 1.032 0.40
34_G 119_E 1.032 0.40
36_T 172_L 1.032 0.40
68_G 226_S 1.029 0.39
140_T 143_K 1.028 0.39
96_G 152_I 1.028 0.39
122_Q 155_F 1.027 0.39
62_V 286_I 1.026 0.39
257_A 261_Q 1.026 0.39
6_I 67_V 1.025 0.39
13_T 212_V 1.025 0.39
280_Q 284_R 1.021 0.39
38_L 54_W 1.02 0.39
71_V 101_I 1.02 0.39
261_Q 264_Q 1.017 0.38
187_F 191_L 1.014 0.38
34_G 117_R 1.013 0.38
54_W 67_V 1.011 0.38
162_E 205_F 1.011 0.38
149_S 185_D 1.01 0.38
10_W 16_R 1.01 0.38
13_T 217_P 1.008 0.38
168_L 174_G 1.007 0.37
101_I 275_G 1.002 0.37
187_F 229_L 1.001 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nuwA411000.014Contact Map0.4
3t69A211000.022Contact Map0.43
1huxA20.8185940.938Contact Map0.215
4ehuA20.815193.90.938Contact Map0.193
3bexA60.815191.70.942Contact Map0.151
2f9wA20.8288900.945Contact Map0.13
3djcA120.828888.70.946Contact Map0.144
2h3gX10.845988.30.946Contact Map0.145
2qm1A40.955576.90.953Contact Map0.169
3h1qA20.804875.80.953Contact Map0.176
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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