| UniProt: | P31142 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11600 | ||
| Length: | 281 (276) | ||
| Sequences: | 2135 | ||
| Seq/Len: | 7.74 |
| THTM
Paralog alert: 0.50 [within 20: 0.02] - ratio of genomes with paralogs |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 7_V | 11_W | 4.693 | 1.00 | |
| 89_H | 117_S | 3.405 | 1.00 | |
| 15_H | 18_D | 2.975 | 1.00 | |
| 125_G | 129_D | 2.756 | 1.00 | |
| 214_K | 218_E | 2.748 | 1.00 | |
| 80_R | 143_G | 2.672 | 1.00 | |
| 12_L | 23_I | 2.599 | 1.00 | |
| 45_G | 135_E | 2.584 | 1.00 | |
| 45_G | 127_Q | 2.534 | 1.00 | |
| 12_L | 119_L | 2.499 | 1.00 | |
| 156_K | 159_D | 2.402 | 1.00 | |
| 178_A | 183_E | 2.399 | 1.00 | |
| 177_A | 181_N | 2.381 | 1.00 | |
| 13_A | 131_L | 2.367 | 1.00 | |
| 264_G | 268_E | 2.302 | 1.00 | |
| 75_F | 79_M | 2.3 | 1.00 | |
| 71_R | 74_T | 2.269 | 1.00 | |
| 177_A | 201_N | 2.249 | 1.00 | |
| 179_R | 243_T | 2.235 | 1.00 | |
| 42_Y | 46_H | 2.234 | 1.00 | |
| 118_I | 249_L | 2.228 | 1.00 | |
| 9_A | 129_D | 2.177 | 1.00 | |
| 11_W | 15_H | 2.142 | 1.00 | |
| 244_A | 261_L | 2.132 | 1.00 | |
| 39_A | 43_L | 2.111 | 1.00 | |
| 8_G | 120_G | 2.076 | 1.00 | |
| 123_L | 133_L | 2.058 | 1.00 | |
| 22_Q | 88_K | 2.056 | 1.00 | |
| 9_A | 131_L | 2.01 | 1.00 | |
| 178_A | 184_V | 1.966 | 1.00 | |
| 85_N | 143_G | 1.951 | 1.00 | |
| 9_A | 125_G | 1.932 | 1.00 | |
| 24_I | 51_V | 1.884 | 1.00 | |
| 155_V | 160_V | 1.852 | 1.00 | |
| 113_V | 145_F | 1.818 | 1.00 | |
| 216_T | 220_D | 1.817 | 1.00 | |
| 8_G | 11_W | 1.81 | 1.00 | |
| 214_K | 222_I | 1.79 | 1.00 | |
| 215_T | 218_E | 1.78 | 1.00 | |
| 86_Q | 146_N | 1.76 | 1.00 | |
| 248_L | 261_L | 1.718 | 1.00 | |
| 80_R | 144_E | 1.696 | 1.00 | |
| 24_I | 84_V | 1.686 | 1.00 | |
| 160_V | 235_I | 1.672 | 1.00 | |
| 163_A | 235_I | 1.652 | 1.00 | |
| 7_V | 15_H | 1.586 | 1.00 | |
| 125_G | 212_E | 1.579 | 1.00 | |
| 23_I | 47_I | 1.566 | 1.00 | |
| 84_V | 90_L | 1.555 | 1.00 | |
| 157_V | 272_R | 1.545 | 1.00 | |
| 10_D | 14_E | 1.525 | 1.00 | |
| 155_V | 159_D | 1.523 | 1.00 | |
| 236_V | 251_L | 1.515 | 1.00 | |
| 229_S | 232_K | 1.499 | 0.99 | |
| 76_A | 80_R | 1.481 | 0.99 | |
| 220_D | 224_F | 1.48 | 0.99 | |
| 53_F | 82_L | 1.47 | 0.99 | |
| 76_A | 147_A | 1.442 | 0.99 | |
| 89_H | 115_K | 1.432 | 0.99 | |
| 157_V | 275_L | 1.411 | 0.99 | |
| 102_P | 245_A | 1.402 | 0.99 | |
| 196_I | 199_A | 1.395 | 0.99 | |
| 195_H | 199_A | 1.359 | 0.99 | |
| 75_F | 111_F | 1.344 | 0.99 | |
| 72_P | 76_A | 1.341 | 0.99 | |
| 76_A | 146_N | 1.325 | 0.98 | |
| 69_L | 110_T | 1.324 | 0.98 | |
| 250_A | 254_L | 1.324 | 0.98 | |
| 207_L | 223_F | 1.305 | 0.98 | |
| 192_R | 270_G | 1.303 | 0.98 | |
| 272_R | 275_L | 1.297 | 0.98 | |
| 6_F | 213_L | 1.296 | 0.98 | |
| 75_F | 108_L | 1.294 | 0.98 | |
| 202_V | 222_I | 1.292 | 0.98 | |
| 37_N | 40_Q | 1.289 | 0.98 | |
| 160_V | 169_A | 1.282 | 0.98 | |
| 92_V | 104_A | 1.281 | 0.98 | |
| 209_R | 212_E | 1.276 | 0.98 | |
| 79_M | 108_L | 1.261 | 0.98 | |
| 248_L | 259_V | 1.251 | 0.97 | |
| 218_E | 221_A | 1.241 | 0.97 | |
| 12_L | 91_I | 1.238 | 0.97 | |
| 202_V | 207_L | 1.229 | 0.97 | |
| 69_L | 107_M | 1.222 | 0.97 | |
| 174_A | 247_V | 1.222 | 0.97 | |
| 85_N | 88_K | 1.198 | 0.96 | |
| 170_Q | 232_K | 1.194 | 0.96 | |
| 154_V | 263_D | 1.184 | 0.96 | |
| 161_L | 275_L | 1.181 | 0.96 | |
| 36_R | 41_E | 1.18 | 0.96 | |
| 179_R | 186_E | 1.171 | 0.96 | |
| 202_V | 226_R | 1.17 | 0.96 | |
| 45_G | 133_L | 1.168 | 0.96 | |
| 266_W | 270_G | 1.166 | 0.96 | |
| 7_V | 12_L | 1.152 | 0.95 | |
| 221_A | 225_G | 1.143 | 0.95 | |
| 186_E | 189_P | 1.137 | 0.95 | |
| 155_V | 260_K | 1.136 | 0.95 | |
| 127_Q | 133_L | 1.131 | 0.95 | |
| 157_V | 161_L | 1.122 | 0.94 | |
| 123_L | 127_Q | 1.118 | 0.94 | |
| 251_L | 259_V | 1.114 | 0.94 | |
| 171_I | 237_S | 1.11 | 0.94 | |
| 216_T | 254_L | 1.106 | 0.94 | |
| 169_A | 235_I | 1.1 | 0.94 | |
| 134_E | 137_A | 1.1 | 0.94 | |
| 150_N | 153_A | 1.099 | 0.94 | |
| 29_A | 95_E | 1.099 | 0.94 | |
| 236_V | 259_V | 1.098 | 0.94 | |
| 48_P | 126_W | 1.096 | 0.93 | |
| 233_P | 260_K | 1.091 | 0.93 | |
| 262_Y | 265_A | 1.086 | 0.93 | |
| 249_L | 253_T | 1.079 | 0.93 | |
| 109_R | 252_A | 1.077 | 0.93 | |
| 42_Y | 138_V | 1.076 | 0.93 | |
| 134_E | 138_V | 1.075 | 0.93 | |
| 77_V | 81_E | 1.068 | 0.92 | |
| 155_V | 163_A | 1.066 | 0.92 | |
| 179_R | 239_G | 1.065 | 0.92 | |
| 233_P | 258_N | 1.064 | 0.92 | |
| 22_Q | 140_L | 1.057 | 0.92 | |
| 214_K | 219_L | 1.053 | 0.92 | |
| 105_W | 248_L | 1.052 | 0.91 | |
| 207_L | 246_V | 1.048 | 0.91 | |
| 27_R | 95_E | 1.041 | 0.91 | |
| 47_I | 126_W | 1.036 | 0.91 | |
| 67_H | 179_R | 1.03 | 0.90 | |
| 40_Q | 43_L | 1.025 | 0.90 | |
| 42_Y | 51_V | 1.025 | 0.90 | |
| 179_R | 240_S | 1.023 | 0.90 | |
| 26_A | 92_V | 1.016 | 0.89 | |
| 164_S | 198_G | 1.016 | 0.89 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1urhA | 2 | 0.9964 | 100 | 0.224 | Contact Map | 0.754 |
| 4jgtA | 3 | 0.9893 | 100 | 0.24 | Contact Map | 0.844 |
| 1rhsA | 1 | 0.9893 | 100 | 0.243 | Contact Map | 0.839 |
| 3utnX | 1 | 0.9929 | 100 | 0.248 | Contact Map | 0.749 |
| 3aayA | 2 | 0.9466 | 100 | 0.271 | Contact Map | 0.835 |
| 1e0cA | 1 | 0.9466 | 100 | 0.275 | Contact Map | 0.722 |
| 1uarA | 1 | 0.9573 | 100 | 0.281 | Contact Map | 0.801 |
| 3hzuA | 1 | 0.9431 | 100 | 0.284 | Contact Map | 0.8 |
| 1okgA | 1 | 0.9644 | 100 | 0.297 | Contact Map | 0.682 |
| 2wlrA | 1 | 0.9573 | 100 | 0.322 | Contact Map | 0.735 |
Sequence Conservation (Image Generated using WebLogo v3)