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OPENSEQ.org
YAAJ - Uncharacterized transporter YaaJ
UniProt: P30143 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11555
Length: 476 (466)
Sequences: 1823
Seq/Len: 3.91
YAAJ
Paralog alert: 0.41 [within 20: 0.05] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
92_V 315_A 4.955 1.00
133_M 426_A 3.761 1.00
115_L 437_I 3.64 1.00
219_S 313_A 3.495 1.00
312_T 316_M 3.221 1.00
108_A 434_V 3.187 1.00
227_I 230_L 3.122 1.00
37_F 100_F 3.078 1.00
234_I 238_F 2.863 1.00
118_E 135_R 2.631 1.00
221_V 225_M 2.617 1.00
107_F 438_A 2.599 1.00
235_W 239_E 2.506 1.00
137_L 429_L 2.46 1.00
229_Q 232_H 2.44 1.00
371_A 389_L 2.418 1.00
203_L 207_F 2.376 1.00
150_L 374_N 2.353 1.00
236_S 240_S 2.25 1.00
204_M 362_S 2.228 1.00
223_C 227_I 2.227 1.00
26_C 101_I 2.209 1.00
199_G 202_R 2.209 1.00
145_L 149_F 2.205 1.00
31_R 435_H 2.152 1.00
24_A 428_L 2.136 1.00
92_V 237_I 2.112 1.00
186_A 394_F 2.103 1.00
291_H 440_D 2.01 1.00
6_S 10_S 1.972 1.00
230_L 233_V 1.962 1.00
42_Q 45_K 1.958 1.00
134_A 140_R 1.954 1.00
9_N 414_I 1.931 1.00
233_V 319_L 1.908 1.00
372_E 390_R 1.898 1.00
76_N 306_D 1.882 1.00
183_I 187_V 1.84 1.00
116_Y 433_V 1.838 1.00
133_M 143_G 1.834 1.00
232_H 235_W 1.831 1.00
173_S 353_T 1.824 1.00
140_R 143_G 1.801 0.99
243_G 246_E 1.789 0.99
290_P 294_A 1.78 0.99
213_I 217_L 1.773 0.99
29_T 36_Q 1.755 0.99
188_F 357_I 1.747 0.99
24_A 424_L 1.746 0.99
186_A 398_I 1.73 0.99
21_L 268_M 1.72 0.99
304_F 308_L 1.72 0.99
251_A 254_Y 1.714 0.99
31_R 432_P 1.714 0.99
421_I 425_T 1.708 0.99
5_F 414_I 1.699 0.99
176_F 181_T 1.699 0.99
7_F 11_V 1.693 0.99
64_L 305_I 1.671 0.99
113_A 283_A 1.666 0.99
233_V 316_M 1.666 0.99
406_P 410_Q 1.658 0.99
134_A 377_F 1.655 0.99
190_L 194_T 1.652 0.99
62_Q 201_A 1.644 0.99
190_L 394_F 1.637 0.99
224_V 227_I 1.626 0.99
60_S 287_S 1.623 0.99
282_A 299_Q 1.603 0.99
217_L 221_V 1.602 0.99
330_L 338_K 1.596 0.98
293_A 437_I 1.584 0.98
146_F 419_M 1.574 0.98
27_W 431_S 1.556 0.98
33_G 439_S 1.535 0.98
188_F 361_F 1.522 0.98
179_L 398_I 1.519 0.98
207_F 358_L 1.517 0.98
84_I 92_V 1.517 0.98
318_I 336_I 1.494 0.97
86_A 262_N 1.488 0.97
223_C 316_M 1.477 0.97
177_P 180_V 1.469 0.97
167_A 181_T 1.451 0.97
261_T 265_Q 1.444 0.97
187_V 191_L 1.439 0.96
81_A 318_I 1.424 0.96
207_F 362_S 1.416 0.96
134_A 144_V 1.412 0.96
41_R 45_K 1.411 0.96
154_Y 277_S 1.407 0.96
149_F 418_C 1.406 0.96
387_W 390_R 1.401 0.96
40_I 304_F 1.388 0.95
223_C 230_L 1.386 0.95
5_F 410_Q 1.378 0.95
13_W 417_A 1.374 0.95
249_G 253_G 1.367 0.95
65_C 204_M 1.365 0.95
103_M 304_F 1.354 0.95
163_A 401_T 1.354 0.95
72_V 310_I 1.348 0.94
62_Q 205_Q 1.342 0.94
180_V 184_I 1.332 0.94
42_Q 441_Y 1.329 0.94
391_I 395_A 1.329 0.94
77_L 333_I 1.327 0.94
78_A 332_G 1.324 0.94
84_I 315_A 1.324 0.94
20_L 428_L 1.323 0.94
193_I 368_Y 1.32 0.94
96_W 312_T 1.318 0.94
350_E 354_L 1.316 0.93
100_F 308_L 1.313 0.93
2_P 410_Q 1.306 0.93
375_L 380_L 1.304 0.93
189_T 361_F 1.302 0.93
262_N 265_Q 1.3 0.93
74_S 356_V 1.298 0.93
231_P 235_W 1.291 0.93
179_L 183_I 1.288 0.92
224_V 228_G 1.28 0.92
227_I 231_P 1.278 0.92
202_R 205_Q 1.274 0.92
203_L 365_V 1.274 0.92
42_Q 46_S 1.27 0.92
144_V 378_L 1.266 0.92
132_Y 426_A 1.261 0.91
260_I 264_F 1.261 0.91
220_L 224_V 1.261 0.91
31_R 431_S 1.26 0.91
458_Y 461_I 1.257 0.91
98_A 264_F 1.256 0.91
81_A 336_I 1.254 0.91
237_I 315_A 1.253 0.91
228_G 231_P 1.253 0.91
110_C 299_Q 1.25 0.91
235_W 238_F 1.248 0.91
133_M 142_M 1.238 0.90
61_F 65_C 1.237 0.90
290_P 441_Y 1.236 0.90
435_H 439_S 1.233 0.90
314_S 336_I 1.233 0.90
129_P 132_Y 1.229 0.90
454_D 457_R 1.224 0.90
236_S 319_L 1.215 0.89
64_L 298_V 1.211 0.89
281_A 370_Y 1.208 0.89
411_L 415_I 1.208 0.89
115_L 433_V 1.206 0.89
248_A 251_A 1.192 0.88
144_V 148_V 1.188 0.88
4_F 8_I 1.187 0.88
398_I 402_L 1.18 0.87
8_I 414_I 1.176 0.87
136_G 430_L 1.169 0.87
146_F 279_P 1.169 0.87
120_D 124_Q 1.168 0.87
341_R 349_A 1.164 0.86
432_P 436_T 1.164 0.86
29_T 34_F 1.163 0.86
291_H 444_Q 1.162 0.86
273_A 303_I 1.161 0.86
74_S 166_V 1.16 0.86
315_A 319_L 1.157 0.86
106_S 110_C 1.152 0.86
182_G 401_T 1.151 0.86
3_D 6_S 1.145 0.85
436_T 460_D 1.137 0.85
275_M 420_A 1.137 0.85
4_F 7_F 1.126 0.84
40_I 44_G 1.125 0.84
221_V 344_M 1.12 0.83
80_V 311_C 1.119 0.83
34_F 37_F 1.115 0.83
78_A 81_A 1.112 0.83
299_Q 302_G 1.103 0.82
125_F 286_A 1.101 0.82
59_T 62_Q 1.1 0.82
154_Y 158_F 1.1 0.82
43_F 301_I 1.099 0.82
240_S 244_W 1.099 0.82
177_P 181_T 1.095 0.81
43_F 300_M 1.089 0.81
301_I 305_I 1.086 0.81
437_I 440_D 1.084 0.80
233_V 320_L 1.079 0.80
367_N 416_M 1.075 0.80
20_L 24_A 1.068 0.79
272_E 277_S 1.065 0.79
111_S 296_G 1.065 0.79
245_Q 251_A 1.06 0.78
168_R 334_Q 1.06 0.78
17_M 417_A 1.057 0.78
291_H 441_Y 1.055 0.78
182_G 402_L 1.054 0.78
12_L 16_V 1.053 0.78
166_V 357_I 1.052 0.78
35_V 104_A 1.05 0.77
158_F 275_M 1.049 0.77
36_Q 104_A 1.046 0.77
294_A 450_R 1.044 0.77
71_R 106_S 1.044 0.77
221_V 224_V 1.041 0.77
27_W 31_R 1.039 0.76
395_A 399_G 1.039 0.76
161_V 412_A 1.037 0.76
127_G 283_A 1.037 0.76
22_F 268_M 1.036 0.76
138_G 141_W 1.036 0.76
28_F 108_A 1.035 0.76
364_I 397_V 1.033 0.76
399_G 403_L 1.032 0.76
103_M 308_L 1.031 0.76
433_V 436_T 1.029 0.75
84_I 318_I 1.029 0.75
468_D 471_D 1.025 0.75
70_A 275_M 1.024 0.75
410_Q 414_I 1.022 0.75
165_A 356_V 1.02 0.75
166_V 185_L 1.018 0.74
433_V 437_I 1.016 0.74
161_V 409_W 1.01 0.74
387_W 391_I 1.01 0.74
76_N 270_S 1.01 0.74
275_M 412_A 1.007 0.73
35_V 438_A 1.007 0.73
34_F 100_F 1.002 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l1lA10.83499.80.875Contact Map0.375
3giaA10.806799.80.887Contact Map0.42
4djkA20.829899.60.899Contact Map0.323
2xq2A10.920295.10.963Contact Map0.313
3dh4A40.850894.50.964Contact Map0.316
2a65A10.819383.90.972Contact Map0.405
4m48A10.836181.20.972Contact Map0.455
2jlnA10.783662.30.976Contact Map0.36
4c7rA30.880330.20.98Contact Map0.336
3lw5I10.06340.987Contact Map0.154
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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