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OPENSEQ.org
THIG - Thiazole synthase
UniProt: P30139 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11589
Length: 256 (253)
Sequences: 925
Seq/Len: 3.66
THIG
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
116_A 145_C 4.92 1.00
83_H 122_Q 3.966 1.00
92_N 125_V 3.664 1.00
79_I 118_T 3.613 1.00
14_F 37_L 3.028 1.00
3_R 6_D 3.013 1.00
222_L 225_E 2.99 1.00
117_E 121_Q 2.775 1.00
3_R 8_T 2.704 1.00
9_F 37_L 2.702 1.00
212_D 215_N 2.591 1.00
114_K 117_E 2.414 1.00
7_K 64_T 2.357 1.00
222_L 229_L 2.266 1.00
218_K 229_L 2.233 1.00
109_P 136_L 2.23 1.00
179_V 200_A 2.222 1.00
120_V 143_V 2.208 1.00
130_C 137_C 2.194 1.00
111_E 114_K 2.193 1.00
186_V 235_P 2.178 1.00
15_T 207_I 2.093 1.00
205_T 209_V 2.086 1.00
24_Q 28_E 2.086 1.00
127_L 147_A 2.028 1.00
228_L 232_Q 2.02 1.00
228_L 231_R 1.982 1.00
96_L 116_A 1.962 1.00
10_D 36_Q 1.871 1.00
218_K 222_L 1.866 1.00
158_N 236_G 1.838 0.99
221_R 225_E 1.834 0.99
125_V 146_A 1.769 0.99
164_R 192_Q 1.765 0.99
215_N 229_L 1.761 0.99
113_L 136_L 1.742 0.99
161_L 193_A 1.741 0.99
15_T 35_S 1.738 0.99
189_H 192_Q 1.665 0.99
209_V 236_G 1.65 0.99
171_I 198_A 1.633 0.99
215_N 222_L 1.632 0.99
109_P 130_C 1.63 0.98
121_Q 142_E 1.618 0.98
75_A 118_T 1.594 0.98
152_G 193_A 1.591 0.98
27_V 31_R 1.577 0.98
13_L 224_V 1.568 0.98
141_E 175_T 1.549 0.98
21_A 25_L 1.54 0.98
159_Q 165_A 1.537 0.98
108_D 154_P 1.536 0.98
31_R 63_V 1.529 0.97
110_I 136_L 1.526 0.97
186_V 230_A 1.508 0.97
139_R 142_E 1.493 0.97
136_L 139_R 1.468 0.97
215_N 218_K 1.448 0.96
229_L 232_Q 1.435 0.96
14_F 179_V 1.432 0.96
194_L 228_L 1.422 0.96
75_A 111_E 1.385 0.95
153_A 189_H 1.367 0.94
118_T 122_Q 1.361 0.94
116_A 120_V 1.357 0.94
131_G 166_M 1.355 0.94
244_A 249_T 1.348 0.94
9_F 64_T 1.328 0.93
32_A 218_K 1.328 0.93
59_I 62_G 1.302 0.92
218_K 225_E 1.285 0.91
215_N 232_Q 1.271 0.91
32_A 214_V 1.265 0.91
211_D 234_G 1.265 0.91
127_L 146_A 1.256 0.90
187_P 230_A 1.243 0.90
31_R 62_G 1.214 0.88
79_I 122_Q 1.206 0.88
239_S 243_H 1.189 0.87
83_H 118_T 1.17 0.85
110_I 117_E 1.164 0.85
116_A 143_V 1.144 0.84
108_D 139_R 1.143 0.84
72_A 81_A 1.14 0.83
170_I 174_A 1.096 0.80
120_V 145_C 1.096 0.80
4_I 179_V 1.094 0.80
203_V 207_I 1.093 0.80
48_R 51_N 1.093 0.80
130_C 178_V 1.091 0.79
128_P 145_C 1.087 0.79
75_A 79_I 1.087 0.79
30_I 38_V 1.077 0.78
168_E 172_Q 1.076 0.78
159_Q 238_R 1.075 0.78
100_P 135_V 1.075 0.78
141_E 176_V 1.067 0.77
189_H 238_R 1.062 0.77
5_A 93_W 1.059 0.77
80_F 83_H 1.056 0.76
174_A 178_V 1.056 0.76
141_E 148_V 1.052 0.76
76_E 83_H 1.041 0.75
171_I 178_V 1.025 0.73
37_L 64_T 1.024 0.73
204_N 208_A 1.023 0.73
134_P 170_I 1.022 0.73
114_K 118_T 1.021 0.73
141_E 174_A 1.016 0.72
74_T 77_E 1.006 0.71
5_A 125_V 1.003 0.71
43_K 137_C 1.001 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1wv2A20.98831000.542Contact Map0.657
2htmA40.99221000.543Contact Map0.768
1xm3A411000.625Contact Map0.746
1ep3A10.941499.60.859Contact Map0.445
1ypfA20.945399.40.875Contact Map0.476
2h6rA80.781299.40.875Contact Map0.485
3o07A30.828199.40.879Contact Map0.363
3zwtA10.929799.30.882Contact Map0.459
2e6fA20.937599.30.885Contact Map0.606
4ighA10.945399.30.885Contact Map0.486
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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