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OPENSEQ.org
DCUP - Uroporphyrinogen decarboxylase
UniProt: P29680 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11543
Length: 354 (347)
Sequences: 1932
Seq/Len: 5.57
DCUP
Paralog alert: 0.07 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
8_R 19_D 4.535 1.00
183_D 229_K 3.573 1.00
305_E 347_R 3.404 1.00
11_R 16_Q 3.368 1.00
190_T 233_G 3.363 1.00
45_D 48_S 3.201 1.00
307_E 310_T 3.025 1.00
57_C 130_T 2.94 1.00
105_C 108_D 2.899 1.00
179_H 221_Q 2.852 1.00
197_I 204_V 2.84 1.00
38_A 41_A 2.828 1.00
13_L 266_A 2.82 1.00
179_H 226_Y 2.665 1.00
8_R 20_V 2.638 1.00
65_R 138_E 2.631 1.00
259_M 267_L 2.552 1.00
308_V 341_F 2.519 1.00
277_D 280_R 2.384 1.00
257_E 281_R 2.376 1.00
125_M 195_A 2.339 1.00
9_Y 203_A 2.33 1.00
220_Q 258_A 2.325 1.00
174_D 177_A 2.302 1.00
195_A 198_K 2.288 1.00
309_A 313_A 2.252 1.00
186_A 190_T 2.229 1.00
132_R 202_Q 2.22 1.00
187_K 229_K 2.184 1.00
25_M 341_F 2.164 1.00
228_H 232_D 2.159 1.00
334_P 337_H 2.145 1.00
301_P 340_V 2.128 1.00
310_T 314_G 2.102 1.00
145_S 189_V 2.076 1.00
106_K 110_D 2.027 1.00
339_G 343_E 1.995 1.00
122_G 126_N 1.995 1.00
12_A 287_A 1.939 1.00
340_V 344_A 1.93 1.00
15_R 320_G 1.922 1.00
109_V 177_A 1.899 1.00
309_A 344_A 1.887 1.00
106_K 174_D 1.86 1.00
302_A 306_E 1.857 1.00
25_M 338_A 1.838 1.00
9_Y 246_T 1.823 1.00
308_V 344_A 1.77 1.00
110_D 180_A 1.769 1.00
190_T 229_K 1.754 1.00
179_H 222_F 1.744 1.00
104_T 166_V 1.723 1.00
170_M 177_A 1.696 1.00
274_D 314_G 1.69 1.00
300_P 303_R 1.681 1.00
343_E 347_R 1.663 1.00
301_P 337_H 1.657 1.00
231_V 264_C 1.62 0.99
323_F 345_V 1.618 0.99
7_D 11_R 1.614 0.99
54_E 130_T 1.614 0.99
167_I 178_L 1.608 0.99
305_E 344_A 1.605 0.99
88_G 100_T 1.595 0.99
180_A 184_K 1.578 0.99
194_N 238_N 1.572 0.99
107_A 110_D 1.552 0.99
190_T 230_I 1.551 0.99
21_T 321_H 1.543 0.99
74_L 131_I 1.541 0.99
194_N 233_G 1.54 0.99
11_R 19_D 1.538 0.99
313_A 348_L 1.525 0.99
276_A 314_G 1.521 0.99
337_H 340_V 1.483 0.99
108_D 111_K 1.482 0.99
187_K 190_T 1.459 0.99
54_E 57_C 1.457 0.98
186_A 230_I 1.442 0.98
235_L 265_D 1.427 0.98
52_N 55_L 1.415 0.98
256_L 278_A 1.413 0.98
164_F 209_T 1.407 0.98
156_V 170_M 1.394 0.98
309_A 348_L 1.389 0.98
305_E 340_V 1.383 0.98
220_Q 261_E 1.38 0.98
216_G 220_Q 1.354 0.97
304_I 340_V 1.349 0.97
48_S 52_N 1.345 0.97
302_A 305_E 1.336 0.97
299_A 303_R 1.335 0.97
15_R 287_A 1.322 0.97
263_G 286_V 1.319 0.97
67_Y 339_G 1.319 0.97
298_Y 332_D 1.312 0.97
106_K 177_A 1.309 0.96
90_Y 100_T 1.305 0.96
129_R 199_A 1.304 0.96
261_E 285_K 1.296 0.96
49_L 59_V 1.281 0.96
9_Y 13_L 1.263 0.95
312_L 348_L 1.245 0.95
344_A 347_R 1.243 0.95
183_D 226_Y 1.222 0.94
329_I 333_V 1.213 0.94
344_A 348_L 1.192 0.93
130_T 134_E 1.19 0.93
282_V 288_L 1.187 0.93
198_K 237_E 1.184 0.93
8_R 18_V 1.181 0.93
311_I 323_F 1.179 0.93
57_C 134_E 1.172 0.92
20_V 346_H 1.172 0.92
183_D 187_K 1.169 0.92
340_V 343_E 1.161 0.92
229_K 233_G 1.159 0.92
304_I 337_H 1.158 0.92
61_L 65_R 1.147 0.91
329_I 338_A 1.135 0.91
266_A 322_V 1.135 0.91
330_H 333_V 1.132 0.91
294_P 326_G 1.131 0.91
66_R 339_G 1.13 0.91
277_D 281_R 1.13 0.91
20_V 350_E 1.129 0.91
12_A 18_V 1.126 0.90
126_N 130_T 1.115 0.90
171_M 178_L 1.109 0.89
101_S 111_K 1.107 0.89
106_K 180_A 1.104 0.89
12_A 22_P 1.094 0.89
298_Y 333_V 1.089 0.88
254_Q 273_T 1.088 0.88
13_L 322_V 1.082 0.88
151_L 189_V 1.071 0.87
247_L 264_C 1.066 0.87
247_L 262_T 1.063 0.87
117_P 125_M 1.061 0.86
62_Q 66_R 1.055 0.86
47_M 51_K 1.053 0.86
177_A 180_A 1.052 0.86
206_I 227_M 1.05 0.86
275_I 315_F 1.045 0.85
126_N 129_R 1.044 0.85
287_A 320_G 1.043 0.85
56_A 127_A 1.042 0.85
292_M 323_F 1.04 0.85
76_S 80_T 1.026 0.84
32_Y 67_Y 1.024 0.84
219_Y 227_M 1.022 0.84
217_R 220_Q 1.021 0.84
53_A 126_N 1.019 0.83
336_E 339_G 1.018 0.83
107_A 111_K 1.017 0.83
21_T 312_L 1.016 0.83
197_I 243_V 1.012 0.83
267_L 282_V 1.01 0.83
301_P 305_E 1.008 0.82
186_A 233_G 1.006 0.82
303_R 306_E 1.006 0.82
206_I 230_I 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cyvA10.99441000.101Contact Map0.715
4exqA10.99441000.102Contact Map0.73
1r3sA10.99151000.112Contact Map0.722
2infA40.98021000.115Contact Map0.788
1j93A10.97741000.144Contact Map0.712
2ejaA20.9521000.16Contact Map0.734
4ay7A20.93221000.215Contact Map0.677
1u1jA10.906899.90.68Contact Map0.492
3rpdA20.889899.90.688Contact Map0.532
2nq5A10.909699.90.695Contact Map0.481
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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