May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
RARD - Protein RarD
UniProt: P27844 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11466
Length: 296 (292)
Sequences: 889
Seq/Len: 3.04
RARD
Paralog alert: 0.18 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
121_L 166_L 3.776 1.00
89_L 156_G 3.089 1.00
39_L 91_I 2.68 1.00
41_H 45_W 2.555 1.00
79_S 168_R 2.54 1.00
26_Y 218_A 2.374 1.00
55_S 60_W 2.305 1.00
84_G 186_L 2.231 1.00
85_G 160_S 2.222 1.00
126_R 286_D 2.208 1.00
13_A 233_A 2.181 1.00
98_H 101_E 2.106 1.00
139_G 275_F 2.074 1.00
85_G 89_L 2.054 1.00
255_L 259_T 2.042 1.00
116_L 162_A 2.008 1.00
28_K 261_Y 1.969 1.00
19_I 225_V 1.957 1.00
12_L 232_A 1.947 1.00
19_I 229_C 1.908 0.99
25_A 261_Y 1.88 0.99
100_L 254_F 1.875 0.99
92_W 96_N 1.813 0.99
265_P 270_M 1.794 0.99
50_M 180_L 1.791 0.99
14_L 248_I 1.789 0.99
82_L 116_L 1.77 0.99
234_A 242_L 1.745 0.99
76_L 173_V 1.744 0.99
32_Y 212_L 1.729 0.99
141_L 145_W 1.72 0.99
244_F 280_L 1.705 0.98
99_M 261_Y 1.702 0.98
30_I 215_L 1.678 0.98
168_R 178_G 1.675 0.98
238_R 241_T 1.656 0.98
266_G 269_K 1.653 0.98
144_L 150_L 1.647 0.98
143_Q 272_T 1.638 0.98
159_F 163_F 1.626 0.98
280_L 284_V 1.625 0.98
15_A 229_C 1.617 0.98
23_A 249_G 1.611 0.98
107_F 251_T 1.605 0.97
47_F 187_L 1.595 0.97
99_M 257_A 1.591 0.97
13_A 245_F 1.575 0.97
90_F 253_M 1.569 0.97
92_W 153_I 1.564 0.97
274_A 278_V 1.524 0.96
12_L 229_C 1.504 0.96
13_A 242_L 1.474 0.95
112_V 159_F 1.473 0.95
109_N 249_G 1.439 0.94
64_K 68_Q 1.429 0.94
218_A 221_I 1.417 0.94
93_A 102_A 1.416 0.94
90_F 102_A 1.411 0.94
38_I 95_N 1.408 0.93
198_A 203_S 1.404 0.93
107_F 272_T 1.403 0.93
39_L 88_L 1.384 0.93
256_L 260_F 1.378 0.92
241_T 283_F 1.342 0.91
192_I 196_A 1.333 0.91
174_E 177_T 1.331 0.91
11_L 15_A 1.33 0.91
74_F 78_V 1.322 0.90
100_L 257_A 1.314 0.90
100_L 272_T 1.313 0.90
135_L 278_V 1.312 0.90
139_G 260_F 1.307 0.90
179_M 183_T 1.293 0.89
155_L 159_F 1.293 0.89
237_L 241_T 1.289 0.89
210_M 214_L 1.288 0.89
113_N 239_L 1.287 0.89
246_Q 249_G 1.275 0.88
109_N 246_Q 1.269 0.88
95_N 261_Y 1.261 0.87
214_L 218_A 1.253 0.87
99_M 256_L 1.251 0.87
128_M 282_I 1.242 0.86
50_M 179_M 1.235 0.86
122_G 127_R 1.228 0.85
153_I 157_L 1.226 0.85
206_G 213_N 1.217 0.85
130_W 134_I 1.215 0.84
209_P 212_L 1.207 0.84
163_F 167_V 1.192 0.83
249_G 253_M 1.189 0.83
100_L 265_P 1.188 0.83
102_A 253_M 1.18 0.82
27_F 218_A 1.177 0.82
80_A 124_R 1.171 0.81
90_F 249_G 1.164 0.81
120_F 163_F 1.16 0.81
205_M 213_N 1.158 0.80
77_A 185_W 1.156 0.80
40_T 258_V 1.147 0.79
107_F 168_R 1.133 0.78
44_I 194_L 1.129 0.78
70_P 74_F 1.129 0.78
244_F 283_F 1.121 0.77
37_E 197_I 1.12 0.77
61_S 64_K 1.112 0.77
51_V 180_L 1.111 0.76
138_C 274_A 1.11 0.76
178_G 231_T 1.11 0.76
52_V 55_S 1.105 0.76
28_K 95_N 1.09 0.74
13_A 17_Y 1.09 0.74
76_L 181_I 1.081 0.74
60_W 63_L 1.081 0.74
14_L 18_F 1.077 0.73
267_A 271_V 1.071 0.73
116_L 120_F 1.07 0.73
111_L 140_V 1.057 0.71
48_F 74_F 1.055 0.71
54_M 174_E 1.051 0.71
252_L 256_L 1.051 0.71
109_N 230_F 1.031 0.68
247_Y 280_L 1.029 0.68
62_Y 174_E 1.021 0.67
29_L 215_L 1.019 0.67
139_G 279_A 1.017 0.67
107_F 244_F 1.012 0.66
20_W 223_T 1.011 0.66
135_L 279_A 1.005 0.66
161_F 165_G 1.004 0.65
52_V 56_I 1.001 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i68A20.37597.70.911Contact Map0.023
3b5dA20.358196.90.922Contact Map0.003
3m73A10.918930.90.965Contact Map0.122
2m67A10.23658.40.973Contact Map0.39
1wazA10.14863.40.978Contact Map0.063
4hg6A10.2233.10.978Contact Map0.389
2kv5A10.10812.60.979Contact Map0
4he8L20.34462.40.979Contact Map0.106
4knfA50.20612.20.98Contact Map0.554
2kvoA10.1522.10.98Contact Map0
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0272 seconds.