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OPENSEQ.org
YCFD - 50S ribosomal protein L16 arginine hydroxylase
UniProt: P27431 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11430
Length: 373 (367)
Sequences: 481
Seq/Len: 1.31
YCFD
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
139_R 174_E 4.103 1.00
143_R 188_E 2.495 1.00
121_G 188_E 2.39 0.99
11_D 15_R 2.03 0.98
133_I 197_N 1.972 0.97
27_G 178_I 1.962 0.97
141_R 192_L 1.956 0.97
126_L 186_P 1.904 0.96
118_P 193_E 1.828 0.95
167_A 188_E 1.731 0.93
101_R 105_D 1.72 0.92
93_T 111_L 1.709 0.92
141_R 170_D 1.692 0.91
121_G 143_R 1.657 0.90
25_K 174_E 1.635 0.90
54_V 68_F 1.588 0.88
120_G 123_G 1.577 0.87
31_F 136_G 1.569 0.87
40_L 86_V 1.558 0.86
82_L 195_A 1.538 0.85
204_A 227_Y 1.537 0.85
191_A 195_A 1.533 0.85
343_T 346_N 1.527 0.85
85_A 88_H 1.524 0.85
139_R 193_E 1.51 0.84
21_P 25_K 1.507 0.84
114_S 199_S 1.507 0.84
313_R 338_S 1.506 0.84
82_L 86_V 1.491 0.83
172_E 192_L 1.463 0.81
246_E 312_L 1.46 0.81
112_M 129_Y 1.457 0.81
134_I 178_I 1.456 0.81
7_L 333_L 1.451 0.80
273_S 312_L 1.427 0.79
61_W 79_W 1.425 0.79
268_F 272_I 1.415 0.78
115_F 194_N 1.413 0.78
102_E 116_S 1.413 0.78
77_T 173_L 1.403 0.77
37_P 41_A 1.403 0.77
233_V 246_E 1.401 0.77
42_G 46_E 1.388 0.76
363_L 368_Y 1.374 0.75
136_G 198_Y 1.372 0.75
8_N 11_D 1.372 0.75
174_E 193_E 1.356 0.74
86_V 113_I 1.34 0.73
133_I 181_I 1.314 0.70
41_A 81_L 1.301 0.69
79_W 319_Y 1.289 0.68
50_D 276_R 1.279 0.67
15_R 20_R 1.278 0.67
51_S 66_G 1.278 0.67
110_D 129_Y 1.277 0.67
144_V 181_I 1.277 0.67
284_P 287_P 1.276 0.67
38_D 42_G 1.27 0.67
108_I 158_D 1.268 0.66
214_F 254_M 1.264 0.66
107_R 268_F 1.262 0.66
11_D 59_G 1.259 0.66
121_G 190_Y 1.239 0.64
144_V 185_F 1.238 0.64
112_M 122_V 1.234 0.63
97_M 111_L 1.229 0.63
11_D 14_E 1.226 0.63
233_V 333_L 1.223 0.62
68_F 218_V 1.216 0.62
317_D 324_K 1.214 0.61
293_I 364_V 1.212 0.61
333_L 337_A 1.211 0.61
79_W 110_D 1.21 0.61
129_Y 203_R 1.2 0.60
90_H 277_H 1.194 0.60
54_V 124_P 1.194 0.60
16_H 29_N 1.193 0.59
112_M 199_S 1.189 0.59
191_A 228_Y 1.186 0.59
116_S 197_N 1.186 0.59
303_L 371_F 1.184 0.59
129_Y 140_R 1.176 0.58
64_S 70_S 1.17 0.57
112_M 203_R 1.17 0.57
49_V 252_E 1.164 0.57
63_V 158_D 1.163 0.57
116_S 133_I 1.155 0.56
121_G 195_A 1.154 0.56
145_G 169_I 1.15 0.55
133_I 161_Q 1.147 0.55
89_W 105_D 1.147 0.55
335_A 346_N 1.146 0.55
109_D 140_R 1.143 0.55
297_L 357_L 1.137 0.54
107_R 204_A 1.133 0.54
17_W 43_L 1.133 0.54
293_I 361_A 1.133 0.54
109_D 129_Y 1.132 0.54
110_D 120_G 1.131 0.53
247_M 268_F 1.129 0.53
49_V 292_E 1.12 0.52
16_H 19_K 1.114 0.52
214_F 217_Y 1.109 0.51
149_Q 200_V 1.109 0.51
189_G 199_S 1.107 0.51
165_F 269_G 1.105 0.51
112_M 140_R 1.105 0.51
334_D 338_S 1.105 0.51
6_T 9_W 1.102 0.51
18_Q 42_G 1.1 0.50
78_N 184_G 1.099 0.50
118_P 194_N 1.092 0.50
93_T 163_D 1.092 0.50
23_V 171_E 1.089 0.49
109_D 112_M 1.088 0.49
123_G 189_G 1.087 0.49
86_V 198_Y 1.086 0.49
112_M 189_G 1.084 0.49
110_D 114_S 1.083 0.49
84_Q 112_M 1.083 0.49
31_F 198_Y 1.082 0.49
11_D 20_R 1.078 0.48
268_F 312_L 1.078 0.48
31_F 134_I 1.077 0.48
110_D 189_G 1.076 0.48
114_S 189_G 1.074 0.48
273_S 303_L 1.072 0.48
110_D 199_S 1.072 0.48
123_G 203_R 1.072 0.48
144_V 169_I 1.071 0.47
213_G 224_G 1.071 0.47
110_D 123_G 1.071 0.47
19_K 232_D 1.069 0.47
218_V 260_Q 1.068 0.47
71_Y 75_G 1.067 0.47
16_H 22_V 1.067 0.47
158_D 305_R 1.065 0.47
19_K 24_L 1.064 0.47
144_V 168_I 1.063 0.47
13_L 233_V 1.063 0.47
78_N 98_R 1.062 0.47
114_S 129_Y 1.061 0.46
140_R 203_R 1.058 0.46
45_M 113_I 1.058 0.46
250_L 253_M 1.055 0.46
129_Y 189_G 1.054 0.46
10_P 14_E 1.053 0.46
317_D 330_R 1.05 0.45
27_G 275_S 1.047 0.45
255_L 358_A 1.046 0.45
46_E 106_W 1.046 0.45
119_G 200_V 1.046 0.45
332_A 356_F 1.044 0.45
129_Y 199_S 1.043 0.45
37_P 297_L 1.042 0.45
17_W 21_P 1.041 0.44
113_I 198_Y 1.041 0.44
26_R 331_P 1.037 0.44
84_Q 203_R 1.037 0.44
238_H 258_I 1.036 0.44
126_L 170_D 1.035 0.44
143_R 170_D 1.034 0.44
14_E 25_K 1.033 0.44
292_E 360_L 1.03 0.43
82_L 112_M 1.027 0.43
251_R 261_P 1.026 0.43
20_R 26_R 1.025 0.43
84_Q 110_D 1.024 0.43
52_R 67_P 1.023 0.43
18_Q 114_S 1.021 0.43
110_D 201_G 1.021 0.43
170_D 192_L 1.018 0.42
81_L 204_A 1.016 0.42
121_G 198_Y 1.014 0.42
162_V 197_N 1.013 0.42
247_M 257_L 1.011 0.42
141_R 172_E 1.011 0.42
355_S 366_S 1.01 0.41
85_A 277_H 1.008 0.41
110_D 122_V 1.005 0.41
116_S 140_R 1.004 0.41
202_F 205_P 1.003 0.41
183_P 269_G 1.003 0.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4e4hA40.98931000.493Contact Map0.35
2xdvA10.98121000.534Contact Map0.363
1vrbA40.78021000.553Contact Map0.367
3al5A40.71051000.693Contact Map0.402
3kv5D20.81231000.73Contact Map0.326
4gjzA10.53891000.739Contact Map0.433
3k2oA20.65681000.743Contact Map0.358
3kv4A10.80799.90.76Contact Map0.356
3purA20.801699.90.777Contact Map0.385
3puaA10.809799.90.794Contact Map0.33
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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