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OPENSEQ.org
PLSX - Phosphate acyltransferase
UniProt: P27247 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11437
Length: 356 (332)
Sequences: 1241
Seq/Len: 3.74
PLSX
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_S 46_T 4.779 1.00
327_Q 330_Q 4.011 1.00
66_Q 84_G 3.716 1.00
94_V 99_A 3.18 1.00
287_D 309_N 3.105 1.00
42_S 64_P 2.893 1.00
90_A 102_C 2.864 1.00
30_S 314_A 2.801 1.00
45_I 62_I 2.798 1.00
41_N 64_P 2.746 1.00
230_C 234_T 2.54 1.00
8_L 24_A 2.534 1.00
181_A 215_L 2.503 1.00
189_E 204_K 2.481 1.00
35_T 61_Q 2.468 1.00
37_L 99_A 2.307 1.00
211_Y 214_Y 2.299 1.00
39_V 93_L 2.287 1.00
212_I 225_T 2.279 1.00
41_N 44_A 2.208 1.00
28_L 59_R 2.17 1.00
19_V 22_P 2.154 1.00
200_S 211_Y 2.125 1.00
153_C 161_F 2.04 1.00
165_G 227_V 2.033 1.00
166_S 180_V 1.966 1.00
193_L 196_I 1.945 1.00
92_E 96_E 1.942 1.00
130_L 303_K 1.821 0.99
170_E 176_P 1.799 0.99
298_R 333_A 1.77 0.99
27_A 317_I 1.752 0.99
65_A 89_V 1.748 0.99
219_E 224_K 1.746 0.99
221_L 242_M 1.743 0.99
159_V 202_V 1.703 0.99
103_V 320_A 1.702 0.99
180_V 209_I 1.671 0.99
87_M 111_L 1.658 0.99
142_T 228_L 1.644 0.99
7_A 99_A 1.623 0.99
21_V 25_L 1.623 0.99
39_V 65_A 1.622 0.99
61_Q 98_R 1.606 0.98
84_G 89_V 1.582 0.98
282_S 288_Q 1.571 0.98
215_L 225_T 1.559 0.98
304_S 316_A 1.539 0.98
195_S 199_A 1.538 0.98
159_V 206_I 1.531 0.98
111_L 301_V 1.503 0.97
88_R 118_L 1.502 0.97
26_Q 314_A 1.5 0.97
264_W 268_L 1.497 0.97
70_A 73_A 1.493 0.97
261_K 267_L 1.49 0.97
111_L 303_K 1.482 0.97
321_V 325_Q 1.478 0.97
201_A 205_T 1.464 0.97
126_E 156_T 1.447 0.96
46_T 62_I 1.446 0.96
265_W 275_K 1.443 0.96
212_I 224_K 1.414 0.96
269_L 272_W 1.412 0.96
269_L 276_S 1.411 0.96
171_E 331_R 1.397 0.95
5_T 100_Q 1.389 0.95
6_L 9_D 1.382 0.95
30_S 318_E 1.38 0.95
152_D 193_L 1.376 0.95
5_T 35_T 1.369 0.95
151_V 185_I 1.364 0.94
183_L 238_T 1.363 0.94
179_R 212_I 1.362 0.94
263_S 266_L 1.353 0.94
31_N 318_E 1.345 0.94
93_L 98_R 1.345 0.94
132_T 147_L 1.339 0.94
220_L 238_T 1.328 0.93
200_S 214_Y 1.328 0.93
264_W 267_L 1.324 0.93
16_G 19_V 1.322 0.93
198_D 201_A 1.319 0.93
37_L 63_I 1.306 0.93
27_A 34_L 1.291 0.92
116_K 121_P 1.282 0.92
144_V 147_L 1.278 0.91
37_L 93_L 1.269 0.91
7_A 90_A 1.267 0.91
304_S 313_F 1.258 0.91
136_H 223_G 1.256 0.91
154_D 157_M 1.247 0.90
10_V 45_I 1.245 0.90
24_A 36_L 1.244 0.90
91_L 119_L 1.241 0.90
19_V 309_N 1.239 0.90
119_L 299_G 1.239 0.90
115_A 301_V 1.23 0.89
91_L 114_L 1.226 0.89
67_S 84_G 1.223 0.89
41_N 65_A 1.214 0.88
166_S 170_E 1.21 0.88
113_G 117_L 1.208 0.88
20_T 313_F 1.206 0.88
115_A 119_L 1.203 0.88
327_Q 331_R 1.201 0.88
234_T 237_V 1.197 0.87
134_L 144_V 1.196 0.87
136_H 142_T 1.193 0.87
143_V 173_V 1.193 0.87
169_A 173_V 1.19 0.87
18_S 22_P 1.19 0.87
63_I 98_R 1.183 0.87
155_S 199_A 1.181 0.87
260_K 270_K 1.177 0.86
189_E 200_S 1.177 0.86
159_V 163_I 1.175 0.86
143_V 169_A 1.174 0.86
10_V 38_L 1.168 0.86
308_A 312_A 1.162 0.85
194_D 198_D 1.154 0.85
215_L 228_L 1.151 0.85
159_V 203_L 1.151 0.85
288_Q 311_R 1.148 0.84
31_N 321_V 1.142 0.84
67_S 82_S 1.139 0.84
242_M 245_V 1.138 0.84
112_M 130_L 1.138 0.84
278_T 281_F 1.136 0.84
87_M 303_K 1.136 0.84
13_G 16_G 1.135 0.83
247_R 286_P 1.131 0.83
162_A 203_L 1.122 0.82
39_V 89_V 1.121 0.82
138_Q 179_R 1.114 0.82
177_N 210_N 1.11 0.82
45_I 49_L 1.102 0.81
169_A 227_V 1.102 0.81
18_S 48_L 1.101 0.81
126_E 157_M 1.1 0.81
46_T 57_R 1.1 0.81
44_A 47_P 1.099 0.81
126_E 160_Q 1.094 0.80
260_K 266_L 1.091 0.80
33_Q 325_Q 1.09 0.80
89_V 92_E 1.083 0.79
151_V 234_T 1.083 0.79
89_V 93_L 1.075 0.79
267_L 274_Q 1.071 0.78
241_T 245_V 1.063 0.78
179_R 227_V 1.062 0.77
256_Q 262_R 1.06 0.77
129_A 145_L 1.058 0.77
290_N 304_S 1.058 0.77
7_A 94_V 1.055 0.77
91_L 102_C 1.054 0.77
21_V 49_L 1.049 0.76
291_G 302_I 1.045 0.76
112_M 150_N 1.042 0.76
293_C 323_A 1.041 0.75
122_L 329_P 1.039 0.75
221_L 245_V 1.038 0.75
145_L 165_G 1.037 0.75
183_L 228_L 1.036 0.75
159_V 199_A 1.035 0.75
87_M 107_N 1.032 0.75
19_V 310_Q 1.027 0.74
8_L 36_L 1.024 0.74
92_E 118_L 1.023 0.74
21_V 48_L 1.016 0.73
5_T 37_L 1.016 0.73
155_S 198_D 1.014 0.73
158_L 199_A 1.01 0.72
164_M 332_I 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u7nA20.93541000.392Contact Map0.79
1vi1A20.96351000.404Contact Map0.785
1vmiA10.83151000.614Contact Map0.572
2af4C20.78931000.614Contact Map0.641
1td9A60.77811000.632Contact Map0.661
1r5jA20.79211000.636Contact Map0.668
4e4rA10.77811000.649Contact Map0.619
3uf6A20.71071000.651Contact Map0.577
1ycoA20.70791000.661Contact Map0.481
3lxyA10.79781000.716Contact Map0.455
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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