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OPENSEQ.org
YIDC - Membrane protein insertase YidC
UniProt: P25714 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11197
Length: 548 (540)
Sequences: 887
Seq/Len: 1.64
YIDC
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
407_E 410_A 5.295 1.00
351_V 360_I 3.919 1.00
410_A 414_A 3.532 1.00
386_L 417_V 3.493 1.00
356_F 451_F 3.41 1.00
394_R 398_G 3.003 1.00
64_K 85_P 2.979 1.00
342_K 346_W 2.878 1.00
391_Q 394_R 2.801 1.00
389_K 392_A 2.681 1.00
393_M 404_I 2.662 1.00
64_K 69_D 2.553 1.00
472_G 503_T 2.553 1.00
391_Q 395_E 2.531 1.00
369_M 432_I 2.501 1.00
347_I 360_I 2.444 1.00
343_L 364_I 2.299 1.00
82_A 309_V 2.196 0.99
72_I 151_M 2.138 0.99
347_I 351_V 2.126 0.99
162_T 179_N 2.112 0.99
65_T 167_L 2.089 0.99
392_A 396_R 2.032 0.99
393_M 398_G 1.969 0.98
356_F 452_A 1.93 0.98
470_L 474_T 1.913 0.98
63_V 167_L 1.894 0.97
356_F 360_I 1.893 0.97
467_L 515_L 1.893 0.97
390_I 393_M 1.882 0.97
70_L 82_A 1.88 0.97
469_I 473_V 1.86 0.97
371_P 375_A 1.859 0.97
470_L 518_I 1.83 0.97
402_Q 406_Q 1.823 0.97
77_G 151_M 1.788 0.96
344_L 357_S 1.74 0.95
403_R 407_E 1.729 0.95
471_M 503_T 1.71 0.95
261_A 327_T 1.708 0.95
387_Q 391_Q 1.702 0.94
394_R 404_I 1.695 0.94
356_F 359_I 1.682 0.94
404_I 408_M 1.679 0.94
381_A 384_R 1.667 0.94
398_G 401_K 1.663 0.94
400_D 403_R 1.663 0.94
69_D 83_L 1.654 0.93
70_L 167_L 1.628 0.93
369_M 428_I 1.617 0.92
179_N 302_A 1.612 0.92
66_D 170_G 1.586 0.91
133_V 138_Y 1.585 0.91
296_Q 299_Q 1.575 0.91
455_I 467_L 1.562 0.90
473_V 477_F 1.546 0.90
347_I 364_I 1.546 0.90
503_T 507_L 1.533 0.89
397_L 403_R 1.522 0.89
173_A 320_V 1.51 0.88
365_V 428_I 1.506 0.88
469_I 500_V 1.5 0.88
403_R 406_Q 1.489 0.87
438_Y 442_G 1.484 0.87
141_A 144_Q 1.466 0.86
150_P 164_T 1.455 0.86
359_I 515_L 1.455 0.86
336_I 340_L 1.448 0.85
162_T 181_Q 1.422 0.84
71_T 81_Q 1.422 0.84
363_F 523_V 1.417 0.84
134_E 152_T 1.41 0.83
351_V 356_F 1.405 0.83
177_N 302_A 1.401 0.83
19_I 23_W 1.401 0.83
61_I 74_T 1.398 0.82
392_A 401_K 1.397 0.82
398_G 404_I 1.394 0.82
480_K 496_T 1.386 0.82
376_Q 520_S 1.381 0.81
316_K 319_A 1.379 0.81
152_T 162_T 1.358 0.80
83_L 98_Q 1.352 0.79
497_F 501_I 1.352 0.79
166_V 177_N 1.35 0.79
526_I 530_L 1.35 0.79
70_L 79_V 1.342 0.79
364_I 368_I 1.335 0.78
61_I 133_V 1.334 0.78
495_M 506_F 1.333 0.78
485_T 492_Q 1.333 0.78
448_Q 460_A 1.332 0.78
463_P 488_D 1.33 0.78
275_Y 287_G 1.319 0.77
14_F 20_W 1.316 0.77
63_V 72_I 1.316 0.77
11_A 15_V 1.295 0.75
432_I 436_L 1.293 0.75
160_T 181_Q 1.29 0.75
181_Q 300_T 1.289 0.75
69_D 85_P 1.285 0.74
401_K 404_I 1.267 0.73
62_S 71_T 1.264 0.73
359_I 452_A 1.263 0.73
185_E 297_P 1.26 0.72
72_I 149_V 1.255 0.72
31_P 53_P 1.254 0.72
17_F 21_Q 1.254 0.72
351_V 357_S 1.249 0.71
478_I 520_S 1.249 0.71
312_E 442_G 1.244 0.71
224_S 323_H 1.241 0.71
474_T 525_I 1.24 0.71
260_F 311_P 1.238 0.70
500_V 503_T 1.238 0.70
13_L 17_F 1.231 0.70
312_E 517_Y 1.219 0.69
382_K 407_E 1.218 0.69
430_M 433_F 1.216 0.68
168_K 175_N 1.214 0.68
62_S 69_D 1.211 0.68
135_K 138_Y 1.211 0.68
372_L 510_P 1.207 0.68
424_F 427_L 1.202 0.67
407_E 414_A 1.202 0.67
148_Q 166_V 1.198 0.67
376_Q 532_Y 1.195 0.67
365_V 436_L 1.194 0.66
81_Q 98_Q 1.193 0.66
382_K 385_M 1.19 0.66
12_L 15_V 1.19 0.66
48_A 55_S 1.189 0.66
366_R 369_M 1.184 0.65
254_A 327_T 1.183 0.65
471_M 528_Q 1.182 0.65
359_I 519_V 1.179 0.65
432_I 523_V 1.178 0.65
67_V 86_A 1.175 0.65
493_K 497_F 1.17 0.64
81_Q 101_E 1.165 0.64
100_L 340_L 1.162 0.63
111_Q 195_Q 1.159 0.63
346_W 350_F 1.157 0.63
9_V 16_S 1.156 0.63
39_T 51_G 1.154 0.63
39_T 50_Q 1.154 0.63
38_Q 49_D 1.15 0.62
494_I 504_V 1.148 0.62
72_I 336_I 1.143 0.61
408_M 412_Y 1.138 0.61
70_L 308_W 1.136 0.61
433_F 472_G 1.135 0.61
380_M 483_P 1.134 0.61
196_L 307_L 1.133 0.60
221_A 238_I 1.133 0.60
6_N 9_V 1.133 0.60
13_L 16_S 1.132 0.60
463_P 483_P 1.131 0.60
22_A 26_D 1.124 0.60
313_I 316_K 1.124 0.60
417_V 479_Q 1.124 0.60
522_L 526_I 1.121 0.59
134_E 162_T 1.12 0.59
386_L 479_Q 1.117 0.59
490_M 494_I 1.117 0.59
3_S 6_N 1.115 0.59
373_T 376_Q 1.115 0.59
434_L 438_Y 1.114 0.59
394_R 428_I 1.113 0.58
356_F 364_I 1.109 0.58
73_N 80_E 1.107 0.58
234_K 237_T 1.104 0.57
393_M 428_I 1.099 0.57
390_I 420_L 1.096 0.57
529_Q 533_R 1.095 0.57
474_T 521_N 1.094 0.56
4_Q 13_L 1.092 0.56
386_L 393_M 1.088 0.56
360_I 363_F 1.088 0.56
265_I 363_F 1.08 0.55
329_D 438_Y 1.079 0.55
38_Q 42_T 1.078 0.55
393_M 411_L 1.078 0.55
281_N 325_D 1.074 0.54
68_L 82_A 1.073 0.54
471_M 478_I 1.072 0.54
177_N 304_N 1.07 0.54
497_F 500_V 1.069 0.54
25_Q 32_Q 1.068 0.54
433_F 436_L 1.067 0.54
67_V 171_D 1.067 0.54
250_G 269_D 1.064 0.53
40_T 43_A 1.063 0.53
61_I 151_M 1.058 0.53
360_I 364_I 1.057 0.53
132_N 152_T 1.057 0.53
164_T 179_N 1.053 0.52
101_E 106_F 1.052 0.52
196_L 365_V 1.052 0.52
60_L 71_T 1.049 0.52
113_G 193_F 1.047 0.52
40_T 47_A 1.045 0.51
167_L 427_L 1.045 0.51
421_G 445_E 1.044 0.51
343_L 350_F 1.041 0.51
86_A 172_Y 1.04 0.51
432_I 535_L 1.039 0.51
35_Q 39_T 1.036 0.50
44_A 48_A 1.035 0.50
68_L 414_A 1.034 0.50
435_A 439_M 1.033 0.50
375_A 378_T 1.03 0.50
440_L 503_T 1.029 0.50
472_G 479_Q 1.026 0.49
354_W 359_I 1.024 0.49
353_N 455_I 1.024 0.49
148_Q 164_T 1.019 0.49
258_Q 442_G 1.018 0.48
15_V 25_Q 1.016 0.48
187_P 296_Q 1.016 0.48
393_M 397_L 1.015 0.48
261_A 308_W 1.015 0.48
99_L 495_M 1.014 0.48
413_K 445_E 1.014 0.48
521_N 531_I 1.013 0.48
7_L 10_I 1.011 0.48
393_M 408_M 1.006 0.47
258_Q 438_Y 1.006 0.47
389_K 455_I 1.005 0.47
37_T 49_D 1.003 0.47
308_W 316_K 1.002 0.47
163_K 178_Y 1 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3blcA20.58761000.664Contact Map0.725
3bs6A20.50361000.721Contact Map0.822
3q1nA10.408856.30.979Contact Map0.786
2cirA10.430715.80.984Contact Map0.771
1j8bA10.12045.30.987Contact Map0.49
2kygC10.06575.30.987Contact Map0.394
2mbyA10.08395.10.987Contact Map0.346
2jucA10.10044.70.988Contact Map0.448
4n7bA10.11864.20.988Contact Map
2ymyA20.06932.90.989Contact Map0.575
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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