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OPENSEQ.org
TEHA - Tellurite resistance protein TehA
UniProt: P25396 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11883
Length: 330 (315)
Sequences: 1008
Seq/Len: 3.20
TEHA
Paralog alert: 0.14 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
63_L 70_V 2.931 1.00
261_S 301_L 2.769 1.00
231_F 271_G 2.672 1.00
156_C 165_G 2.662 1.00
209_L 234_G 2.478 1.00
22_G 265_S 2.102 1.00
265_S 298_I 1.925 1.00
71_L 75_R 1.88 0.99
27_W 295_N 1.846 0.99
148_N 153_A 1.832 0.99
20_T 298_I 1.8 0.99
52_W 90_T 1.775 0.99
170_G 232_G 1.756 0.99
150_F 214_A 1.742 0.99
299_A 303_I 1.733 0.99
17_V 89_T 1.729 0.99
304_R 307_A 1.725 0.99
212_C 270_T 1.709 0.99
15_G 85_L 1.707 0.99
137_T 141_L 1.664 0.98
166_L 218_V 1.654 0.98
60_I 64_I 1.622 0.98
21_I 92_L 1.58 0.97
68_H 71_L 1.554 0.97
147_A 152_S 1.544 0.97
231_F 267_L 1.526 0.97
307_A 311_Q 1.52 0.97
153_A 156_C 1.516 0.96
209_L 213_S 1.492 0.96
148_N 154_M 1.478 0.96
39_W 60_I 1.472 0.96
238_L 267_L 1.425 0.94
20_T 51_I 1.424 0.94
27_W 291_F 1.422 0.94
148_N 155_A 1.418 0.94
17_V 51_I 1.397 0.94
104_L 107_C 1.396 0.94
76_H 80_S 1.371 0.93
76_H 186_R 1.365 0.93
61_A 65_R 1.361 0.93
118_A 177_L 1.359 0.92
11_A 73_E 1.358 0.92
26_A 291_F 1.344 0.92
84_S 139_P 1.341 0.92
36_V 40_L 1.338 0.92
149_N 155_A 1.337 0.92
275_G 287_A 1.335 0.92
296_F 300_I 1.315 0.91
150_F 154_M 1.31 0.91
81_S 140_G 1.31 0.91
194_P 197_L 1.307 0.90
30_A 288_V 1.303 0.90
306_F 310_M 1.302 0.90
147_A 155_A 1.293 0.90
91_M 94_A 1.283 0.89
39_W 43_G 1.283 0.89
296_F 299_A 1.278 0.89
200_S 256_S 1.267 0.89
109_F 156_C 1.266 0.88
45_V 96_G 1.255 0.88
19_G 305_T 1.248 0.87
19_G 146_V 1.239 0.87
24_G 41_G 1.238 0.87
147_A 153_A 1.237 0.87
16_I 55_L 1.233 0.87
292_I 296_F 1.231 0.87
57_S 60_I 1.228 0.86
255_A 294_T 1.227 0.86
87_P 115_V 1.227 0.86
107_C 111_F 1.205 0.85
59_F 62_R 1.191 0.84
48_A 52_W 1.191 0.84
210_V 266_A 1.18 0.83
147_A 156_C 1.175 0.83
235_L 267_L 1.166 0.82
22_G 269_T 1.165 0.82
19_G 261_S 1.158 0.82
32_Q 285_T 1.152 0.81
231_F 274_L 1.141 0.80
258_W 305_T 1.14 0.80
279_D 284_H 1.14 0.80
202_G 208_A 1.139 0.80
149_N 156_C 1.139 0.80
140_G 203_I 1.136 0.80
134_E 186_R 1.134 0.80
152_S 155_A 1.133 0.80
39_W 57_S 1.131 0.79
28_R 41_G 1.127 0.79
203_I 212_C 1.115 0.78
57_S 61_A 1.112 0.78
199_T 257_F 1.111 0.78
288_V 291_F 1.109 0.78
261_S 298_I 1.107 0.77
57_S 303_I 1.106 0.77
97_F 104_L 1.106 0.77
139_P 193_L 1.106 0.77
146_V 210_V 1.106 0.77
84_S 207_P 1.103 0.77
87_P 152_S 1.103 0.77
64_I 72_A 1.101 0.77
153_A 214_A 1.098 0.77
54_L 57_S 1.098 0.77
148_N 152_S 1.096 0.76
10_P 13_Y 1.096 0.76
24_G 48_A 1.094 0.76
36_V 43_G 1.094 0.76
273_H 276_S 1.092 0.76
154_M 157_G 1.091 0.76
18_L 85_L 1.09 0.76
149_N 153_A 1.089 0.76
37_S 246_P 1.088 0.76
87_P 116_Q 1.086 0.75
10_P 15_G 1.085 0.75
50_I 54_L 1.085 0.75
275_G 280_N 1.081 0.75
106_V 161_Y 1.081 0.75
202_G 206_A 1.075 0.74
205_L 267_L 1.073 0.74
53_G 102_R 1.071 0.74
211_A 214_A 1.071 0.74
64_I 107_C 1.067 0.74
88_A 109_F 1.067 0.74
268_A 290_L 1.065 0.73
104_L 114_V 1.064 0.73
227_A 280_N 1.062 0.73
199_T 260_F 1.062 0.73
61_A 239_L 1.057 0.73
62_R 73_E 1.055 0.72
62_R 200_S 1.054 0.72
108_L 117_L 1.054 0.72
141_L 301_L 1.052 0.72
31_S 36_V 1.046 0.72
107_C 303_I 1.045 0.71
38_H 42_D 1.044 0.71
150_F 153_A 1.041 0.71
24_G 96_G 1.041 0.71
181_P 268_A 1.037 0.71
43_G 302_L 1.036 0.71
176_W 207_P 1.034 0.70
142_Y 180_E 1.034 0.70
147_A 154_M 1.033 0.70
80_S 186_R 1.031 0.70
208_A 236_L 1.029 0.70
234_G 265_S 1.029 0.70
31_S 37_S 1.025 0.69
9_L 13_Y 1.022 0.69
238_L 290_L 1.018 0.69
150_F 207_P 1.013 0.68
147_A 151_I 1.012 0.68
84_S 87_P 1.01 0.68
253_F 301_L 1.01 0.68
152_S 159_L 1.01 0.68
30_A 40_L 1.009 0.68
160_G 194_P 1.009 0.68
67_P 118_A 1.005 0.67
56_T 86_F 1.002 0.67
101_F 218_V 1 0.67
32_Q 35_Q 1 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3m73A10.94551000.155Contact Map0.56
3mk7A40.22735.80.968Contact Map0.243
3j01B10.33943.10.972Contact Map0.147
2k9jB10.13032.40.974Contact Map0.355
2k9uB10.072720.975Contact Map0
2kncB10.178820.975Contact Map0.417
2l8sA10.163620.975Contact Map0.225
3l1lA10.20911.90.975Contact Map0.203
4gdoA60.05761.90.975Contact Map
3w9iA60.22731.80.975Contact Map0.281
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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