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OPENSEQ.org
HYPD - Hydrogenase isoenzymes formation protein HypD
UniProt: P24192 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10486
Length: 373 (367)
Sequences: 631
Seq/Len: 1.72
HYPD
Paralog alert: 0.02 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
133_Q 164_R 5.119 1.00
139_K 307_H 3.329 1.00
139_K 170_Y 3.142 1.00
183_R 217_D 3.039 1.00
130_K 134_E 2.845 1.00
212_N 260_D 2.832 1.00
225_A 235_G 2.807 1.00
159_Q 272_D 2.64 1.00
157_T 169_F 2.569 1.00
215_A 250_V 2.495 1.00
170_Y 307_H 2.494 1.00
62_E 332_K 2.491 1.00
158_L 295_L 2.457 1.00
92_I 135_N 2.447 1.00
326_V 331_C 2.44 1.00
238_M 251_E 2.294 1.00
177_T 180_P 2.236 0.99
112_A 117_A 2.217 0.99
203_S 211_Y 2.182 0.99
24_A 60_N 2.121 0.99
272_D 298_D 2.086 0.99
242_Q 251_E 2.08 0.99
195_A 239_L 2.066 0.99
212_N 216_S 2.026 0.99
322_R 331_C 2.012 0.99
300_Q 306_A 2.006 0.99
37_I 195_A 1.999 0.99
206_I 210_A 1.939 0.98
231_D 256_R 1.87 0.97
275_C 296_T 1.85 0.97
37_I 239_L 1.836 0.97
90_E 138_R 1.815 0.97
171_F 295_L 1.814 0.97
196_F 220_R 1.812 0.97
275_C 294_H 1.791 0.96
167_Q 301_R 1.788 0.96
39_E 45_T 1.771 0.96
162_K 301_R 1.752 0.96
204_M 257_V 1.718 0.95
40_V 178_L 1.695 0.95
80_D 105_K 1.694 0.95
187_E 218_F 1.68 0.94
183_R 187_E 1.678 0.94
107_G 115_R 1.672 0.94
128_A 169_F 1.633 0.93
133_Q 166_V 1.595 0.92
43_G 65_H 1.594 0.92
157_T 166_V 1.591 0.92
36_R 62_E 1.582 0.92
23_R 241_Q 1.539 0.90
2_R 6_E 1.529 0.90
3_F 6_E 1.519 0.89
208_T 224_V 1.514 0.89
322_R 325_E 1.499 0.89
65_H 176_I 1.485 0.88
82_C 172_F 1.462 0.87
129_L 166_V 1.453 0.87
234_Q 253_Q 1.431 0.85
264_L 267_Q 1.425 0.85
92_I 118_D 1.416 0.85
84_E 88_H 1.414 0.84
198_A 222_L 1.405 0.84
48_I 232_L 1.405 0.84
37_I 243_K 1.402 0.84
44_H 199_P 1.395 0.83
36_R 99_A 1.379 0.82
129_L 157_T 1.376 0.82
154_T 175_H 1.364 0.81
44_H 323_C 1.363 0.81
35_L 240_V 1.361 0.81
118_D 138_R 1.359 0.81
297_P 300_Q 1.347 0.80
23_R 240_V 1.344 0.80
234_Q 238_M 1.33 0.79
130_K 133_Q 1.329 0.79
93_F 143_F 1.326 0.79
92_I 138_R 1.325 0.79
338_L 349_F 1.32 0.78
268_Q 272_D 1.319 0.78
265_L 268_Q 1.316 0.78
184_S 288_I 1.313 0.78
261_A 264_L 1.288 0.76
80_D 104_G 1.282 0.76
223_V 251_E 1.277 0.75
322_R 326_V 1.277 0.75
85_I 141_V 1.275 0.75
13_V 230_L 1.274 0.75
238_M 253_Q 1.274 0.75
237_V 241_Q 1.25 0.73
247_H 251_E 1.245 0.72
46_H 65_H 1.24 0.72
92_I 131_L 1.226 0.71
63_F 236_V 1.223 0.71
199_P 352_L 1.222 0.70
125_P 157_T 1.213 0.70
43_G 176_I 1.206 0.69
279_D 287_V 1.204 0.69
17_I 21_R 1.204 0.69
90_E 139_K 1.204 0.69
35_L 243_K 1.201 0.69
92_I 120_R 1.195 0.68
33_R 194_D 1.188 0.67
151_M 270_I 1.185 0.67
59_E 134_E 1.185 0.67
44_H 352_L 1.185 0.67
177_T 181_T 1.175 0.66
107_G 112_A 1.172 0.66
162_K 302_F 1.168 0.65
321_A 352_L 1.161 0.65
20_L 240_V 1.161 0.65
23_R 237_V 1.156 0.64
208_T 260_D 1.148 0.63
213_F 217_D 1.146 0.63
264_L 268_Q 1.146 0.63
282_W 291_S 1.142 0.63
228_E 231_D 1.136 0.62
75_P 176_I 1.129 0.62
45_T 362_A 1.128 0.61
96_F 125_P 1.125 0.61
17_I 233_L 1.125 0.61
160_Q 164_R 1.122 0.61
63_F 200_G 1.12 0.61
48_I 63_F 1.119 0.60
44_H 108_S 1.113 0.60
50_K 195_A 1.109 0.59
58_P 327_L 1.104 0.59
208_T 212_N 1.104 0.59
77_G 281_E 1.098 0.58
323_C 352_L 1.098 0.58
293_V 310_P 1.096 0.58
297_P 306_A 1.089 0.57
183_R 213_F 1.088 0.57
158_L 162_K 1.085 0.57
43_G 46_H 1.083 0.57
37_I 224_V 1.077 0.56
81_T 305_E 1.074 0.56
275_C 297_P 1.07 0.55
123_Y 127_D 1.067 0.55
40_V 224_V 1.064 0.55
241_Q 245_A 1.058 0.54
209_D 261_A 1.051 0.53
151_M 293_V 1.05 0.53
223_V 238_M 1.046 0.53
78_R 174_Q 1.046 0.53
238_M 242_Q 1.045 0.53
159_Q 273_V 1.035 0.52
10_P 14_M 1.035 0.52
43_G 198_A 1.024 0.50
181_T 293_V 1.018 0.50
39_E 362_A 1.018 0.50
61_V 240_V 1.014 0.49
44_H 203_S 1.014 0.49
57_L 324_G 1.014 0.49
145_L 203_S 1.013 0.49
200_G 326_V 1.013 0.49
94_C 131_L 1.011 0.49
162_K 298_D 1.01 0.49
43_G 78_R 1.007 0.49
104_G 292_G 1.005 0.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2z1dA20.97321000.032Contact Map0.7
1reqA20.544289.70.97Contact Map0.448
2q5cA20.490679.50.974Contact Map0.198
2vsyA20.68176.40.974Contact Map0.306
2xijA10.619365.40.976Contact Map0.424
4hwgA10.683648.50.979Contact Map0.166
1qopA10.624745.80.979Contact Map0.233
2m46A10.305639.90.98Contact Map0.366
3qhpA20.434334.70.98Contact Map0.231
3purA20.176931.70.981Contact Map0
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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