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OPENSEQ.org
FOLD - Bifunctional protein FolD
UniProt: P24186 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10328
Length: 288 (283)
Sequences: 2315
Seq/Len: 8.18
FOLD
Paralog alert: 0.08 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_K 280_V 3.883 1.00
84_D 113_R 3.377 1.00
195_N 198_H 3.371 1.00
161_N 202_N 3.364 1.00
151_E 182_A 3.352 1.00
245_V 248_D 3.274 1.00
165_I 216_I 2.904 1.00
76_E 109_K 2.887 1.00
14_Q 152_R 2.708 1.00
82_L 85_T 2.688 1.00
223_E 252_R 2.68 1.00
161_N 199_H 2.677 1.00
7_D 10_T 2.533 1.00
84_D 88_A 2.529 1.00
210_V 215_F 2.494 1.00
157_T 205_L 2.469 1.00
80_L 113_R 2.451 1.00
206_L 221_I 2.449 1.00
32_R 93_D 2.368 1.00
221_I 249_A 2.284 1.00
74_T 79_L 2.279 1.00
217_P 220_W 2.27 1.00
5_I 246_F 2.142 1.00
35_G 66_R 2.127 1.00
218_G 248_D 2.119 1.00
158_F 183_G 2.058 1.00
214_G 245_V 2.036 1.00
123_F 170_I 2.022 1.00
200_V 206_L 2.016 1.00
57_A 268_V 1.993 1.00
68_Y 82_L 1.965 1.00
162_A 179_L 1.924 1.00
226_I 254_S 1.882 1.00
97_V 110_V 1.877 1.00
147_V 182_A 1.871 1.00
176_S 188_V 1.856 1.00
16_R 60_E 1.856 1.00
18_E 152_R 1.841 1.00
49_I 240_V 1.825 1.00
148_T 151_E 1.821 1.00
197_R 201_E 1.799 1.00
160_L 194_K 1.755 1.00
27_I 33_A 1.713 1.00
20_A 24_Q 1.698 1.00
246_F 256_I 1.666 1.00
73_T 78_E 1.642 1.00
19_V 276_L 1.64 1.00
199_H 202_N 1.632 1.00
61_V 272_I 1.629 1.00
66_R 92_I 1.614 1.00
148_T 273_E 1.606 1.00
204_D 222_K 1.6 1.00
200_V 220_W 1.579 1.00
70_L 74_T 1.556 1.00
64_V 92_I 1.556 1.00
43_S 48_Q 1.542 1.00
180_L 188_V 1.528 1.00
76_E 80_L 1.512 1.00
43_S 72_E 1.509 1.00
138_L 278_A 1.506 1.00
158_F 192_F 1.49 1.00
35_G 64_V 1.481 0.99
244_V 249_A 1.476 0.99
19_V 61_V 1.464 0.99
227_V 244_V 1.456 0.99
132_C 177_M 1.454 0.99
148_T 270_T 1.451 0.99
164_V 175_M 1.421 0.99
70_L 82_L 1.418 0.99
218_G 249_A 1.4 0.99
198_H 202_N 1.394 0.99
217_P 245_V 1.391 0.99
148_T 152_R 1.389 0.99
21_Q 24_Q 1.388 0.99
11_I 153_Y 1.385 0.99
139_R 178_E 1.384 0.99
17_S 21_Q 1.37 0.99
221_I 225_A 1.367 0.99
40_L 48_Q 1.365 0.99
16_R 57_A 1.361 0.99
156_D 160_L 1.36 0.99
4_K 255_Y 1.353 0.99
144_R 273_E 1.338 0.99
76_E 106_D 1.315 0.98
189_T 193_T 1.314 0.98
206_L 216_I 1.305 0.98
214_G 241_V 1.274 0.98
163_V 203_A 1.274 0.98
64_V 91_T 1.253 0.98
155_I 255_Y 1.252 0.98
167_A 191_R 1.24 0.98
189_T 199_H 1.24 0.98
167_A 183_G 1.222 0.97
144_R 277_Q 1.221 0.97
52_A 56_K 1.22 0.97
197_R 219_D 1.213 0.97
58_C 272_I 1.198 0.97
147_V 151_E 1.192 0.97
15_V 19_V 1.186 0.97
93_D 282_Y 1.185 0.97
23_V 63_F 1.171 0.96
218_G 252_R 1.164 0.96
212_K 215_F 1.164 0.96
76_E 105_I 1.162 0.96
51_V 98_Q 1.159 0.96
37_A 86_L 1.159 0.96
163_V 189_T 1.157 0.96
277_Q 281_E 1.155 0.96
25_A 29_A 1.147 0.96
222_K 225_A 1.141 0.95
145_G 266_M 1.139 0.95
247_E 250_A 1.139 0.95
56_K 60_E 1.137 0.95
9_K 13_Q 1.124 0.95
37_A 92_I 1.119 0.95
106_D 109_K 1.116 0.95
39_V 86_L 1.112 0.95
235_L 239_K 1.105 0.94
35_G 92_I 1.102 0.94
162_A 184_C 1.09 0.94
165_I 206_L 1.082 0.94
214_G 247_E 1.079 0.93
185_T 193_T 1.069 0.93
10_T 14_Q 1.068 0.93
99_L 111_L 1.067 0.93
24_Q 28_A 1.065 0.93
75_S 78_E 1.064 0.93
49_I 53_S 1.063 0.93
217_P 248_D 1.06 0.93
249_A 256_I 1.056 0.92
74_T 82_L 1.048 0.92
160_L 205_L 1.04 0.92
163_V 199_H 1.036 0.91
77_A 81_E 1.034 0.91
150_L 153_Y 1.027 0.91
6_I 11_I 1.025 0.91
55_R 67_S 1.024 0.91
128_V 132_C 1.018 0.90
124_H 127_N 1.015 0.90
63_F 276_L 1.013 0.90
25_A 28_A 1.006 0.90
246_F 250_A 1.004 0.90
189_T 196_L 1.002 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4b4uA20.97921000.282Contact Map0.784
4a5oA40.98611000.305Contact Map0.768
2c2xA20.96881000.306Contact Map0.774
1b0aA111000.307Contact Map0.722
3l07A20.98261000.308Contact Map0.79
4a26A20.99311000.321Contact Map0.809
3p2oA20.97571000.333Contact Map0.797
1a4iA211000.352Contact Map0.839
1edzA10.94441000.434Contact Map0.636
3ngxA20.95491000.442Contact Map0.703
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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