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OPENSEQ.org
YIFB - Uncharacterized protein YifB
UniProt: P22787 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11260
Length: 506 (494)
Sequences: 1417
Seq/Len: 2.87
YIFB
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
190_L 406_V 4.925 1.00
204_E 409_R 3.92 1.00
477_S 484_H 3.609 1.00
116_L 157_A 3.434 1.00
201_R 487_E 3.383 1.00
23_V 88_A 3.361 1.00
245_S 295_N 3.343 1.00
401_E 409_R 3.176 1.00
157_A 163_V 3.138 1.00
140_K 158_D 3.11 1.00
321_G 337_R 3.102 1.00
440_E 443_D 3.028 1.00
32_L 67_I 3.016 1.00
205_I 471_I 2.82 1.00
225_M 229_R 2.812 1.00
204_E 401_E 2.805 1.00
401_E 406_V 2.775 1.00
204_E 406_V 2.774 1.00
158_D 162_A 2.696 1.00
267_R 289_E 2.664 1.00
322_Q 333_T 2.637 1.00
135_K 153_G 2.636 1.00
126_A 136_I 2.631 1.00
402_S 405_T 2.622 1.00
347_S 359_C 2.574 1.00
233_L 403_S 2.475 1.00
406_V 409_R 2.458 1.00
303_L 342_A 2.452 1.00
87_I 106_L 2.369 1.00
192_D 229_R 2.36 1.00
106_L 137_I 2.344 1.00
213_L 341_V 2.262 1.00
241_E 264_R 2.246 1.00
381_L 467_V 2.235 1.00
278_M 310_T 2.227 1.00
205_I 381_L 2.188 1.00
91_A 101_L 2.185 1.00
413_A 474_I 2.148 1.00
203_L 226_L 2.145 1.00
273_A 277_A 2.145 1.00
295_N 427_W 2.143 1.00
208_A 474_I 2.128 1.00
104_Y 135_K 2.115 1.00
108_G 139_A 2.059 1.00
236_D 411_M 2.045 1.00
443_D 485_L 2.037 1.00
433_I 466_K 2.035 1.00
193_V 229_R 2.031 1.00
210_G 426_A 2.029 1.00
24_H 55_N 2.023 1.00
475_D 484_H 2.02 1.00
246_A 261_W 2.013 1.00
349_T 359_C 1.998 1.00
126_A 152_E 1.971 1.00
450_T 489_V 1.952 0.99
208_A 413_A 1.944 0.99
7_H 18_P 1.942 0.99
311_L 375_F 1.894 0.99
434_R 462_Q 1.89 0.99
272_S 313_A 1.89 0.99
477_S 481_T 1.879 0.99
279_V 290_I 1.85 0.99
437_C 480_I 1.825 0.99
354_G 387_L 1.822 0.99
360_T 363_Q 1.806 0.99
203_L 230_I 1.802 0.99
230_I 341_V 1.79 0.99
439_L 443_D 1.779 0.99
9_R 105_E 1.758 0.99
421_Q 428_L 1.75 0.99
407_K 411_M 1.737 0.98
405_T 408_Q 1.692 0.98
423_K 432_E 1.688 0.98
404_A 408_Q 1.686 0.98
207_A 230_I 1.657 0.98
210_G 424_L 1.627 0.97
273_A 278_M 1.626 0.97
128_E 131_K 1.624 0.97
232_G 403_S 1.613 0.97
228_S 320_S 1.604 0.97
285_P 334_Y 1.6 0.97
137_I 163_V 1.587 0.97
190_L 213_L 1.58 0.97
475_D 483_Q 1.56 0.96
10_A 81_Y 1.538 0.96
53_I 60_Y 1.527 0.96
107_V 125_S 1.512 0.96
87_I 163_V 1.5 0.95
116_L 163_V 1.5 0.95
388_P 392_I 1.5 0.95
299_F 343_A 1.492 0.95
429_D 432_E 1.486 0.95
21_V 84_P 1.477 0.95
207_A 234_L 1.471 0.95
307_E 310_T 1.47 0.95
412_A 416_R 1.469 0.95
199_G 226_L 1.468 0.95
237_L 245_S 1.464 0.94
159_H 162_A 1.46 0.94
91_A 96_L 1.46 0.94
143_E 156_I 1.458 0.94
237_L 264_R 1.456 0.94
40_T 43_K 1.435 0.94
304_P 344_M 1.429 0.93
8_T 81_Y 1.419 0.93
464_L 489_V 1.406 0.93
192_D 225_M 1.391 0.92
53_I 56_S 1.376 0.92
391_G 448_E 1.362 0.91
272_S 276_T 1.356 0.91
290_I 323_I 1.345 0.90
17_P 74_L 1.343 0.90
24_H 54_I 1.339 0.90
224_T 320_S 1.338 0.90
303_L 311_L 1.334 0.90
53_I 160_L 1.333 0.90
415_E 419_K 1.328 0.90
188_H 232_G 1.316 0.89
303_L 375_F 1.303 0.88
86_A 110_L 1.294 0.88
487_E 491_Y 1.293 0.88
267_R 292_L 1.279 0.87
130_I 151_G 1.279 0.87
156_I 173_L 1.278 0.87
203_L 213_L 1.271 0.87
308_R 312_D 1.271 0.87
81_Y 291_S 1.27 0.87
215_L 381_L 1.27 0.87
9_R 125_S 1.263 0.86
104_Y 137_I 1.258 0.86
106_L 163_V 1.254 0.86
165_A 170_K 1.252 0.86
415_E 418_F 1.251 0.86
337_R 427_W 1.251 0.86
103_E 134_R 1.245 0.85
161_Q 165_A 1.244 0.85
122_A 138_V 1.243 0.85
290_I 338_F 1.241 0.85
200_K 401_E 1.24 0.85
155_L 166_F 1.234 0.84
446_W 486_Q 1.227 0.84
312_D 372_S 1.22 0.84
157_A 173_L 1.216 0.83
440_E 481_T 1.2 0.82
412_A 476_Q 1.198 0.82
238_S 241_E 1.197 0.82
128_E 132_S 1.197 0.82
122_A 146_V 1.197 0.82
104_Y 166_F 1.196 0.82
389_P 392_I 1.191 0.82
242_A 261_W 1.188 0.81
143_E 147_G 1.188 0.81
379_F 382_S 1.187 0.81
481_T 484_H 1.186 0.81
199_G 385_I 1.184 0.81
428_L 466_K 1.184 0.81
143_E 154_C 1.178 0.81
86_A 160_L 1.176 0.80
215_L 383_L 1.173 0.80
279_V 323_I 1.173 0.80
122_A 126_A 1.162 0.79
190_L 233_L 1.158 0.79
349_T 353_Q 1.156 0.79
416_R 478_D 1.153 0.79
157_A 166_F 1.151 0.78
166_F 173_L 1.144 0.78
411_M 415_E 1.137 0.77
300_L 340_L 1.126 0.76
21_V 69_L 1.124 0.76
162_A 171_H 1.123 0.76
224_T 228_S 1.121 0.76
469_R 480_I 1.117 0.75
348_P 366_R 1.114 0.75
234_L 297_V 1.099 0.74
110_L 160_L 1.096 0.73
471_I 487_E 1.094 0.73
135_K 155_L 1.092 0.73
145_E 250_S 1.089 0.73
60_Y 89_L 1.089 0.73
129_A 136_I 1.088 0.73
286_G 329_R 1.087 0.73
25_I 93_S 1.084 0.72
353_Q 368_L 1.079 0.72
295_N 337_R 1.075 0.71
457_S 460_A 1.074 0.71
324_H 333_T 1.072 0.71
111_A 117_R 1.071 0.71
34_M 85_I 1.071 0.71
347_S 353_Q 1.071 0.71
122_A 142_N 1.07 0.71
433_I 437_C 1.065 0.70
214_L 344_M 1.053 0.69
362_E 366_R 1.05 0.69
106_L 116_L 1.037 0.67
138_V 154_C 1.033 0.67
65_I 89_L 1.033 0.67
239_N 262_R 1.029 0.67
69_L 85_I 1.019 0.65
446_W 482_R 1.018 0.65
47_D 50_R 1.017 0.65
439_L 444_A 1.012 0.65
122_A 147_G 1.011 0.65
408_Q 412_A 1.01 0.64
47_D 60_Y 1.009 0.64
56_S 159_H 1.008 0.64
32_L 41_T 1.002 0.64
440_E 479_I 1 0.63
58_Y 95_Q 1 0.63
210_G 414_R 1 0.63
208_A 470_T 1 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2x36A60.35181000.807Contact Map0.808
1rreA60.35181000.809Contact Map0.782
1xhkA20.3341000.81Contact Map0.733
1z0wA10.36761000.813Contact Map0.778
3m6aA60.35181000.823Contact Map0.695
1g8pA10.59681000.828Contact Map0.634
3k1jA20.37941000.835Contact Map0.796
3f8tA10.78261000.842Contact Map0.584
4fwgA10.38341000.854Contact Map0.751
4fdgB50.84981000.861Contact Map0.377
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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