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OPENSEQ.org
SYC - Cysteine--tRNA ligase
UniProt: P21888 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10196
Length: 461 (459)
Sequences: 3682
Seq/Len: 8.02
SYC
Paralog alert: 0.50 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
126_E 130_A 4.754 1.00
101_D 107_R 4.546 1.00
133_H 148_T 4.186 1.00
434_A 437_A 3.764 1.00
425_D 429_A 3.73 1.00
195_P 200_A 3.704 1.00
145_D 176_R 3.672 1.00
22_E 60_K 3.6 1.00
422_Q 434_A 3.379 1.00
6_N 13_E 3.332 1.00
120_E 215_K 3.165 1.00
431_D 434_A 3.158 1.00
50_V 350_F 3.01 1.00
4_I 255_M 2.964 1.00
131_K 244_C 2.89 1.00
55_R 106_L 2.806 1.00
57_L 347_D 2.697 1.00
147_P 177_N 2.641 1.00
420_I 449_L 2.567 1.00
340_A 344_E 2.475 1.00
83_E 91_R 2.425 1.00
51_A 55_R 2.412 1.00
45_V 293_L 2.4 1.00
35_L 95_E 2.372 1.00
127_Q 130_A 2.356 1.00
217_L 242_S 2.347 1.00
421_Q 425_D 2.342 1.00
450_E 459_R 2.339 1.00
124_L 245_A 2.314 1.00
417_E 421_Q 2.283 1.00
127_Q 131_K 2.226 1.00
19_H 24_G 2.203 1.00
54_L 59_Y 2.19 1.00
94_A 98_K 2.18 1.00
265_E 271_L 2.175 1.00
283_Y 306_E 2.149 1.00
7_T 231_M 2.074 1.00
43_T 257_S 2.065 1.00
437_A 441_R 2.056 1.00
418_A 422_Q 2.031 1.00
12_K 348_D 2.011 1.00
53_Y 346_M 2.008 1.00
145_D 148_T 1.993 1.00
95_E 98_K 1.971 1.00
49_V 294_M 1.971 1.00
441_R 444_E 1.906 1.00
97_H 111_E 1.903 1.00
67_I 93_I 1.899 1.00
219_N 248_G 1.89 1.00
19_H 22_E 1.888 1.00
3_K 14_E 1.844 1.00
117_H 216_Q 1.837 1.00
279_D 282_K 1.837 1.00
114_A 121_I 1.788 1.00
449_L 456_T 1.759 1.00
57_L 343_I 1.753 1.00
74_I 85_F 1.752 1.00
77_R 80_E 1.743 1.00
431_D 437_A 1.731 1.00
341_R 358_V 1.704 1.00
55_R 109_D 1.7 1.00
9_T 13_E 1.676 1.00
188_K 191_E 1.669 1.00
123_E 126_E 1.667 1.00
83_E 88_M 1.652 1.00
151_T 154_V 1.65 1.00
213_N 221_F 1.64 1.00
345_A 354_E 1.635 1.00
440_D 444_E 1.628 1.00
83_E 87_A 1.628 1.00
90_D 94_A 1.623 1.00
210_S 242_S 1.588 1.00
252_N 350_F 1.577 1.00
123_E 127_Q 1.57 1.00
447_I 458_W 1.536 1.00
44_F 105_I 1.536 1.00
86_V 90_D 1.532 1.00
419_L 422_Q 1.517 1.00
50_V 255_M 1.517 1.00
306_E 310_K 1.495 1.00
441_R 445_M 1.494 1.00
426_A 431_D 1.491 0.99
34_D 40_H 1.484 0.99
133_H 244_C 1.476 0.99
287_E 320_Y 1.475 0.99
419_L 441_R 1.466 0.99
450_E 457_T 1.465 0.99
27_V 225_G 1.465 0.99
76_K 80_E 1.464 0.99
27_V 51_A 1.459 0.99
53_Y 57_L 1.457 0.99
47_F 225_G 1.456 0.99
35_L 92_M 1.444 0.99
319_L 363_A 1.432 0.99
452_G 457_T 1.429 0.99
127_Q 245_A 1.425 0.99
4_I 350_F 1.421 0.99
65_R 111_E 1.404 0.99
5_F 10_R 1.392 0.99
62_K 110_M 1.389 0.99
18_I 252_N 1.388 0.99
342_F 358_V 1.384 0.99
15_F 253_Y 1.379 0.99
102_A 282_K 1.379 0.99
280_V 289_V 1.372 0.99
23_V 59_Y 1.371 0.99
117_H 215_K 1.371 0.99
424_L 428_K 1.367 0.99
354_E 357_S 1.346 0.99
337_A 341_R 1.346 0.99
46_A 294_M 1.339 0.99
351_N 354_E 1.331 0.99
53_Y 347_D 1.327 0.99
213_N 217_L 1.324 0.99
131_K 247_D 1.305 0.98
442_L 447_I 1.3 0.98
159_D 162_Q 1.294 0.98
44_F 100_F 1.284 0.98
452_G 455_G 1.28 0.98
97_H 101_D 1.279 0.98
228_S 259_M 1.279 0.98
24_G 221_F 1.279 0.98
207_I 210_S 1.276 0.98
49_V 352_T 1.261 0.98
4_I 50_V 1.26 0.98
422_Q 437_A 1.248 0.98
117_H 120_E 1.245 0.98
322_A 363_A 1.238 0.97
81_N 88_M 1.234 0.97
51_A 109_D 1.229 0.97
126_E 129_I 1.229 0.97
339_E 386_K 1.227 0.97
428_K 432_W 1.219 0.97
51_A 61_L 1.217 0.97
22_E 62_K 1.216 0.97
315_A 360_F 1.216 0.97
36_C 40_H 1.209 0.97
262_V 274_F 1.205 0.97
98_K 102_A 1.203 0.97
51_A 106_L 1.196 0.97
40_H 44_F 1.191 0.97
341_R 344_E 1.189 0.97
307_E 311_Q 1.186 0.96
212_M 216_Q 1.181 0.96
45_V 105_I 1.179 0.96
427_R 435_A 1.178 0.96
154_V 243_T 1.176 0.96
2_L 347_D 1.175 0.96
424_L 456_T 1.175 0.96
388_S 394_L 1.174 0.96
84_S 87_A 1.17 0.96
417_E 458_W 1.17 0.96
102_A 281_L 1.167 0.96
420_I 456_T 1.167 0.96
25_M 223_I 1.167 0.96
417_E 420_I 1.166 0.96
81_N 91_R 1.163 0.96
220_H 252_N 1.161 0.96
434_A 441_R 1.159 0.96
90_D 113_R 1.159 0.96
10_R 157_R 1.156 0.96
35_L 278_R 1.155 0.96
144_F 244_C 1.151 0.96
214_C 246_H 1.149 0.96
124_L 211_A 1.135 0.95
358_V 361_D 1.133 0.95
56_F 343_I 1.13 0.95
292_F 312_A 1.127 0.95
214_C 219_N 1.125 0.95
2_L 15_F 1.123 0.95
212_M 217_L 1.119 0.95
110_M 216_Q 1.112 0.94
217_L 221_F 1.109 0.94
108_P 111_E 1.108 0.94
67_I 108_P 1.108 0.94
122_I 126_E 1.101 0.94
267_M 273_N 1.098 0.94
113_R 116_H 1.096 0.94
414_A 418_A 1.093 0.94
36_C 99_D 1.088 0.94
25_M 51_A 1.086 0.93
291_Y 315_A 1.081 0.93
71_D 75_I 1.08 0.93
249_Q 252_N 1.079 0.93
220_H 248_G 1.079 0.93
2_L 57_L 1.078 0.93
279_D 283_Y 1.075 0.93
213_N 216_Q 1.074 0.93
415_E 418_A 1.069 0.93
141_D 174_D 1.067 0.93
424_L 427_R 1.065 0.93
28_C 31_T 1.059 0.92
15_F 23_V 1.048 0.92
342_F 355_A 1.048 0.92
128_L 131_K 1.044 0.92
54_L 348_D 1.043 0.92
433_A 437_A 1.038 0.91
263_D 303_N 1.038 0.91
154_V 239_I 1.032 0.91
16_K 252_N 1.032 0.91
121_I 207_I 1.029 0.91
81_N 92_M 1.026 0.91
145_D 177_N 1.023 0.90
158_Q 163_L 1.021 0.90
87_A 90_D 1.019 0.90
67_I 97_H 1.018 0.90
149_D 244_C 1.017 0.90
99_D 278_R 1.013 0.90
44_F 96_M 1.008 0.90
260_V 302_L 1.008 0.90
415_E 441_R 1.003 0.89
98_K 101_D 1.003 0.89
232_F 236_E 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1li5A20.83731000.159Contact Map0.709
3tqoA10.83081000.172Contact Map0.791
3sp1A20.90241000.22Contact Map0.667
3c8zA20.80911000.38Contact Map0.742
4lneA30.8721000.482Contact Map0.574
4dlpA30.87421000.482Contact Map0.568
3kflA10.90671000.494Contact Map0.53
2x1lA30.89591000.503Contact Map0.61
3ziuA20.94791000.518Contact Map0.534
3u1fA20.91321000.524Contact Map0.627
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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