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OPENSEQ.org
LPXD - UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
UniProt: P21645 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10316
Length: 341 (337)
Sequences: 1154
Seq/Len: 3.42
LPXD
Paralog alert: 0.09 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
37_G 57_S 4.049 1.00
169_N 206_R 3.816 1.00
134_V 152_S 2.965 1.00
200_R 222_D 2.956 1.00
231_I 235_C 2.948 1.00
150_A 168_Q 2.898 1.00
329_R 334_E 2.842 1.00
107_D 126_S 2.773 1.00
129_E 147_K 2.701 1.00
246_N 264_Y 2.694 1.00
204_G 227_N 2.641 1.00
151_G 169_N 2.572 1.00
326_M 330_L 2.512 1.00
133_N 151_G 2.47 1.00
15_A 74_L 2.466 1.00
227_N 245_D 2.465 1.00
172_I 176_T 2.442 1.00
112_L 116_V 2.418 1.00
226_G 245_D 2.415 1.00
245_D 263_R 2.397 1.00
113_G 132_D 2.369 1.00
111_K 129_E 2.36 1.00
107_D 110_A 2.314 1.00
288_M 305_I 2.257 1.00
175_G 212_C 2.235 1.00
152_S 168_Q 2.224 1.00
274_N 277_M 2.216 1.00
76_V 82_T 2.195 1.00
264_Y 282_K 2.172 1.00
112_L 118_I 2.161 1.00
152_S 170_C 2.152 1.00
263_R 281_D 2.143 1.00
145_N 163_E 2.14 1.00
125_E 144_K 2.086 1.00
114_N 132_D 2.05 1.00
27_G 38_H 1.998 1.00
267_I 273_I 1.992 1.00
113_G 116_V 1.989 1.00
168_Q 205_D 1.988 1.00
127_G 145_N 1.987 1.00
134_V 168_Q 1.963 1.00
121_N 139_G 1.937 1.00
139_G 157_N 1.892 1.00
115_N 133_N 1.877 1.00
103_S 121_N 1.867 0.99
176_T 213_T 1.837 0.99
203_I 209_I 1.837 0.99
229_V 247_T 1.836 0.99
87_A 196_P 1.833 0.99
280_C 283_V 1.832 0.99
205_D 227_N 1.816 0.99
140_C 154_L 1.802 0.99
122_A 136_I 1.799 0.99
109_T 127_G 1.794 0.99
161_Y 174_S 1.792 0.99
132_D 150_A 1.761 0.99
181_D 194_K 1.755 0.99
241_V 255_M 1.732 0.99
242_V 260_K 1.723 0.99
164_I 200_R 1.717 0.99
286_T 303_S 1.708 0.99
229_V 263_R 1.701 0.99
270_A 288_M 1.682 0.99
214_T 234_Q 1.675 0.99
212_C 234_Q 1.669 0.99
121_N 157_N 1.661 0.99
218_G 222_D 1.652 0.98
31_M 40_T 1.621 0.98
262_G 281_D 1.584 0.98
260_K 278_E 1.577 0.98
147_K 165_Q 1.542 0.97
7_A 21_G 1.515 0.97
194_K 208_E 1.514 0.97
226_G 242_V 1.511 0.97
280_C 296_T 1.511 0.97
252_G 270_A 1.502 0.97
254_I 272_V 1.47 0.96
289_G 307_L 1.466 0.96
25_I 58_A 1.454 0.96
6_L 58_A 1.436 0.95
249_V 267_I 1.432 0.95
80_Y 186_A 1.43 0.95
142_V 146_S 1.429 0.95
63_Q 77_K 1.405 0.95
128_V 146_S 1.401 0.95
247_T 265_C 1.378 0.94
285_V 291_V 1.37 0.94
130_L 134_V 1.354 0.93
267_I 271_S 1.337 0.93
209_I 215_I 1.322 0.92
180_A 211_A 1.32 0.92
140_C 158_V 1.316 0.92
204_G 226_G 1.315 0.92
197_Q 219_A 1.314 0.92
160_I 164_I 1.313 0.92
142_V 154_L 1.302 0.91
109_T 126_S 1.299 0.91
249_V 253_V 1.296 0.91
247_T 263_R 1.283 0.90
29_A 38_H 1.28 0.90
44_N 47_Y 1.271 0.90
211_A 214_T 1.263 0.89
34_A 56_A 1.263 0.89
228_G 246_N 1.26 0.89
12_Q 89_I 1.254 0.89
171_L 208_E 1.238 0.88
51_L 59_V 1.229 0.88
280_C 297_E 1.226 0.87
101_A 105_V 1.225 0.87
115_N 132_D 1.205 0.86
124_I 136_I 1.202 0.86
116_V 134_V 1.197 0.86
266_M 284_T 1.193 0.86
278_E 294_P 1.174 0.84
131_G 150_A 1.171 0.84
5_R 24_V 1.167 0.84
154_L 160_I 1.157 0.83
280_C 298_P 1.157 0.83
186_A 275_G 1.148 0.82
309_P 312_V 1.146 0.82
303_S 310_N 1.145 0.82
178_V 203_I 1.142 0.82
116_V 132_D 1.141 0.82
165_Q 202_I 1.14 0.82
286_T 310_N 1.134 0.81
105_V 121_N 1.13 0.81
226_G 263_R 1.126 0.81
247_T 261_I 1.123 0.80
330_L 333_L 1.12 0.80
134_V 148_I 1.119 0.80
267_I 285_V 1.117 0.80
173_Q 180_A 1.116 0.80
34_A 38_H 1.107 0.79
202_I 224_I 1.1 0.79
166_I 170_C 1.097 0.78
125_E 128_V 1.084 0.77
173_Q 194_K 1.084 0.77
8_D 11_Q 1.08 0.77
15_A 76_V 1.079 0.77
240_N 258_S 1.075 0.76
5_R 8_D 1.075 0.76
253_V 267_I 1.064 0.75
134_V 150_A 1.059 0.75
160_I 178_V 1.057 0.75
287_G 290_M 1.057 0.75
255_M 259_L 1.053 0.74
303_S 313_W 1.048 0.74
213_T 236_Q 1.042 0.73
9_L 86_M 1.04 0.73
124_I 128_V 1.037 0.73
122_A 140_C 1.03 0.72
149_G 168_Q 1.027 0.71
171_L 181_D 1.024 0.71
106_I 110_A 1.021 0.71
202_I 222_D 1.02 0.71
26_T 37_G 1.018 0.71
128_V 143_G 1.018 0.71
23_I 57_S 1.015 0.70
146_S 200_R 1.012 0.70
60_V 76_V 1.01 0.70
36_T 55_Q 1.006 0.69
159_T 175_G 1.005 0.69
224_I 242_V 1.003 0.69
16_E 63_Q 1.003 0.69
18_H 75_V 1.001 0.69
154_L 158_V 1.001 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pmoA10.99711000.323Contact Map0.752
2iu8A30.99711000.331Contact Map0.86
4ihfA611000.371Contact Map0.899
3eh0A311000.371Contact Map0.893
4e79A30.99411000.385Contact Map0.851
3t57A10.71551000.586Contact Map0.766
2pigA20.81521000.639Contact Map0.451
3fs8A20.66861000.657Contact Map0.813
3hsqA30.64221000.661Contact Map0.809
1j2zA10.64221000.665Contact Map0.817
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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