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CYSD - Sulfate adenylyltransferase subunit 2
UniProt: P21156 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10186
Length: 302 (298)
Sequences: 627
Seq/Len: 2.10
CYSD
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
10_R 200_L 4.783 1.00
263_Q 267_E 4.506 1.00
93_P 97_A 4.445 1.00
78_R 82_A 4.17 1.00
61_L 122_A 3.527 1.00
74_E 78_R 3.412 1.00
199_W 266_P 3.174 1.00
213_E 241_K 3.103 1.00
243_M 261_N 2.841 1.00
219_R 237_E 2.677 1.00
215_P 241_K 2.582 1.00
45_H 48_R 2.569 1.00
242_R 259_E 2.476 1.00
31_V 61_L 2.442 1.00
61_L 88_L 2.399 1.00
213_E 243_M 2.392 1.00
101_N 104_V 2.373 1.00
261_N 267_E 2.34 1.00
56_L 85_C 2.32 1.00
218_E 223_L 2.24 1.00
18_H 171_Y 2.116 0.99
264_T 267_E 2.097 0.99
151_F 181_I 2.073 0.99
79_T 82_A 2.039 0.99
218_E 240_K 2.034 0.99
243_M 263_Q 2.014 0.99
64_D 89_V 1.974 0.99
48_R 83_Y 1.964 0.99
47_A 58_F 1.883 0.98
20_I 132_F 1.852 0.98
8_H 196_Q 1.807 0.98
27_F 130_A 1.711 0.97
93_P 99_G 1.69 0.96
149_Y 173_G 1.688 0.96
222_M 284_V 1.687 0.96
90_H 126_Y 1.677 0.96
226_I 232_D 1.649 0.96
80_A 85_C 1.645 0.96
31_V 131_A 1.594 0.94
27_F 173_G 1.551 0.93
104_V 232_D 1.514 0.92
43_M 132_F 1.497 0.92
23_V 130_A 1.487 0.91
91_K 96_V 1.464 0.90
196_Q 273_L 1.458 0.90
31_V 122_A 1.455 0.90
95_G 114_M 1.455 0.90
78_R 204_D 1.445 0.90
232_D 239_I 1.433 0.89
29_N 127_G 1.431 0.89
270_E 274_V 1.427 0.89
79_T 83_Y 1.398 0.88
233_L 239_I 1.356 0.85
45_H 203_I 1.351 0.85
88_L 126_Y 1.349 0.85
42_V 194_I 1.328 0.84
233_L 236_G 1.327 0.84
90_H 122_A 1.326 0.84
217_L 226_I 1.31 0.83
79_T 85_C 1.302 0.82
175_I 181_I 1.296 0.82
66_G 91_K 1.295 0.82
55_T 86_E 1.288 0.81
93_P 96_V 1.281 0.81
210_L 265_L 1.255 0.79
48_R 56_L 1.252 0.78
124_N 155_F 1.252 0.78
66_G 99_G 1.25 0.78
239_I 243_M 1.249 0.78
82_A 204_D 1.248 0.78
123_L 131_A 1.237 0.77
93_P 118_G 1.236 0.77
56_L 84_G 1.223 0.76
54_G 149_Y 1.215 0.75
68_K 72_M 1.215 0.75
157_R 298_R 1.211 0.75
49_K 201_E 1.207 0.75
208_L 249_L 1.205 0.75
32_M 43_M 1.203 0.74
149_Y 183_V 1.199 0.74
123_L 180_S 1.199 0.74
217_L 239_I 1.199 0.74
15_E 188_N 1.191 0.73
256_G 284_V 1.191 0.73
60_L 167_L 1.186 0.73
26_E 149_Y 1.169 0.71
7_T 274_V 1.169 0.71
88_L 128_F 1.168 0.71
7_T 200_L 1.159 0.70
20_I 46_L 1.15 0.70
94_E 98_M 1.149 0.70
236_G 239_I 1.145 0.69
213_E 240_K 1.144 0.69
124_N 156_H 1.142 0.69
91_K 118_G 1.128 0.67
224_M 284_V 1.124 0.67
149_Y 153_D 1.119 0.67
59_P 88_L 1.117 0.66
217_L 252_W 1.117 0.66
238_V 242_R 1.107 0.65
216_V 244_V 1.106 0.65
215_P 239_I 1.101 0.65
266_P 270_E 1.101 0.65
95_G 118_G 1.095 0.64
6_L 14_A 1.075 0.62
205_I 210_L 1.074 0.62
222_M 256_G 1.068 0.61
151_F 180_S 1.065 0.61
48_R 79_T 1.064 0.61
23_V 27_F 1.052 0.60
95_G 113_I 1.048 0.59
36_I 206_V 1.046 0.59
223_L 259_E 1.04 0.58
215_P 236_G 1.036 0.58
24_A 27_F 1.034 0.58
70_R 74_E 1.032 0.57
219_R 236_G 1.023 0.56
220_D 287_R 1.022 0.56
224_M 242_R 1.022 0.56
199_W 269_I 1.007 0.55
117_E 284_V 1.007 0.55
63_V 90_H 1.005 0.54
151_F 175_I 1.003 0.54
63_V 118_G 1.002 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1zunA10.99671000.454Contact Map0.609
4bwvA20.76821000.741Contact Map0.749
2oq2A40.76161000.75Contact Map0.648
3fwkA10.71521000.775Contact Map0.538
2wsiA10.71521000.775Contact Map0.511
2goyA80.74831000.787Contact Map0.686
2o8vA10.71521000.794Contact Map0.64
1surA10.629199.90.822Contact Map0.697
2pg3A10.685499.70.874Contact Map0.54
3bl5A60.668999.70.877Contact Map0.668
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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