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OPENSEQ.org
FIC - Probable adenosine monophosphate-protein transferase fic
UniProt: P20605 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10307
Length: 200 (194)
Sequences: 509
Seq/Len: 2.62
FIC
Paralog alert: 0.07 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
43_R 68_Q 3.099 1.00
89_F 142_G 2.473 1.00
43_R 46_T 2.361 1.00
109_E 123_R 2.116 1.00
84_Q 139_V 2.074 1.00
142_G 146_R 2.024 1.00
132_N 142_G 2.007 0.99
129_C 177_G 2.002 0.99
139_V 143_L 1.866 0.99
62_I 147_I 1.862 0.99
36_A 71_F 1.82 0.99
43_R 69_D 1.779 0.98
56_L 99_G 1.692 0.98
24_L 35_A 1.688 0.98
89_F 132_N 1.672 0.97
128_Y 189_F 1.668 0.97
56_L 77_L 1.603 0.97
135_H 143_L 1.57 0.96
118_A 190_S 1.538 0.95
44_A 66_L 1.501 0.94
132_N 145_Q 1.49 0.94
122_E 186_Q 1.485 0.94
153_A 160_L 1.476 0.94
81_D 92_F 1.472 0.94
40_T 66_L 1.471 0.94
64_R 68_Q 1.468 0.94
147_I 150_E 1.453 0.93
24_L 39_M 1.449 0.93
109_E 127_Y 1.44 0.93
114_G 157_G 1.417 0.92
80_V 138_R 1.368 0.90
23_R 72_D 1.317 0.88
65_Q 68_Q 1.296 0.86
132_N 174_N 1.295 0.86
57_P 60_R 1.292 0.86
58_H 151_Q 1.292 0.86
89_F 135_H 1.287 0.86
84_Q 143_L 1.271 0.85
55_G 58_H 1.269 0.85
87_T 90_C 1.261 0.84
58_H 61_T 1.258 0.84
120_F 153_A 1.253 0.84
40_T 68_Q 1.25 0.84
59_L 161_S 1.224 0.82
60_R 77_L 1.218 0.81
176_S 184_A 1.211 0.81
128_Y 170_W 1.211 0.81
124_L 158_Y 1.209 0.81
93_A 168_E 1.19 0.79
28_Q 57_P 1.182 0.79
182_L 185_L 1.174 0.78
87_T 133_V 1.171 0.78
36_A 143_L 1.166 0.77
13_L 17_L 1.166 0.77
40_T 132_N 1.164 0.77
90_C 98_E 1.161 0.77
176_S 181_D 1.161 0.77
123_R 127_Y 1.151 0.76
138_R 143_L 1.149 0.76
67_Y 143_L 1.148 0.76
69_D 138_R 1.148 0.76
32_L 138_R 1.147 0.76
149_F 189_F 1.142 0.75
148_F 152_L 1.139 0.75
14_Y 18_D 1.137 0.75
28_Q 31_R 1.128 0.74
126_H 186_Q 1.127 0.74
169_A 191_K 1.126 0.74
163_Q 169_A 1.114 0.73
174_N 177_G 1.108 0.72
124_L 193_V 1.105 0.72
129_C 182_L 1.102 0.71
106_L 112_L 1.099 0.71
87_T 178_A 1.094 0.71
89_F 146_R 1.094 0.71
146_R 162_W 1.091 0.70
98_E 181_D 1.088 0.70
132_N 138_R 1.087 0.70
132_N 177_G 1.086 0.70
103_M 127_Y 1.085 0.70
128_Y 174_N 1.083 0.70
60_R 76_Q 1.083 0.70
65_Q 160_L 1.08 0.69
81_D 87_T 1.076 0.69
51_P 57_P 1.067 0.68
47_I 147_I 1.066 0.68
36_A 69_D 1.058 0.67
6_G 9_R 1.049 0.66
85_G 130_E 1.047 0.66
59_L 103_M 1.045 0.66
134_L 146_R 1.044 0.65
36_A 138_R 1.043 0.65
112_L 115_L 1.042 0.65
128_Y 142_G 1.039 0.65
109_E 112_L 1.036 0.65
89_F 171_N 1.034 0.64
46_T 68_Q 1.034 0.64
19_I 121_V 1.027 0.64
104_Q 108_E 1.026 0.63
128_Y 149_F 1.025 0.63
29_Q 33_E 1.011 0.62
18_D 27_R 1.006 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zc7A10.9951000.354Contact Map0.555
3shgA10.9951000.356Contact Map0.559
2jk8A211000.41Contact Map0.411
3se5A40.8151000.603Contact Map0.447
2f6sA20.8799.90.613Contact Map0.543
3zlmA10.8399.90.615Contact Map0.433
3n3uA10.93599.90.68Contact Map0.398
3cucA20.9899.90.688Contact Map0.495
2qc0A20.95599.60.749Contact Map0.401
3letA20.77599.50.768Contact Map0.392
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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