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OPENSEQ.org
ENTD - 4'-phosphopantetheinyl transferase EntD
UniProt: P19925 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10262
Length: 206 (196)
Sequences: 394
Seq/Len: 2.01
ENTD
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
53_G 88_I 4.522 1.00
89_S 96_L 2.88 1.00
89_S 108_I 2.833 1.00
149_S 153_S 2.63 1.00
73_G 77_Q 2.598 1.00
149_S 201_T 2.485 1.00
56_A 97_A 2.438 1.00
154_A 181_I 2.222 1.00
52_A 95_A 2.121 0.99
179_V 190_V 2.058 0.99
154_A 169_Y 1.943 0.99
150_A 179_V 1.851 0.98
70_P 99_V 1.844 0.98
159_E 169_Y 1.768 0.97
39_L 42_A 1.762 0.97
149_S 154_A 1.746 0.97
53_G 72_I 1.736 0.97
87_S 106_I 1.635 0.95
84_V 98_V 1.586 0.94
158_S 164_A 1.542 0.93
128_A 170_Q 1.537 0.92
30_L 36_Y 1.498 0.91
155_F 164_A 1.47 0.90
50_H 72_I 1.394 0.87
164_A 185_N 1.377 0.86
150_A 201_T 1.358 0.85
158_S 169_Y 1.358 0.85
154_A 158_S 1.347 0.84
30_L 33_L 1.333 0.83
125_I 147_A 1.312 0.82
96_L 108_I 1.308 0.81
52_A 61_L 1.296 0.81
42_A 133_L 1.296 0.81
170_Q 182_H 1.296 0.81
61_L 170_Q 1.293 0.80
61_L 84_V 1.289 0.80
161_Q 164_A 1.279 0.79
136_C 153_S 1.265 0.78
132_R 170_Q 1.242 0.77
87_S 98_V 1.236 0.76
88_I 165_G 1.223 0.75
39_L 52_A 1.215 0.74
38_Q 71_A 1.21 0.74
76_R 120_L 1.191 0.72
38_Q 44_R 1.189 0.72
120_L 124_I 1.184 0.72
76_R 192_W 1.183 0.71
27_E 47_K 1.182 0.71
38_Q 155_F 1.176 0.71
29_D 35_H 1.175 0.71
30_L 50_H 1.168 0.70
126_T 170_Q 1.164 0.70
72_I 88_I 1.162 0.69
182_H 187_M 1.162 0.69
72_I 76_R 1.149 0.68
77_Q 203_C 1.139 0.67
74_E 77_Q 1.137 0.67
185_N 188_F 1.125 0.66
159_E 164_A 1.123 0.66
91_C 106_I 1.121 0.65
53_G 95_A 1.119 0.65
98_V 193_Q 1.115 0.65
176_K 192_W 1.103 0.64
101_R 176_K 1.092 0.62
153_S 203_C 1.084 0.62
56_A 96_L 1.083 0.62
28_Q 33_L 1.083 0.62
49_E 76_R 1.079 0.61
88_I 149_S 1.077 0.61
66_Y 124_I 1.076 0.61
88_I 95_A 1.071 0.60
47_K 187_M 1.061 0.59
43_G 89_S 1.06 0.59
55_I 59_Y 1.055 0.59
98_V 124_I 1.052 0.58
93_T 159_E 1.052 0.58
132_R 168_D 1.051 0.58
190_V 203_C 1.048 0.58
60_A 99_V 1.042 0.57
19_E 24_N 1.029 0.56
45_K 49_E 1.025 0.55
111_I 174_W 1.022 0.55
51_L 200_I 1.02 0.55
85_Y 182_H 1.019 0.55
136_C 199_V 1.014 0.54
11_A 36_Y 1.009 0.53
24_N 28_Q 1.006 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qr0A10.912699.90.643Contact Map0.426
2c43A10.985499.90.659Contact Map0.461
3f09A30.635999.40.783Contact Map0.346
2wasA30.509799.10.808Contact Map0.478
3h88A240.514699.10.811Contact Map0.575
3hykA30.5146990.817Contact Map0.6
2wdsA10.5777990.818Contact Map0.586
1f7lA10.519498.80.829Contact Map0.608
1fthA30.514698.80.832Contact Map0.53
3gwmA10.514698.80.832Contact Map0.311
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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