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OPENSEQ.org
EUTC - Ethanolamine ammonia-lyase light chain
UniProt: P19636 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG50007
Length: 295 (249)
Sequences: 353
Seq/Len: 1.42
EUTC
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
166_S 205_G 3.349 1.00
202_V 209_I 3.246 1.00
215_E 249_A 2.74 1.00
251_T 255_D 2.714 1.00
214_G 246_P 2.549 1.00
177_N 269_P 2.362 0.99
161_V 223_I 2.339 0.99
221_V 280_A 2.325 0.99
210_E 224_L 2.279 0.99
240_C 262_I 2.255 0.99
123_V 202_V 2.247 0.99
110_V 175_T 2.19 0.99
210_E 222_V 2.155 0.99
202_V 205_G 2.144 0.99
174_I 238_L 2.095 0.98
160_D 220_K 2.045 0.98
164_V 222_V 1.961 0.97
59_E 81_G 1.935 0.97
240_C 259_I 1.934 0.97
244_Y 284_L 1.929 0.97
81_G 88_R 1.885 0.96
91_A 94_R 1.858 0.96
234_Q 263_H 1.814 0.95
162_Q 219_A 1.801 0.95
123_V 209_I 1.699 0.93
148_V 216_I 1.655 0.91
221_V 289_S 1.636 0.91
194_L 284_L 1.62 0.90
68_T 161_V 1.606 0.90
94_R 184_P 1.577 0.89
181_I 240_C 1.555 0.88
179_E 183_P 1.552 0.88
115_V 226_V 1.543 0.87
123_V 200_F 1.538 0.87
128_S 132_L 1.522 0.86
110_V 201_F 1.52 0.86
162_Q 197_G 1.52 0.86
244_Y 287_K 1.477 0.84
247_R 255_D 1.476 0.84
240_C 276_I 1.47 0.83
214_G 217_L 1.457 0.83
144_C 147_A 1.427 0.81
235_S 265_G 1.42 0.80
282_R 285_E 1.418 0.80
144_C 150_A 1.401 0.79
165_I 178_Y 1.391 0.79
112_E 201_F 1.389 0.78
71_R 124_R 1.353 0.76
117_A 222_V 1.348 0.75
124_R 144_C 1.324 0.74
163_V 185_L 1.285 0.70
67_L 78_V 1.281 0.70
129_D 204_Y 1.278 0.70
281_K 284_L 1.277 0.70
212_Q 249_A 1.253 0.68
280_A 284_L 1.234 0.66
194_L 280_A 1.22 0.65
196_V 218_G 1.218 0.64
177_N 271_E 1.212 0.64
252_V 255_D 1.21 0.64
161_V 280_A 1.206 0.63
130_K 204_Y 1.2 0.63
178_Y 182_L 1.196 0.62
127_I 204_Y 1.194 0.62
85_P 123_V 1.183 0.61
205_G 209_I 1.178 0.61
271_E 274_A 1.178 0.61
283_M 289_S 1.177 0.60
101_R 262_I 1.172 0.60
172_D 176_V 1.17 0.60
221_V 244_Y 1.169 0.60
126_E 148_V 1.169 0.60
212_Q 216_I 1.166 0.59
177_N 265_G 1.16 0.59
106_V 289_S 1.16 0.59
176_V 265_G 1.155 0.58
275_V 278_D 1.148 0.58
98_D 265_G 1.143 0.57
120_L 199_P 1.142 0.57
67_L 98_D 1.142 0.57
222_V 280_A 1.135 0.56
259_I 276_I 1.133 0.56
108_K 172_D 1.132 0.56
289_S 292_N 1.128 0.56
143_L 209_I 1.126 0.55
244_Y 275_V 1.117 0.54
221_V 284_L 1.113 0.54
83_A 165_I 1.107 0.53
93_L 104_D 1.106 0.53
71_R 164_V 1.089 0.52
112_E 116_K 1.086 0.51
203_R 209_I 1.086 0.51
282_R 286_Q 1.082 0.51
85_P 205_G 1.074 0.50
238_L 246_P 1.07 0.50
79_C 263_H 1.07 0.50
225_L 240_C 1.066 0.49
274_A 278_D 1.054 0.48
120_L 186_M 1.054 0.48
259_I 262_I 1.052 0.48
143_L 212_Q 1.041 0.47
176_V 188_G 1.033 0.46
132_L 145_A 1.031 0.46
71_R 165_I 1.03 0.46
91_A 96_L 1.028 0.45
181_I 185_L 1.027 0.45
112_E 203_R 1.021 0.45
128_S 149_E 1.018 0.44
85_P 202_V 1.013 0.44
166_S 224_L 1.013 0.44
278_D 289_S 1.006 0.43
172_D 216_I 1 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3abqB20.99661000.039Contact Map0.606
4narA10.5288170.975Contact Map0.492
2kkeA20.098314.30.976Contact Map0
1eexG20.467812.30.976Contact Map0.318
3otdA20.4983110.977Contact Map0.139
3kfuF20.2034100.977Contact Map
3ziaI20.12290.978Contact Map0.528
1ng6A10.17298.80.978Contact Map
2zktA20.43398.40.978Contact Map0.095
2ck3I10.12547.90.978Contact Map0.386
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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