| UniProt: | P18843 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10663 | ||
| Length: | 275 (251) | ||
| Sequences: | 2115 | ||
| Seq/Len: | 8.43 |
| NADE
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 203_E | 207_K | 4.673 | 1.00 | |
| 81_V | 149_I | 3.671 | 1.00 | |
| 60_C | 158_V | 3.461 | 1.00 | |
| 42_S | 155_G | 2.948 | 1.00 | |
| 253_N | 257_K | 2.812 | 1.00 | |
| 80_A | 103_P | 2.794 | 1.00 | |
| 23_I | 198_A | 2.611 | 1.00 | |
| 56_A | 184_L | 2.436 | 1.00 | |
| 55_L | 196_L | 2.341 | 1.00 | |
| 96_D | 204_H | 2.338 | 1.00 | |
| 95_Q | 99_A | 2.258 | 1.00 | |
| 88_Q | 92_Q | 2.177 | 1.00 | |
| 30_L | 59_L | 2.116 | 1.00 | |
| 57_G | 103_P | 2.05 | 1.00 | |
| 98_I | 106_V | 2.029 | 1.00 | |
| 245_Q | 249_R | 2.001 | 1.00 | |
| 34_L | 43_L | 1.99 | 1.00 | |
| 47_I | 98_I | 1.948 | 1.00 | |
| 46_G | 146_Q | 1.923 | 1.00 | |
| 112_K | 116_L | 1.92 | 1.00 | |
| 93_D | 208_K | 1.887 | 1.00 | |
| 51_Q | 196_L | 1.885 | 1.00 | |
| 37_Y | 156_V | 1.872 | 1.00 | |
| 118_S | 144_K | 1.869 | 1.00 | |
| 23_I | 62_M | 1.824 | 1.00 | |
| 19_A | 194_Q | 1.809 | 1.00 | |
| 20_E | 198_A | 1.794 | 1.00 | |
| 113_G | 120_Q | 1.767 | 1.00 | |
| 31_K | 66_E | 1.73 | 1.00 | |
| 118_S | 141_E | 1.714 | 1.00 | |
| 188_N | 191_Q | 1.711 | 1.00 | |
| 250_T | 254_W | 1.706 | 1.00 | |
| 259_E | 263_R | 1.705 | 1.00 | |
| 193_K | 232_D | 1.636 | 1.00 | |
| 194_Q | 197_A | 1.615 | 1.00 | |
| 116_L | 120_Q | 1.606 | 1.00 | |
| 149_I | 153_T | 1.605 | 1.00 | |
| 20_E | 24_R | 1.578 | 1.00 | |
| 54_T | 205_L | 1.561 | 1.00 | |
| 44_V | 149_I | 1.555 | 1.00 | |
| 51_Q | 206_Y | 1.541 | 1.00 | |
| 197_A | 203_E | 1.538 | 1.00 | |
| 173_K | 260_H | 1.525 | 1.00 | |
| 97_A | 205_L | 1.525 | 1.00 | |
| 236_D | 243_V | 1.507 | 1.00 | |
| 222_P | 225_V | 1.491 | 1.00 | |
| 79_I | 107_L | 1.49 | 1.00 | |
| 65_N | 71_T | 1.489 | 1.00 | |
| 59_L | 183_P | 1.489 | 1.00 | |
| 43_L | 60_C | 1.476 | 1.00 | |
| 137_E | 144_K | 1.46 | 0.99 | |
| 224_E | 230_T | 1.457 | 0.99 | |
| 69_L | 77_Q | 1.454 | 0.99 | |
| 96_D | 100_F | 1.451 | 0.99 | |
| 43_L | 64_I | 1.448 | 0.99 | |
| 24_R | 66_E | 1.447 | 0.99 | |
| 244_P | 247_V | 1.445 | 0.99 | |
| 230_T | 233_N | 1.441 | 0.99 | |
| 114_A | 121_A | 1.437 | 0.99 | |
| 96_D | 99_A | 1.424 | 0.99 | |
| 141_E | 144_K | 1.423 | 0.99 | |
| 82_R | 106_V | 1.394 | 0.99 | |
| 115_V | 141_E | 1.394 | 0.99 | |
| 57_G | 80_A | 1.392 | 0.99 | |
| 168_T | 234_I | 1.391 | 0.99 | |
| 95_Q | 106_V | 1.39 | 0.99 | |
| 236_D | 241_K | 1.382 | 0.99 | |
| 42_S | 77_Q | 1.378 | 0.99 | |
| 93_D | 204_H | 1.35 | 0.99 | |
| 33_Y | 36_T | 1.344 | 0.99 | |
| 89_A | 204_H | 1.338 | 0.99 | |
| 133_V | 148_S | 1.322 | 0.99 | |
| 171_F | 177_G | 1.311 | 0.99 | |
| 92_Q | 204_H | 1.301 | 0.98 | |
| 114_A | 145_A | 1.285 | 0.98 | |
| 73_N | 77_Q | 1.283 | 0.98 | |
| 212_A | 223_D | 1.262 | 0.98 | |
| 209_A | 222_P | 1.26 | 0.98 | |
| 233_N | 244_P | 1.254 | 0.98 | |
| 43_L | 158_V | 1.246 | 0.98 | |
| 254_W | 257_K | 1.244 | 0.98 | |
| 83_L | 157_V | 1.241 | 0.98 | |
| 210_P | 223_D | 1.241 | 0.98 | |
| 65_N | 68_R | 1.237 | 0.98 | |
| 197_A | 206_Y | 1.235 | 0.98 | |
| 238_L | 255_Y | 1.212 | 0.97 | |
| 28_D | 32_S | 1.21 | 0.97 | |
| 115_V | 119_E | 1.208 | 0.97 | |
| 182_N | 185_Y | 1.203 | 0.97 | |
| 92_Q | 96_D | 1.2 | 0.97 | |
| 34_L | 64_I | 1.197 | 0.97 | |
| 95_Q | 108_T | 1.195 | 0.97 | |
| 61_Q | 72_G | 1.191 | 0.97 | |
| 68_R | 104_D | 1.184 | 0.97 | |
| 159_G | 179_T | 1.18 | 0.97 | |
| 58_K | 62_M | 1.179 | 0.97 | |
| 82_R | 91_E | 1.167 | 0.96 | |
| 162_H | 223_D | 1.167 | 0.96 | |
| 79_I | 155_G | 1.166 | 0.96 | |
| 233_N | 247_V | 1.163 | 0.96 | |
| 30_L | 43_L | 1.142 | 0.96 | |
| 157_V | 260_H | 1.127 | 0.95 | |
| 179_T | 182_N | 1.127 | 0.95 | |
| 258_T | 262_R | 1.125 | 0.95 | |
| 159_G | 178_G | 1.124 | 0.95 | |
| 37_Y | 40_I | 1.118 | 0.95 | |
| 215_E | 226_A | 1.115 | 0.95 | |
| 57_G | 101_I | 1.11 | 0.95 | |
| 197_A | 207_K | 1.108 | 0.95 | |
| 173_K | 180_D | 1.104 | 0.95 | |
| 41_K | 154_S | 1.102 | 0.95 | |
| 168_T | 254_W | 1.095 | 0.94 | |
| 162_H | 210_P | 1.082 | 0.94 | |
| 161_D | 171_F | 1.072 | 0.93 | |
| 61_Q | 78_F | 1.072 | 0.93 | |
| 54_T | 97_A | 1.066 | 0.93 | |
| 114_A | 117_A | 1.06 | 0.93 | |
| 259_E | 262_R | 1.056 | 0.93 | |
| 24_R | 28_D | 1.054 | 0.93 | |
| 246_Q | 249_R | 1.05 | 0.93 | |
| 218_R | 221_L | 1.049 | 0.92 | |
| 95_Q | 98_I | 1.044 | 0.92 | |
| 61_Q | 101_I | 1.042 | 0.92 | |
| 107_L | 153_T | 1.041 | 0.92 | |
| 192_G | 196_L | 1.038 | 0.92 | |
| 193_K | 209_A | 1.035 | 0.92 | |
| 114_A | 141_E | 1.029 | 0.91 | |
| 163_A | 186_R | 1.023 | 0.91 | |
| 30_L | 181_I | 1.015 | 0.91 | |
| 62_M | 199_L | 1.014 | 0.91 | |
| 187_L | 191_Q | 1.013 | 0.91 | |
| 246_Q | 250_T | 1.012 | 0.91 | |
| 42_S | 79_I | 1.004 | 0.90 | |
| 141_E | 145_A | 1.003 | 0.90 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1wxiA | 1 | 0.9927 | 100 | 0.305 | Contact Map | 0.682 |
| 1kqpA | 2 | 0.9782 | 100 | 0.307 | Contact Map | 0.764 |
| 3dpiA | 2 | 0.9782 | 100 | 0.334 | Contact Map | 0.623 |
| 3q4gA | 2 | 0.96 | 100 | 0.339 | Contact Map | 0.727 |
| 3ilvA | 1 | 0.9673 | 100 | 0.405 | Contact Map | 0.644 |
| 4f4hA | 2 | 0.9455 | 100 | 0.432 | Contact Map | 0.779 |
| 3fiuA | 4 | 0.8873 | 100 | 0.433 | Contact Map | 0.794 |
| 1xngA | 2 | 0.8764 | 100 | 0.444 | Contact Map | 0.735 |
| 3n05A | 2 | 0.9273 | 100 | 0.448 | Contact Map | 0.696 |
| 3sdbA | 1 | 0.9745 | 100 | 0.452 | Contact Map | 0.67 |
Sequence Conservation (Image Generated using WebLogo v3)