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OPENSEQ.org
MINC - Septum site-determining protein MinC
UniProt: P18196 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10596
Length: 231 (231)
Sequences: 761
Seq/Len: 3.29
MINC
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
169_M 173_A 3.694 1.00
163_I 173_A 3.672 1.00
158_I 177_A 3.401 1.00
147_V 157_L 2.312 1.00
140_A 145_L 2.084 1.00
132_V 155_A 1.983 1.00
195_V 218_L 1.975 1.00
184_Q 217_R 1.863 0.99
218_L 225_L 1.812 0.99
166_Y 186_F 1.809 0.99
8_L 12_S 1.717 0.99
174_L 196_S 1.688 0.99
125_T 146_I 1.676 0.98
172_R 194_L 1.667 0.98
139_Y 160_D 1.666 0.98
150_H 195_V 1.631 0.98
33_E 71_T 1.571 0.97
160_D 178_S 1.534 0.97
132_V 138_I 1.493 0.96
33_E 37_A 1.471 0.96
60_N 63_A 1.446 0.95
134_S 169_M 1.4 0.94
157_L 165_V 1.393 0.94
197_I 225_L 1.379 0.93
219_Q 228_Q 1.377 0.93
194_L 203_L 1.373 0.93
107_R 111_T 1.372 0.93
172_R 193_E 1.368 0.93
141_P 160_D 1.368 0.93
35_K 39_A 1.356 0.93
194_L 201_Y 1.335 0.92
151_V 173_A 1.327 0.92
132_V 145_L 1.32 0.91
150_H 192_A 1.315 0.91
137_R 145_L 1.314 0.91
17_V 35_K 1.31 0.91
150_H 167_G 1.297 0.90
205_D 216_A 1.295 0.90
179_G 220_L 1.275 0.89
149_S 167_G 1.268 0.89
14_T 167_G 1.263 0.89
138_I 183_T 1.262 0.89
181_R 198_A 1.257 0.88
172_R 196_S 1.255 0.88
192_A 204_S 1.23 0.87
190_L 204_S 1.23 0.87
131_P 149_S 1.225 0.87
200_E 220_L 1.215 0.86
125_T 143_C 1.21 0.86
203_L 216_A 1.205 0.85
174_L 194_L 1.204 0.85
61_W 93_M 1.203 0.85
132_V 147_V 1.197 0.85
181_R 199_G 1.194 0.85
144_D 201_Y 1.194 0.85
63_A 67_A 1.184 0.84
10_G 14_T 1.179 0.84
49_V 156_E 1.179 0.84
8_L 36_I 1.172 0.83
5_P 31_A 1.167 0.83
196_S 203_L 1.161 0.82
48_V 71_T 1.159 0.82
140_A 160_D 1.159 0.82
135_G 152_S 1.15 0.82
196_S 199_G 1.147 0.81
77_G 225_L 1.144 0.81
15_L 49_V 1.134 0.80
158_I 165_V 1.132 0.80
126_R 143_C 1.126 0.80
61_W 90_I 1.122 0.79
63_A 66_K 1.119 0.79
108_P 112_P 1.119 0.79
42_F 190_L 1.118 0.79
150_H 168_M 1.112 0.79
180_D 198_A 1.104 0.78
187_C 192_A 1.1 0.78
74_R 96_P 1.09 0.77
188_T 192_A 1.089 0.77
185_I 195_V 1.086 0.76
201_Y 205_D 1.082 0.76
120_T 123_T 1.082 0.76
8_L 48_V 1.082 0.76
174_L 193_E 1.074 0.75
79_S 138_I 1.067 0.74
174_L 177_A 1.059 0.74
144_D 162_N 1.058 0.74
129_D 163_I 1.056 0.73
39_A 46_A 1.05 0.73
25_P 67_A 1.046 0.72
151_V 155_A 1.046 0.72
107_R 113_Q 1.043 0.72
10_G 17_V 1.04 0.72
187_C 190_L 1.04 0.72
88_A 91_E 1.037 0.71
151_V 157_L 1.036 0.71
144_D 164_H 1.036 0.71
199_G 220_L 1.032 0.71
26_K 30_Q 1.029 0.71
137_R 156_E 1.028 0.70
92_K 107_R 1.022 0.70
76_I 146_I 1.021 0.70
47_P 185_I 1.021 0.70
174_L 205_D 1.016 0.69
14_T 19_H 1.015 0.69
172_R 216_A 1.013 0.69
157_L 169_M 1.01 0.69
146_I 215_A 1.006 0.68
110_P 113_Q 1.005 0.68
126_R 140_A 1.005 0.68
221_V 226_T 1 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1hf2A40.86581000.123Contact Map0.545
3ghfA10.510899.70.697Contact Map0.435
2jwkA20.298730.30.947Contact Map0.456
2pfuA10.359327.30.948Contact Map0.318
2ipcA40.878819.80.951Contact Map0.083
1nktA20.792219.20.951Contact Map0.077
1pqsA10.28578.60.959Contact Map0.389
1uf2K10.268480.959Contact Map
4hhuA20.39395.90.962Contact Map0.011
1oeyA40.31174.40.964Contact Map0.262
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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