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OPENSEQ.org
MUTY - A/G-specific adenine glycosylase
UniProt: P17802 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10627
Length: 350 (341)
Sequences: 1361
Seq/Len: 3.99
MUTY
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
61_T 64_D 4.217 1.00
15_D 176_G 3.688 1.00
107_T 110_E 3.631 1.00
58_R 72_E 3.239 1.00
35_L 56_M 2.613 1.00
90_H 94_Q 2.557 1.00
58_R 76_L 2.502 1.00
150_A 209_I 2.482 1.00
247_A 260_C 2.463 1.00
215_S 219_Y 2.455 1.00
59_F 76_L 2.367 1.00
75_H 78_T 2.359 1.00
176_G 179_R 2.343 1.00
71_D 332_G 2.301 1.00
215_S 218_L 2.206 1.00
18_G 186_D 2.163 1.00
127_S 181_N 2.154 1.00
40_L 45_V 2.072 1.00
123_G 135_P 2.052 1.00
293_T 298_H 2.025 1.00
95_Q 115_P 2.023 1.00
106_E 132_K 1.984 1.00
250_P 253_G 1.968 1.00
21_T 26_I 1.903 1.00
53_E 57_A 1.902 1.00
108_F 134_F 1.892 1.00
11_L 179_R 1.874 1.00
15_D 179_R 1.854 1.00
29_T 32_K 1.835 1.00
150_A 219_Y 1.804 1.00
91_K 115_P 1.785 0.99
32_K 56_M 1.783 0.99
95_Q 99_L 1.782 0.99
14_Y 182_Q 1.781 0.99
27_D 33_V 1.779 0.99
6_F 204_L 1.776 0.99
52_F 56_M 1.773 0.99
111_V 126_L 1.771 0.99
84_A 88_N 1.763 0.99
209_I 213_N 1.739 0.99
9_Q 207_G 1.732 0.99
205_Q 211_A 1.699 0.99
104_F 111_V 1.689 0.99
324_N 327_Q 1.675 0.99
10_V 204_L 1.668 0.99
68_A 73_V 1.668 0.99
245_L 320_A 1.666 0.99
70_L 94_Q 1.65 0.99
148_C 207_G 1.641 0.99
100_H 113_A 1.626 0.99
95_Q 100_H 1.615 0.99
126_L 130_L 1.608 0.99
70_L 74_L 1.606 0.99
86_A 89_L 1.605 0.99
158_K 162_N 1.601 0.99
69_P 72_E 1.598 0.99
108_F 132_K 1.589 0.98
149_Y 167_L 1.587 0.98
29_T 33_V 1.587 0.98
11_L 15_D 1.582 0.98
198_K 201_L 1.582 0.98
63_T 67_N 1.58 0.98
119_R 165_W 1.58 0.98
92_A 114_L 1.566 0.98
62_V 104_F 1.562 0.98
239_Q 305_W 1.553 0.98
229_P 297_F 1.546 0.98
237_L 340_L 1.543 0.98
100_H 110_E 1.541 0.98
334_A 337_V 1.525 0.98
126_L 132_K 1.522 0.98
50_P 53_E 1.51 0.98
150_A 213_N 1.505 0.98
240_H 243_E 1.498 0.98
153_G 160_V 1.485 0.97
11_L 176_G 1.484 0.97
108_F 112_A 1.477 0.97
11_L 183_A 1.468 0.97
7_S 173_P 1.467 0.97
151_V 167_L 1.463 0.97
136_I 165_W 1.451 0.97
216_W 219_Y 1.448 0.97
230_E 300_D 1.445 0.97
186_D 190_M 1.438 0.97
250_P 256_G 1.431 0.96
96_V 104_F 1.416 0.96
70_L 90_H 1.414 0.96
148_C 204_L 1.407 0.96
39_M 48_V 1.397 0.96
335_A 338_E 1.39 0.96
153_G 163_K 1.39 0.96
63_T 97_A 1.389 0.96
192_C 199_C 1.388 0.96
180_F 184_M 1.382 0.95
86_A 90_H 1.373 0.95
199_C 208_C 1.368 0.95
65_L 73_V 1.358 0.95
199_C 202_C 1.345 0.95
103_K 106_E 1.343 0.94
35_L 89_L 1.34 0.94
158_K 161_E 1.34 0.94
246_L 331_V 1.336 0.94
10_V 184_M 1.332 0.94
88_N 91_K 1.329 0.94
202_C 208_C 1.321 0.94
126_L 134_F 1.32 0.94
323_Y 331_V 1.315 0.94
135_P 172_T 1.308 0.93
10_V 183_A 1.305 0.93
192_C 202_C 1.3 0.93
44_Q 47_T 1.293 0.93
73_V 90_H 1.287 0.93
249_R 253_G 1.275 0.92
120_S 137_L 1.265 0.92
112_A 119_R 1.259 0.92
235_F 301_I 1.252 0.91
62_V 96_V 1.25 0.91
14_Y 25_Q 1.249 0.91
34_W 38_V 1.245 0.91
291_R 300_D 1.231 0.90
137_L 164_L 1.231 0.90
168_S 180_F 1.23 0.90
246_L 333_L 1.221 0.90
49_I 53_E 1.22 0.90
303_P 340_L 1.209 0.89
27_D 32_K 1.201 0.89
117_V 125_I 1.199 0.89
228_L 298_H 1.198 0.89
10_V 187_L 1.196 0.89
231_R 297_F 1.194 0.88
92_A 95_Q 1.176 0.87
145_L 184_M 1.175 0.87
134_F 169_E 1.173 0.87
173_P 177_V 1.171 0.87
135_P 169_E 1.166 0.87
179_R 183_A 1.164 0.87
178_E 183_A 1.159 0.86
145_L 171_V 1.142 0.85
150_A 215_S 1.139 0.85
301_I 336_P 1.138 0.85
94_Q 98_T 1.135 0.85
222_K 225_K 1.134 0.85
172_T 184_M 1.131 0.85
209_I 212_A 1.13 0.84
96_V 111_V 1.129 0.84
152_S 221_G 1.127 0.84
255_W 294_F 1.125 0.84
211_A 216_W 1.118 0.84
291_R 298_H 1.108 0.83
155_P 158_K 1.101 0.82
192_C 208_C 1.097 0.82
120_S 136_I 1.096 0.82
327_Q 330_S 1.096 0.82
210_A 216_W 1.095 0.82
67_N 97_A 1.094 0.82
111_V 134_F 1.088 0.81
254_L 294_F 1.087 0.81
91_K 94_Q 1.086 0.81
136_I 141_V 1.077 0.80
232_T 300_D 1.068 0.80
146_A 164_L 1.055 0.78
73_V 86_A 1.054 0.78
46_A 49_I 1.053 0.78
128_L 178_E 1.052 0.78
239_Q 307_P 1.049 0.78
260_C 263_Q 1.047 0.78
39_M 253_G 1.042 0.77
152_S 219_Y 1.039 0.77
59_F 90_H 1.038 0.77
22_L 45_V 1.034 0.76
259_Y 322_W 1.034 0.76
156_G 223_K 1.023 0.75
177_V 181_N 1.018 0.75
131_G 178_E 1.018 0.75
59_F 72_E 1.013 0.74
186_D 189_A 1.012 0.74
111_V 125_I 1.011 0.74
39_M 47_T 1.011 0.74
167_L 170_Q 1.011 0.74
234_Y 304_M 1.009 0.74
24_W 40_L 1.009 0.74
70_L 248_Q 1.007 0.74
38_V 125_I 1.006 0.74
24_W 48_V 1.003 0.73
187_L 203_P 1.002 0.73
25_Q 120_S 1.001 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fspA10.99141000.411Contact Map0.69
1kg2A10.64291000.538Contact Map0.713
3n5nX20.721000.55Contact Map0.699
1keaA10.61141000.599Contact Map0.683
1ornA10.62291000.635Contact Map0.618
2abkA10.59141000.652Contact Map0.619
1pu6A20.53431000.748Contact Map0.503
3n0uA30.54291000.75Contact Map0.412
3fhfA10.54291000.762Contact Map0.418
2h56A30.51141000.765Contact Map0.464
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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