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MURG - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
UniProt: P17443 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10623
Length: 355 (347)
Sequences: 6667
Seq/Len: 19.21
MURG
Paralog alert: 0.39 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_R 35_Q 3.826 1.00
295_L 301_A 3.538 1.00
10_V 26_A 3.085 1.00
328_T 331_E 2.819 1.00
32_Q 347_N 2.684 1.00
88_R 116_S 2.635 1.00
293_L 297_K 2.511 1.00
207_K 315_A 2.449 1.00
28_H 31_A 2.44 1.00
9_M 91_M 2.398 1.00
37_R 58_D 2.342 1.00
47_A 51_P 2.316 1.00
261_S 278_F 2.282 1.00
7_R 37_R 2.206 1.00
340_D 344_R 2.202 1.00
28_H 343_E 2.192 1.00
9_M 39_L 2.19 1.00
257_V 269_I 2.168 1.00
296_E 303_I 2.094 1.00
28_H 32_Q 2.074 1.00
277_L 321_W 2.021 1.00
37_R 94_Y 2.021 1.00
35_Q 56_E 1.994 1.00
246_D 249_A 1.963 1.00
29_L 346_A 1.951 1.00
184_R 213_T 1.947 1.00
203_Q 311_V 1.94 1.00
34_W 350_S 1.932 1.00
257_V 274_L 1.928 1.00
256_V 321_W 1.927 1.00
313_A 317_T 1.893 1.00
344_R 347_N 1.889 1.00
327_L 331_E 1.882 1.00
185_V 256_V 1.878 1.00
32_Q 350_S 1.857 1.00
315_A 319_A 1.852 1.00
320_G 325_T 1.846 1.00
269_I 276_A 1.841 1.00
328_T 332_R 1.841 1.00
266_V 295_L 1.816 1.00
286_R 289_Y 1.796 1.00
101_G 121_V 1.789 1.00
10_V 100_L 1.786 1.00
342_T 346_A 1.785 1.00
61_R 86_Q 1.767 1.00
259_C 276_A 1.757 1.00
305_E 308_Q 1.74 1.00
27_H 55_I 1.734 1.00
89_A 93_A 1.719 1.00
25_V 345_V 1.709 1.00
8_L 34_W 1.707 1.00
332_R 335_A 1.691 1.00
8_L 29_L 1.664 1.00
277_L 302_K 1.657 1.00
324_E 327_L 1.652 1.00
88_R 117_L 1.651 1.00
179_R 213_T 1.628 1.00
92_K 117_L 1.626 1.00
185_V 258_V 1.623 1.00
17_G 21_P 1.616 1.00
348_E 351_R 1.61 1.00
330_A 333_A 1.587 1.00
28_H 342_T 1.568 1.00
289_Y 293_L 1.561 1.00
111_G 121_V 1.554 1.00
326_L 330_A 1.554 1.00
338_I 344_R 1.55 1.00
302_K 317_T 1.532 1.00
145_M 345_V 1.519 1.00
207_K 312_D 1.515 1.00
8_L 98_V 1.501 1.00
122_V 349_V 1.484 1.00
9_M 96_P 1.478 1.00
289_Y 305_E 1.47 1.00
329_M 332_R 1.467 1.00
206_A 232_E 1.459 1.00
99_V 114_A 1.457 1.00
48_D 52_K 1.457 1.00
316_N 320_G 1.453 1.00
29_L 34_W 1.452 1.00
270_A 300_A 1.448 1.00
184_R 215_W 1.447 1.00
256_V 318_L 1.437 1.00
325_T 328_T 1.416 1.00
58_D 93_A 1.416 1.00
302_K 321_W 1.402 0.99
302_K 320_G 1.4 0.99
199_Q 203_Q 1.396 0.99
277_L 317_T 1.393 0.99
20_F 243_F 1.39 0.99
293_L 296_E 1.387 0.99
294_P 297_K 1.38 0.99
25_V 100_L 1.371 0.99
343_E 347_N 1.366 0.99
182_P 213_T 1.362 0.99
212_V 319_A 1.357 0.99
310_S 313_A 1.356 0.99
257_V 265_T 1.352 0.99
204_V 314_V 1.346 0.99
188_V 247_M 1.323 0.99
215_W 250_A 1.309 0.99
122_V 352_V 1.309 0.99
89_A 92_K 1.303 0.99
7_R 97_D 1.302 0.99
86_Q 89_A 1.29 0.99
186_L 254_A 1.286 0.99
82_N 86_Q 1.284 0.99
26_A 55_I 1.277 0.99
195_R 199_Q 1.272 0.99
273_G 334_R 1.266 0.99
224_Q 228_Q 1.266 0.99
10_V 29_L 1.263 0.99
313_A 316_N 1.258 0.99
98_V 122_V 1.252 0.99
183_V 255_D 1.252 0.99
347_N 351_R 1.248 0.99
205_A 214_I 1.248 0.99
30_M 36_V 1.239 0.98
30_M 55_I 1.239 0.98
11_M 110_G 1.237 0.98
27_H 30_M 1.232 0.98
282_Q 286_R 1.229 0.98
344_R 348_E 1.228 0.98
7_R 94_Y 1.225 0.98
311_V 315_A 1.225 0.98
42_A 59_F 1.217 0.98
220_K 242_E 1.205 0.98
312_D 316_N 1.192 0.98
101_G 110_G 1.191 0.98
333_A 337_S 1.189 0.98
208_L 212_V 1.188 0.98
204_V 318_L 1.188 0.98
252_A 272_A 1.186 0.98
185_V 214_I 1.182 0.98
10_V 22_G 1.174 0.98
280_P 292_A 1.17 0.97
28_H 346_A 1.166 0.97
88_R 92_K 1.165 0.97
259_C 265_T 1.164 0.97
278_F 292_A 1.163 0.97
115_W 118_G 1.161 0.97
85_R 89_A 1.16 0.97
84_W 88_R 1.156 0.97
278_F 295_L 1.143 0.97
16_G 20_F 1.137 0.97
28_H 347_N 1.136 0.97
145_M 348_E 1.136 0.97
346_A 350_S 1.135 0.97
203_Q 206_A 1.134 0.97
299_G 328_T 1.131 0.97
278_F 301_A 1.113 0.96
178_G 184_R 1.113 0.96
186_L 251_Y 1.104 0.96
325_T 329_M 1.097 0.96
182_P 211_S 1.094 0.96
331_E 334_R 1.09 0.96
323_R 327_L 1.088 0.96
22_G 102_M 1.079 0.95
130_A 195_R 1.077 0.95
204_V 315_A 1.075 0.95
322_S 325_T 1.075 0.95
331_E 335_A 1.067 0.95
27_H 165_D 1.061 0.95
215_W 239_K 1.059 0.95
40_G 45_M 1.052 0.95
308_Q 313_A 1.051 0.94
98_V 349_V 1.05 0.94
183_V 323_R 1.047 0.94
317_T 320_G 1.041 0.94
340_D 343_E 1.034 0.94
186_L 217_Q 1.034 0.94
42_A 61_R 1.033 0.94
330_A 334_R 1.032 0.94
124_H 161_P 1.031 0.94
84_W 112_L 1.025 0.93
269_I 278_F 1.024 0.93
84_W 113_A 1.022 0.93
10_V 36_V 1.022 0.93
6_K 34_W 1.013 0.93
200_T 311_V 1.01 0.93
178_G 213_T 1.009 0.93
244_I 250_A 1.007 0.93
122_V 143_K 1.004 0.93
290_W 293_L 1.002 0.92
207_K 311_V 1.002 0.92
34_W 97_D 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ia7A20.94651000.307Contact Map0.724
3rscA20.94931000.323Contact Map0.686
2iyfA20.94931000.343Contact Map0.725
3otiA20.94371000.353Contact Map0.686
2p6pA20.93521000.358Contact Map0.742
3tsaA20.94651000.358Contact Map0.686
2acvA20.9691000.359Contact Map0.693
4fzrA10.94931000.359Contact Map0.715
1f0kA20.99721000.36Contact Map0.761
2iyaA20.94651000.364Contact Map0.74
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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