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OPENSEQ.org
PTQC - N,N'-diacetylchitobiose permease IIC component
UniProt: P17334 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10141
Length: 452 (423)
Sequences: 1073
Seq/Len: 2.54
PTQC
Paralog alert: 0.63 [within 20: 0.25] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
100_F 118_G 4.361 1.00
310_T 342_N 3.856 1.00
381_I 411_V 3.789 1.00
371_I 418_I 3.296 1.00
312_G 419_A 3.169 1.00
321_S 431_N 2.877 1.00
367_I 422_I 2.72 1.00
382_P 405_S 2.549 1.00
102_I 153_I 2.525 1.00
314_I 345_I 2.486 1.00
246_F 358_F 2.454 1.00
99_P 121_S 2.427 1.00
95_S 152_G 2.332 1.00
368_L 415_N 2.312 1.00
110_R 164_T 2.298 1.00
368_L 419_A 2.292 1.00
372_T 376_Y 2.225 1.00
24_H 106_L 2.18 1.00
371_I 411_V 2.062 1.00
261_G 265_P 2.06 1.00
364_V 367_I 2.034 1.00
24_H 161_E 2.012 0.99
398_A 412_A 1.975 0.99
417_G 421_L 1.972 0.99
110_R 161_E 1.945 0.99
380_I 411_V 1.933 0.99
207_L 217_I 1.928 0.99
364_V 422_I 1.908 0.99
231_S 291_H 1.906 0.99
23_P 109_E 1.901 0.99
361_F 423_Y 1.838 0.99
421_L 424_L 1.831 0.99
233_V 370_A 1.827 0.99
249_I 254_A 1.795 0.98
357_M 430_A 1.793 0.98
372_T 415_N 1.783 0.98
103_G 117_A 1.763 0.98
316_A 427_V 1.754 0.98
375_A 380_I 1.75 0.98
176_P 179_V 1.742 0.98
326_Y 430_A 1.726 0.98
166_I 195_I 1.703 0.98
107_A 117_A 1.692 0.98
316_A 420_T 1.69 0.98
165_F 169_R 1.686 0.97
315_L 416_L 1.684 0.97
398_A 408_A 1.672 0.97
270_N 274_Y 1.665 0.97
161_E 164_T 1.662 0.97
124_A 196_I 1.658 0.97
367_I 418_I 1.641 0.97
9_E 14_P 1.624 0.97
245_W 251_G 1.623 0.97
397_G 412_A 1.618 0.97
23_P 110_R 1.609 0.96
268_L 272_A 1.593 0.96
31_G 101_F 1.582 0.96
22_Q 161_E 1.572 0.96
406_V 410_L 1.568 0.96
411_V 415_N 1.565 0.96
106_L 110_R 1.555 0.95
238_V 366_P 1.555 0.95
306_G 310_T 1.55 0.95
414_F 418_I 1.547 0.95
405_S 408_A 1.541 0.95
106_L 161_E 1.537 0.95
321_S 427_V 1.519 0.95
337_G 342_N 1.516 0.94
312_G 416_L 1.514 0.94
314_I 317_I 1.508 0.94
402_T 408_A 1.504 0.94
375_A 381_I 1.476 0.93
310_T 337_G 1.474 0.93
323_R 431_N 1.467 0.93
103_G 118_G 1.465 0.93
294_A 384_V 1.454 0.93
399_F 409_L 1.429 0.92
430_A 434_Q 1.429 0.92
305_G 308_G 1.428 0.92
7_S 11_V 1.424 0.92
324_A 328_Q 1.418 0.92
164_T 168_R 1.413 0.91
413_L 417_G 1.408 0.91
264_T 268_L 1.405 0.91
156_G 160_A 1.403 0.91
295_K 299_D 1.402 0.91
98_A 102_I 1.402 0.91
414_F 417_G 1.402 0.91
274_Y 283_A 1.401 0.91
202_I 206_A 1.394 0.91
374_A 378_M 1.384 0.90
273_T 290_F 1.384 0.90
100_F 122_V 1.383 0.90
382_P 407_A 1.359 0.89
327_R 331_K 1.357 0.89
128_V 155_I 1.351 0.89
232_V 235_W 1.344 0.88
113_D 185_R 1.34 0.88
316_A 424_L 1.331 0.88
371_I 375_A 1.329 0.88
175_L 179_V 1.317 0.87
89_G 126_M 1.305 0.86
415_N 419_A 1.302 0.86
305_G 311_L 1.301 0.86
395_G 409_L 1.3 0.86
364_V 419_A 1.286 0.85
162_M 196_I 1.277 0.85
309_A 368_L 1.277 0.85
99_P 118_G 1.276 0.85
269_E 291_H 1.274 0.84
243_L 247_F 1.273 0.84
375_A 411_V 1.269 0.84
125_F 152_G 1.262 0.84
152_G 156_G 1.261 0.84
312_G 420_T 1.244 0.82
305_G 342_N 1.242 0.82
24_H 110_R 1.241 0.82
363_L 367_I 1.24 0.82
252_A 307_S 1.239 0.82
373_L 377_Y 1.236 0.82
346_L 361_F 1.23 0.81
337_G 345_I 1.228 0.81
28_I 157_L 1.227 0.81
270_N 273_T 1.226 0.81
274_Y 290_F 1.215 0.80
316_A 319_I 1.214 0.80
370_A 374_A 1.212 0.80
315_L 420_T 1.207 0.80
308_G 365_Q 1.207 0.80
342_N 346_L 1.198 0.79
175_L 178_S 1.197 0.79
418_I 422_I 1.197 0.79
306_G 342_N 1.196 0.79
267_A 270_N 1.193 0.79
40_L 190_L 1.19 0.78
308_G 342_N 1.188 0.78
330_A 427_V 1.185 0.78
219_M 223_S 1.183 0.78
24_H 157_L 1.183 0.78
416_L 420_T 1.178 0.77
346_L 351_I 1.178 0.77
395_G 412_A 1.175 0.77
120_L 193_G 1.174 0.77
308_G 423_Y 1.171 0.77
38_L 97_M 1.165 0.76
316_A 330_A 1.162 0.76
99_P 152_G 1.161 0.76
124_A 200_M 1.159 0.76
420_T 424_L 1.154 0.75
172_V 188_S 1.147 0.75
238_V 370_A 1.146 0.75
372_T 411_V 1.143 0.74
103_G 121_S 1.143 0.74
301_F 376_Y 1.142 0.74
267_A 271_I 1.138 0.74
313_L 427_V 1.131 0.73
50_N 84_G 1.13 0.73
191_I 195_I 1.128 0.73
158_V 199_V 1.128 0.73
31_G 157_L 1.125 0.73
364_V 418_I 1.123 0.73
35_L 98_A 1.118 0.72
99_P 156_G 1.116 0.72
395_G 413_L 1.113 0.72
315_L 338_I 1.106 0.71
384_V 402_T 1.098 0.70
34_R 101_F 1.094 0.70
428_V 431_N 1.088 0.69
380_I 407_A 1.087 0.69
123_A 197_L 1.083 0.69
128_V 433_A 1.076 0.68
351_I 357_M 1.075 0.68
181_A 332_L 1.072 0.67
317_I 345_I 1.065 0.67
367_I 371_I 1.06 0.66
320_A 424_L 1.06 0.66
411_V 414_F 1.06 0.66
392_M 400_F 1.058 0.66
175_L 187_F 1.056 0.66
129_T 215_H 1.056 0.66
213_N 216_Q 1.056 0.66
394_T 416_L 1.054 0.66
235_W 239_I 1.051 0.65
8_L 12_L 1.05 0.65
6_A 10_K 1.049 0.65
301_F 402_T 1.035 0.63
49_N 83_G 1.035 0.63
371_I 415_N 1.033 0.63
23_P 27_A 1.033 0.63
317_I 427_V 1.032 0.63
318_F 331_K 1.032 0.63
3_N 7_S 1.03 0.63
356_V 429_V 1.029 0.63
173_I 179_V 1.025 0.62
173_I 176_P 1.02 0.62
358_F 362_V 1.015 0.61
86_V 201_G 1.011 0.61
87_Y 92_G 1.01 0.61
395_G 398_A 1.01 0.61
317_I 349_L 1.01 0.61
270_N 283_A 1.002 0.60
394_T 412_A 1 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qnqA40.93581000.34Contact Map0.799
3mk7C40.22797.80.98Contact Map0.275
2kncB10.1355.30.981Contact Map0.514
2m7gA10.10844.50.982Contact Map0.273
1psmA10.05534.10.982Contact Map0.383
1oqwA20.108440.982Contact Map0.553
2kncA10.1153.80.983Contact Map0.243
3zwhQ10.05093.40.983Contact Map0
3tj6B10.03543.40.983Contact Map
4ev6A50.18583.20.983Contact Map0.243
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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