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OPENSEQ.org
MOEA - Molybdopterin molybdenumtransferase
UniProt: P12281 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10153
Length: 411 (401)
Sequences: 2542
Seq/Len: 6.34
MOEA
Paralog alert: 0.34 [within 20: 0.06] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
104_V 136_I 4.121 1.00
181_A 244_A 3.885 1.00
213_L 218_C 3.629 1.00
28_E 38_R 3.395 1.00
164_I 172_V 3.378 1.00
42_S 173_P 3.108 1.00
157_T 160_E 3.04 1.00
234_R 267_E 2.93 1.00
154_T 160_E 2.85 1.00
91_P 94_T 2.739 1.00
75_P 94_T 2.692 1.00
332_R 400_E 2.681 1.00
54_D 138_R 2.646 1.00
64_R 67_D 2.592 1.00
29_T 171_E 2.588 1.00
338_R 394_E 2.524 1.00
49_D 139_R 2.506 1.00
43_D 151_P 2.463 1.00
332_R 398_W 2.434 1.00
333_V 401_V 2.356 1.00
295_C 312_V 2.348 1.00
346_L 388_R 2.273 1.00
54_D 139_R 2.254 1.00
45_V 148_V 2.247 1.00
40_L 150_F 2.209 1.00
335_T 393_V 2.128 1.00
149_V 167_L 2.109 1.00
346_L 385_V 2.077 1.00
351_G 382_C 2.066 1.00
276_L 311_L 2.044 1.00
338_R 395_V 2.035 1.00
394_E 397_E 2.015 1.00
246_V 316_L 2.009 1.00
55_N 137_R 2.009 1.00
32_L 165_A 2.003 1.00
230_P 264_I 1.984 1.00
43_D 152_A 1.944 1.00
308_F 312_V 1.941 1.00
43_D 148_V 1.905 1.00
62_A 108_C 1.89 1.00
239_E 243_Q 1.86 1.00
49_D 145_A 1.844 1.00
63_V 110_A 1.8 1.00
29_T 173_P 1.775 1.00
118_E 125_R 1.762 1.00
78_G 96_I 1.758 1.00
221_I 244_A 1.755 1.00
162_P 208_A 1.751 1.00
334_R 360_E 1.75 1.00
248_I 312_V 1.747 1.00
351_G 384_I 1.742 1.00
197_G 200_Q 1.727 1.00
65_L 110_A 1.703 1.00
73_P 125_R 1.683 1.00
65_L 109_E 1.667 1.00
77_A 94_T 1.642 1.00
89_E 106_E 1.641 1.00
179_R 219_E 1.64 1.00
49_D 144_S 1.638 1.00
382_C 401_V 1.634 1.00
10_L 348_F 1.628 1.00
230_P 263_T 1.626 1.00
306_L 383_F 1.624 1.00
213_L 220_V 1.614 1.00
177_K 219_E 1.598 1.00
144_S 147_A 1.592 1.00
117_T 124_V 1.591 1.00
31_P 34_Q 1.587 0.99
182_L 210_H 1.581 0.99
156_L 160_E 1.578 0.99
113_M 116_Q 1.574 0.99
30_L 38_R 1.573 0.99
15_N 19_S 1.567 0.99
53_F 103_P 1.559 0.99
81_F 258_A 1.556 0.99
227_R 232_A 1.553 0.99
270_E 288_K 1.536 0.99
223_L 243_Q 1.535 0.99
305_T 377_F 1.531 0.99
190_Q 200_Q 1.53 0.99
114_Q 255_V 1.521 0.99
34_Q 214_E 1.517 0.99
47_P 167_L 1.486 0.99
26_A 176_R 1.482 0.99
278_I 311_L 1.48 0.99
313_Q 317_A 1.48 0.99
10_L 311_L 1.449 0.99
181_A 223_L 1.447 0.99
161_L 211_L 1.43 0.99
21_V 315_L 1.416 0.99
78_G 86_Y 1.412 0.99
216_L 308_F 1.406 0.98
206_R 222_N 1.402 0.98
295_C 315_L 1.397 0.98
156_L 161_L 1.391 0.98
47_P 169_I 1.379 0.98
112_V 126_F 1.373 0.98
150_F 160_E 1.371 0.98
330_R 400_E 1.363 0.98
9_S 12_T 1.361 0.98
286_F 295_C 1.353 0.98
44_V 164_I 1.347 0.98
352_V 381_N 1.339 0.98
30_L 35_C 1.338 0.98
113_M 135_N 1.335 0.98
98_I 102_A 1.334 0.98
90_W 108_C 1.33 0.98
48_L 202_Y 1.33 0.98
52_G 201_I 1.327 0.98
351_G 363_V 1.32 0.97
193_G 202_Y 1.32 0.97
212_M 308_F 1.312 0.97
64_R 109_E 1.307 0.97
192_P 207_L 1.305 0.97
8_M 13_A 1.305 0.97
18_L 318_K 1.305 0.97
65_L 132_S 1.29 0.97
112_V 117_T 1.289 0.97
384_I 399_V 1.286 0.97
97_R 114_Q 1.271 0.97
27_Q 173_P 1.269 0.97
148_V 151_P 1.268 0.97
141_E 370_G 1.262 0.96
111_V 135_N 1.261 0.96
363_V 382_C 1.26 0.96
58_M 135_N 1.241 0.96
333_V 363_V 1.24 0.96
57_A 137_R 1.234 0.96
334_R 398_W 1.234 0.96
353_L 401_V 1.232 0.96
390_R 397_E 1.226 0.96
383_F 404_F 1.224 0.96
184_S 224_G 1.224 0.96
249_S 294_F 1.222 0.95
17_M 286_F 1.218 0.95
54_D 106_E 1.207 0.95
142_D 302_V 1.206 0.95
223_L 240_A 1.206 0.95
246_V 295_C 1.202 0.95
265_L 294_F 1.196 0.95
117_T 126_F 1.191 0.95
183_F 226_I 1.19 0.95
12_T 16_E 1.189 0.95
183_F 236_A 1.187 0.94
12_T 15_N 1.183 0.94
229_D 232_A 1.183 0.94
208_A 305_T 1.174 0.94
161_L 207_L 1.171 0.94
234_R 238_I 1.169 0.94
254_S 283_P 1.165 0.94
285_A 296_G 1.161 0.94
39_I 155_R 1.156 0.93
333_V 353_L 1.151 0.93
226_I 232_A 1.148 0.93
182_L 220_V 1.148 0.93
196_L 199_G 1.145 0.93
184_S 250_S 1.145 0.93
282_K 303_S 1.137 0.93
344_G 389_D 1.135 0.93
230_P 267_E 1.13 0.92
66_A 109_E 1.13 0.92
79_K 258_A 1.129 0.92
151_P 154_T 1.124 0.92
10_L 278_I 1.122 0.92
36_F 161_L 1.119 0.92
232_A 235_A 1.117 0.92
284_F 311_L 1.116 0.92
310_Q 402_E 1.113 0.92
99_M 258_A 1.113 0.92
223_L 244_A 1.113 0.92
226_I 236_A 1.106 0.91
182_L 213_L 1.105 0.91
104_V 111_V 1.103 0.91
190_Q 196_L 1.102 0.91
353_L 381_N 1.101 0.91
147_A 375_S 1.095 0.91
181_A 243_Q 1.09 0.90
138_R 141_E 1.089 0.90
79_K 257_E 1.084 0.90
184_S 203_D 1.078 0.90
212_M 309_Y 1.077 0.90
298_P 303_S 1.077 0.90
196_L 202_Y 1.075 0.90
118_E 127_T 1.073 0.90
235_A 239_E 1.073 0.90
348_F 385_V 1.072 0.89
67_D 93_G 1.07 0.89
262_K 274_W 1.07 0.89
80_S 86_Y 1.068 0.89
28_E 176_R 1.067 0.89
57_A 141_E 1.065 0.89
183_F 247_V 1.062 0.89
36_F 214_E 1.06 0.89
241_D 292_S 1.056 0.89
20_R 286_F 1.056 0.89
210_H 214_E 1.051 0.88
80_S 96_I 1.05 0.88
35_C 156_L 1.049 0.88
331_Q 403_P 1.049 0.88
265_L 287_G 1.048 0.88
46_S 167_L 1.039 0.87
213_L 308_F 1.032 0.87
58_M 113_M 1.026 0.87
203_D 206_R 1.025 0.86
279_K 347_D 1.025 0.86
97_R 257_E 1.023 0.86
234_R 268_L 1.023 0.86
110_A 130_V 1.02 0.86
212_M 305_T 1.016 0.86
181_A 247_V 1.016 0.86
84_Q 187_D 1.012 0.86
335_T 339_L 1.01 0.85
237_F 247_V 1.005 0.85
162_P 374_F 1.003 0.85
8_M 16_E 1.002 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1g8lA211000.092Contact Map0.854
1uz5A10.96591000.116Contact Map0.809
2ftsA10.97571000.127Contact Map0.823
1wu2A20.94651000.137Contact Map0.873
3rfqA30.41611000.666Contact Map0.694
1jljA30.41611000.675Contact Map0.746
4lhbA30.40631000.696Contact Map0.613
2pjkA30.38691000.698Contact Map0.69
1y5eA30.37231000.701Contact Map0.716
2pbqA30.39171000.716Contact Map0.581
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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