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OPENSEQ.org
BGLG - Cryptic beta-glucoside bgl operon antiterminator
UniProt: P11989 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10116
Length: 278 (275)
Sequences: 1322
Seq/Len: 4.81
BGLG
Paralog alert: 0.61 [within 20: 0.07] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
142_D 148_Q 3.537 1.00
86_R 136_E 3.337 1.00
16_V 24_K 3 1.00
9_L 15_V 2.717 1.00
252_G 258_K 2.563 1.00
234_K 241_W 2.526 1.00
187_I 205_L 2.395 1.00
79_I 137_A 2.392 1.00
188_K 194_N 2.338 1.00
230_Q 265_M 2.33 1.00
107_K 111_Q 2.173 1.00
244_A 268_A 2.088 1.00
182_E 254_Q 2.035 1.00
5_I 8_I 1.98 1.00
244_A 264_I 1.892 1.00
6_T 17_I 1.891 1.00
240_A 272_E 1.847 1.00
14_V 26_V 1.814 1.00
120_L 155_G 1.81 1.00
215_R 263_E 1.782 1.00
18_D 22_R 1.708 0.99
101_H 160_H 1.696 0.99
59_G 62_S 1.596 0.99
248_A 264_I 1.577 0.99
234_K 261_P 1.557 0.99
187_I 271_I 1.544 0.99
183_M 247_I 1.521 0.99
186_L 250_F 1.519 0.99
247_I 271_I 1.509 0.98
134_G 154_V 1.472 0.98
232_A 236_N 1.472 0.98
83_A 137_A 1.471 0.98
238_P 268_A 1.467 0.98
135_E 154_V 1.433 0.98
141_I 149_L 1.431 0.98
40_R 44_S 1.418 0.97
78_R 144_R 1.407 0.97
14_V 32_G 1.387 0.97
129_K 132_Q 1.384 0.97
82_L 136_E 1.378 0.97
84_Q 87_L 1.375 0.97
40_R 108_R 1.374 0.97
185_Q 189_F 1.349 0.96
98_L 160_H 1.314 0.95
190_Q 246_R 1.309 0.95
241_W 245_E 1.302 0.95
213_S 217_L 1.298 0.95
219_H 257_R 1.292 0.95
209_L 212_L 1.287 0.95
161_L 165_Q 1.271 0.94
191_F 195_Y 1.267 0.94
5_I 13_V 1.266 0.94
97_S 101_H 1.25 0.94
109_F 150_P 1.242 0.93
239_Q 244_A 1.241 0.93
72_V 76_C 1.24 0.93
245_E 261_P 1.229 0.93
138_L 142_D 1.221 0.93
210_K 214_W 1.212 0.92
42_N 45_G 1.205 0.92
134_G 137_A 1.194 0.91
213_S 255_Y 1.192 0.91
123_I 155_G 1.187 0.91
16_V 25_V 1.182 0.91
132_Q 135_E 1.179 0.91
139_T 148_Q 1.172 0.90
72_V 75_T 1.172 0.90
29_R 32_G 1.168 0.90
14_V 21_Q 1.164 0.90
25_V 29_R 1.161 0.90
208_H 270_N 1.158 0.90
222_I 266_F 1.153 0.89
233_V 268_A 1.151 0.89
189_F 212_L 1.147 0.89
224_D 265_M 1.143 0.89
48_K 101_H 1.138 0.89
94_I 164_A 1.127 0.88
195_Y 274_V 1.127 0.88
187_I 244_A 1.125 0.88
6_T 15_V 1.116 0.87
17_I 34_Q 1.114 0.87
242_Q 245_E 1.109 0.87
8_I 16_V 1.108 0.87
198_E 274_V 1.107 0.87
134_G 158_A 1.104 0.87
9_L 13_V 1.102 0.86
79_I 140_I 1.101 0.86
77_D 81_S 1.098 0.86
4_Q 40_R 1.085 0.85
188_K 255_Y 1.085 0.85
240_A 244_A 1.084 0.85
102_C 141_I 1.083 0.85
16_V 26_V 1.081 0.85
9_L 17_I 1.08 0.85
160_H 164_A 1.078 0.85
225_S 262_A 1.076 0.85
17_I 22_R 1.07 0.84
106_I 147_V 1.07 0.84
265_M 268_A 1.069 0.84
116_P 152_D 1.069 0.84
84_Q 90_L 1.067 0.84
245_E 264_I 1.061 0.83
7_K 27_M 1.061 0.83
121_W 189_F 1.06 0.83
24_K 228_S 1.06 0.83
173_V 177_T 1.052 0.83
79_I 141_I 1.052 0.83
4_Q 22_R 1.052 0.83
86_R 267_L 1.05 0.83
18_D 24_K 1.049 0.82
6_T 34_Q 1.048 0.82
17_I 20_Q 1.046 0.82
241_W 244_A 1.045 0.82
30_G 101_H 1.045 0.82
195_Y 271_I 1.043 0.82
176_V 213_S 1.039 0.82
224_D 228_S 1.038 0.82
233_V 265_M 1.037 0.81
83_A 161_L 1.037 0.81
201_S 205_L 1.035 0.81
142_D 149_L 1.027 0.81
240_A 271_I 1.024 0.80
191_F 243_C 1.016 0.80
32_G 104_F 1.011 0.79
240_A 275_R 1.008 0.79
196_Q 199_S 1.008 0.79
153_E 160_H 1.008 0.79
179_L 213_S 1.007 0.79
101_H 159_M 1.005 0.79
22_R 276_K 1.001 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1h99A10.79141000.373Contact Map0.598
3sqnA20.92091000.535Contact Map0.485
3rioA10.582799.90.557Contact Map0.695
3ufeA20.399399.70.685Contact Map0.767
1l1cA20.197898.90.801Contact Map0.593
1auuA20.197898.90.804Contact Map0.547
3nufA20.3885960.887Contact Map0.686
2prvA20.21227.60.958Contact Map0.31
3d5pA20.17997.10.958Contact Map0.322
1wtyA40.25186.60.959Contact Map0.319
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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