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OPENSEQ.org
NADA - Quinolinate synthase A
UniProt: P11458 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10630
Length: 347 (316)
Sequences: 1131
Seq/Len: 3.58
NADA
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
41_N 81_S 5.051 1.00
32_K 313_E 3.763 1.00
35_R 39_E 3.212 1.00
257_R 278_E 3.144 1.00
325_E 328_R 3.079 1.00
336_N 340_D 2.92 1.00
82_T 315_E 2.851 1.00
225_V 234_V 2.836 1.00
125_N 149_R 2.816 1.00
328_R 332_L 2.815 1.00
220_D 257_R 2.732 1.00
218_Y 257_R 2.619 1.00
239_A 245_Q 2.513 1.00
103_T 315_E 2.511 1.00
94_T 335_L 2.506 1.00
40_R 315_E 2.433 1.00
248_A 252_T 2.41 1.00
160_V 185_V 2.347 1.00
332_L 336_N 2.245 1.00
182_G 195_C 2.225 1.00
70_E 244_S 2.216 1.00
112_E 117_L 2.211 1.00
74_F 77_K 2.193 1.00
253_L 258_L 2.171 1.00
56_Q 268_Y 2.16 1.00
138_V 142_T 2.154 1.00
32_K 35_R 2.153 1.00
212_T 236_M 2.126 1.00
225_V 237_A 2.107 1.00
108_T 307_A 2.095 1.00
103_T 320_E 2.081 1.00
309_A 313_E 2.053 1.00
250_A 279_L 2.05 1.00
251_K 273_A 2.045 1.00
256_Q 276_D 2.01 1.00
323_V 328_R 1.991 1.00
40_R 103_T 1.947 1.00
325_E 329_E 1.909 1.00
115_L 118_G 1.895 1.00
34_K 37_L 1.867 1.00
246_L 270_M 1.839 0.99
215_Q 238_D 1.838 0.99
29_Y 309_A 1.777 0.99
82_T 103_T 1.771 0.99
138_V 150_A 1.771 0.99
96_K 320_E 1.759 0.99
70_E 74_F 1.757 0.99
60_E 70_E 1.74 0.99
215_Q 236_M 1.715 0.99
222_A 249_A 1.712 0.99
40_R 82_T 1.698 0.99
76_A 99_S 1.691 0.99
32_K 309_A 1.675 0.99
250_A 274_V 1.652 0.99
222_A 255_H 1.626 0.98
269_K 273_A 1.614 0.98
212_T 216_E 1.603 0.98
234_V 240_V 1.581 0.98
82_T 105_L 1.572 0.98
213_R 217_E 1.552 0.98
126_A 129_D 1.549 0.98
256_Q 278_E 1.532 0.97
84_L 105_L 1.531 0.97
251_K 274_V 1.53 0.97
43_V 80_A 1.519 0.97
160_V 164_D 1.518 0.97
165_H 341_F 1.511 0.97
266_I 270_M 1.486 0.97
179_K 197_Q 1.458 0.96
85_V 95_A 1.443 0.96
125_N 129_D 1.438 0.96
231_Q 235_D 1.437 0.96
92_G 106_M 1.435 0.96
185_V 193_I 1.433 0.96
114_S 299_W 1.425 0.96
152_W 165_H 1.42 0.95
172_K 192_D 1.413 0.95
157_S 246_L 1.406 0.95
330_R 333_V 1.402 0.95
208_T 236_M 1.396 0.95
222_A 253_L 1.381 0.94
221_A 259_I 1.373 0.94
96_K 322_H 1.356 0.94
202_V 299_W 1.356 0.94
89_R 112_E 1.345 0.93
258_L 277_K 1.33 0.93
257_R 280_L 1.321 0.93
72_A 99_S 1.301 0.92
71_M 85_V 1.294 0.92
337_R 340_D 1.293 0.91
310_E 314_Q 1.292 0.91
72_A 85_V 1.292 0.91
201_I 299_W 1.288 0.91
70_E 73_R 1.287 0.91
160_V 188_Q 1.277 0.91
131_H 194_L 1.255 0.90
126_A 130_A 1.245 0.89
211_L 223_I 1.245 0.89
86_A 308_I 1.23 0.89
30_R 34_K 1.226 0.88
46_A 58_A 1.224 0.88
84_L 308_I 1.224 0.88
52_P 56_Q 1.22 0.88
60_E 74_F 1.204 0.87
131_H 172_K 1.194 0.86
41_N 82_T 1.193 0.86
299_W 302_M 1.193 0.86
97_I 144_A 1.184 0.86
121_V 125_N 1.175 0.85
52_P 268_Y 1.17 0.85
142_T 224_L 1.169 0.85
179_K 204_D 1.16 0.84
114_S 202_V 1.145 0.83
311_A 319_H 1.143 0.83
218_Y 280_L 1.129 0.82
212_T 215_Q 1.11 0.81
54_I 308_I 1.107 0.80
31_E 35_R 1.105 0.80
250_A 270_M 1.104 0.80
138_V 176_A 1.096 0.79
206_F 295_A 1.093 0.79
329_E 332_L 1.09 0.79
73_R 339_L 1.088 0.79
224_L 250_A 1.088 0.79
45_V 75_G 1.074 0.77
140_A 153_V 1.071 0.77
289_A 292_R 1.062 0.76
146_V 176_A 1.06 0.76
220_D 256_Q 1.051 0.75
158_I 342_A 1.05 0.75
187_K 231_Q 1.047 0.75
41_N 80_A 1.046 0.75
163_I 185_V 1.046 0.75
114_S 199_A 1.045 0.75
248_A 251_K 1.037 0.74
164_D 190_G 1.035 0.74
41_N 79_P 1.028 0.73
310_E 313_E 1.028 0.73
106_M 321_V 1.02 0.72
224_L 246_L 1.019 0.72
241_G 246_L 1.018 0.72
162_L 342_A 1.011 0.71
150_A 334_P 1.009 0.71
159_A 181_L 1.002 0.70
115_L 299_W 1 0.70
50_T 54_I 1 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1wzuA10.85881000.196Contact Map0.682
2ekcA20.636978.70.971Contact Map0.444
2q5cA20.533154.80.975Contact Map0.274
1qopA10.665751.20.976Contact Map0.374
2pjuA40.587944.20.977Contact Map0.372
3n1uA10.478438.50.977Contact Map0.438
3navA20.677236.50.978Contact Map0.28
1rd5A20.662830.10.979Contact Map0.221
1ujpA10.642728.20.979Contact Map0.451
1tqxA20.579327.60.979Contact Map0.395
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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