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OPENSEQ.org

ENTF - Enterobactin synthase component F
UniProt: P11454 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10264
Length: 1293 (1138)
Sequences: 4794
Seq/Len: 4.21

ENTF
Paralog alert: 0.51 [within 20: 0.39] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
597_T 614_M 4.13 1.00
535_L 544_L 3.787 1.00
879_L 925_Q 3.781 1.00
507_S 533_L 3.767 1.00
802_L 842_A 3.554 1.00
505_G 811_Q 3.538 1.00
505_G 596_H 3.148 1.00
980_I 1016_L 3.035 1.00
268_D 297_G 2.977 1.00
786_I 850_V 2.954 1.00
786_I 842_A 2.842 1.00
550_D 602_F 2.84 1.00
462_A 487_R 2.725 1.00
61_R 74_D 2.668 1.00
983_A 1012_L 2.642 1.00
616_G 811_Q 2.61 1.00
799_A 853_L 2.578 1.00
51_G 156_I 2.568 1.00
493_L 524_A 2.544 1.00
805_T 835_M 2.525 1.00
1025_T 1028_Q 2.501 1.00
304_E 312_R 2.483 1.00
787_L 803_Y 2.465 1.00
502_V 530_A 2.462 1.00
306_L 420_F 2.449 1.00
491_V 527_E 2.432 1.00
213_A 402_D 2.421 1.00
34_E 129_R 2.38 1.00
259_W 416_L 2.376 1.00
998_D 1001_A 2.366 1.00
509_A 553_P 2.364 1.00
263_L 412_R 2.346 1.00
484_R 488_E 2.323 1.00
862_I 895_A 2.313 1.00
843_R 851_E 2.284 1.00
784_L 804_L 2.278 1.00
487_R 527_E 2.252 1.00
243_L 251_L 2.242 1.00
756_S 784_L 2.239 1.00
464_Q 468_T 2.199 1.00
347_P 350_N 2.18 1.00
638_V 663_K 2.169 1.00
496_L 500_R 2.165 1.00
493_L 520_L 2.163 1.00
619_A 752_A 2.161 1.00
344_L 347_P 2.145 1.00
491_V 495_N 2.144 1.00
996_D 1036_A 2.131 1.00
907_G 939_L 2.121 1.00
600_I 814_L 2.11 1.00
970_R 996_D 2.099 1.00
783_G 827_D 2.098 1.00
886_V 953_L 2.09 1.00
741_P 759_P 2.08 1.00
973_K 995_A 2.074 1.00
464_Q 467_K 2.068 1.00
239_L 248_R 2.064 1.00
986_S 1015_Q 2.049 1.00
994_D 997_A 2.042 1.00
860_L 869_L 2.022 1.00
616_G 619_A 2.018 1.00
331_I 335_S 2.01 1.00
816_R 819_L 1.996 1.00
827_D 833_E 1.99 1.00
695_S 724_E 1.989 1.00
49_V 53_A 1.986 1.00
468_T 471_A 1.977 1.00
506_D 530_A 1.973 1.00
622_N 781_N 1.967 1.00
504_P 596_H 1.957 1.00
976_S 1043_D 1.942 1.00
783_G 805_T 1.934 1.00
518_L 645_C 1.934 1.00
403_E 407_I 1.929 1.00
637_D 688_T 1.925 1.00
343_P 346_G 1.913 1.00
502_V 506_D 1.909 1.00
680_Q 684_E 1.909 1.00
995_A 1035_V 1.907 1.00
597_T 811_Q 1.906 1.00
691_H 754_D 1.881 1.00
346_G 350_N 1.88 1.00
270_A 295_P 1.876 1.00
649_V 691_H 1.863 1.00
200_Q 316_Q 1.858 1.00
51_G 153_I 1.848 1.00
638_V 687_V 1.848 1.00
548_L 553_P 1.843 1.00
637_D 662_A 1.842 1.00
1034_T 1037_K 1.835 1.00
394_I 406_L 1.834 1.00
136_Y 141_V 1.825 1.00
54_Q 152_Q 1.822 1.00
257_A 298_I 1.82 1.00
998_D 1033_S 1.815 1.00
507_S 600_I 1.805 1.00
637_D 717_K 1.805 1.00
910_V 945_L 1.802 1.00
117_L 140_L 1.797 1.00
619_A 809_L 1.791 1.00
908_Y 959_P 1.788 1.00
7_L 69_V 1.78 1.00
487_R 491_V 1.769 0.99
36_T 129_R 1.766 0.99
521_A 525_I 1.763 0.99
412_R 438_E 1.762 0.99
510_V 522_L 1.756 0.99
487_R 490_V 1.755 0.99
347_P 351_I 1.749 0.99
416_L 431_V 1.749 0.99
61_R 114_G 1.747 0.99
974_A 995_A 1.747 0.99
512_L 521_A 1.746 0.99
1007_L 1010_M 1.745 0.99
745_L 754_D 1.743 0.99
975_G 978_T 1.742 0.99
984_F 1035_V 1.742 0.99
470_D 484_R 1.739 0.99
942_L 945_L 1.733 0.99
643_T 649_V 1.732 0.99
193_D 323_H 1.732 0.99
668_E 671_A 1.726 0.99
461_V 465_A 1.714 0.99
1017_S 1023_Q 1.707 0.99
509_A 548_L 1.704 0.99
347_P 352_K 1.701 0.99
909_L 939_L 1.7 0.99
1007_L 1026_P 1.697 0.99
506_D 554_S 1.685 0.99
623_R 652_W 1.685 0.99
691_H 745_L 1.681 0.99
595_H 618_T 1.677 0.99
419_Q 432_D 1.672 0.99
875_V 926_L 1.665 0.99
652_W 754_D 1.662 0.99
489_Q 517_F 1.658 0.99
344_L 350_N 1.654 0.99
897_A 900_G 1.653 0.99
472_P 480_L 1.644 0.99
906_V 940_L 1.642 0.99
674_D 677_A 1.641 0.99
510_V 521_A 1.639 0.99
999_F 1004_G 1.638 0.99
462_A 527_E 1.633 0.99
343_P 347_P 1.631 0.99
229_L 392_I 1.631 0.99
1005_H 1008_L 1.628 0.99
640_A 682_F 1.622 0.99
653_E 691_H 1.62 0.99
345_F 350_N 1.614 0.99
502_V 508_V 1.611 0.99
649_V 722_S 1.606 0.99
446_N 449_Q 1.603 0.99
546_M 609_R 1.597 0.99
784_L 802_L 1.589 0.99
177_V 180_E 1.587 0.99
45_A 49_V 1.587 0.99
462_A 490_V 1.586 0.99
350_N 353_V 1.584 0.99
378_L 384_P 1.584 0.99
48_V 120_H 1.582 0.99
382_L 392_I 1.582 0.99
671_A 677_A 1.581 0.99
503_K 506_D 1.581 0.99
575_L 578_N 1.58 0.99
642_K 693_V 1.577 0.99
983_A 1016_L 1.575 0.99
652_W 691_H 1.572 0.99
825_I 835_M 1.571 0.99
546_M 602_F 1.57 0.98
472_P 482_S 1.569 0.98
487_R 587_A 1.569 0.98
225_L 398_K 1.556 0.98
39_V 130_W 1.553 0.98
481_F 520_L 1.55 0.98
691_H 694_P 1.549 0.98
1012_L 1029_V 1.547 0.98
623_R 754_D 1.547 0.98
307_P 425_A 1.544 0.98
1005_H 1016_L 1.544 0.98
539_Y 547_M 1.542 0.98
667_A 681_F 1.54 0.98
980_I 1035_V 1.536 0.98
691_H 696_M 1.534 0.98
791_M 803_Y 1.533 0.98
457_L 620_I 1.532 0.98
299_H 304_E 1.53 0.98
1005_H 1009_A 1.526 0.98
346_G 352_K 1.511 0.98
193_D 325_R 1.503 0.98
665_V 681_F 1.5 0.98
255_L 417_I 1.5 0.98
897_A 903_R 1.5 0.98
981_A 1035_V 1.499 0.98
886_V 945_L 1.498 0.98
640_A 667_A 1.497 0.98
328_A 332_V 1.487 0.98
305_T 308_E 1.485 0.98
44_L 153_I 1.477 0.98
539_Y 949_A 1.476 0.98
665_V 687_V 1.476 0.98
974_A 1043_D 1.471 0.97
845_L 849_A 1.466 0.97
613_V 810_A 1.466 0.97
877_Q 884_Q 1.465 0.97
194_A 334_D 1.465 0.97
519_T 654_F 1.464 0.97
908_Y 961_P 1.463 0.97
250_D 314_A 1.461 0.97
980_I 1039_A 1.459 0.97
970_R 995_A 1.459 0.97
539_Y 646_S 1.459 0.97
212_P 215_L 1.453 0.97
50_A 53_A 1.448 0.97
845_L 851_E 1.448 0.97
623_R 691_H 1.447 0.97
549_E 609_R 1.442 0.97
394_I 410_A 1.441 0.97
295_P 331_I 1.44 0.97
979_I 1019_Q 1.436 0.97
463_E 467_K 1.435 0.97
1005_H 1010_M 1.434 0.97
62_F 140_L 1.429 0.97
257_A 271_A 1.429 0.97
263_L 409_H 1.427 0.97
987_L 1012_L 1.422 0.97
657_P 664_L 1.421 0.97
88_R 124_Q 1.421 0.97
643_T 691_H 1.418 0.97
50_A 160_W 1.418 0.97
643_T 745_L 1.415 0.97
1016_L 1022_R 1.414 0.97
524_A 528_A 1.41 0.96
194_A 326_Y 1.41 0.96
1121_A 1124_L 1.409 0.96
799_A 841_V 1.408 0.96
785_R 829_F 1.406 0.96
969_G 992_V 1.404 0.96
235_E 418_A 1.4 0.96
873_D 893_N 1.398 0.96
974_A 978_T 1.398 0.96
1005_H 1026_P 1.398 0.96
652_W 745_L 1.396 0.96
862_I 867_I 1.394 0.96
1027_G 1031_V 1.392 0.96
301_A 304_E 1.391 0.96
623_R 752_A 1.39 0.96
44_L 132_W 1.389 0.96
346_G 351_I 1.385 0.96
423_D 426_L 1.385 0.96
1011_K 1015_Q 1.383 0.96
174_F 177_V 1.38 0.96
427_L 430_D 1.376 0.96
476_D 516_V 1.375 0.96
43_L 160_W 1.373 0.96
751_A 809_L 1.372 0.96
649_V 652_W 1.372 0.96
637_D 689_T 1.367 0.96
669_P 672_H 1.366 0.96
475_A 685_Y 1.363 0.95
156_I 160_W 1.362 0.95
722_S 752_A 1.358 0.95
784_L 842_A 1.357 0.95
481_F 516_V 1.35 0.95
242_Q 421_A 1.349 0.95
114_G 117_L 1.349 0.95
681_F 685_Y 1.347 0.95
41_S 122_L 1.346 0.95
786_I 802_L 1.345 0.95
227_L 407_I 1.344 0.95
633_L 662_A 1.344 0.95
345_F 352_K 1.341 0.95
758_Y 774_P 1.336 0.95
443_A 446_N 1.336 0.95
691_H 722_S 1.336 0.95
460_L 621_V 1.336 0.95
1013_A 1029_V 1.335 0.95
19_K 64_E 1.335 0.95
595_H 616_G 1.334 0.95
345_F 351_I 1.333 0.95
490_V 527_E 1.332 0.95
623_R 653_E 1.331 0.95
623_R 722_S 1.33 0.95
268_D 299_H 1.326 0.95
60_M 73_V 1.322 0.94
495_N 588_P 1.321 0.94
909_L 941_Q 1.32 0.94
475_A 663_K 1.317 0.94
1076_G 1081_F 1.316 0.94
256_A 347_P 1.315 0.94
1028_Q 1041_I 1.315 0.94
722_S 745_L 1.313 0.94
502_V 528_A 1.312 0.94
474_L 516_V 1.311 0.94
88_R 127_D 1.31 0.94
261_G 264_C 1.309 0.94
212_P 405_T 1.308 0.94
629_N 780_W 1.308 0.94
149_I 287_T 1.307 0.94
1009_A 1013_A 1.307 0.94
408_Q 412_R 1.306 0.94
642_K 754_D 1.303 0.94
14_I 289_P 1.303 0.94
550_D 816_R 1.301 0.94
615_V 752_A 1.301 0.94
151_R 285_T 1.3 0.94
255_L 420_F 1.3 0.94
1007_L 1016_L 1.299 0.94
344_L 351_I 1.299 0.94
60_M 71_Q 1.299 0.94
649_V 754_D 1.297 0.94
722_S 754_D 1.291 0.93
620_I 753_V 1.291 0.93
248_R 390_L 1.283 0.93
982_A 1019_Q 1.281 0.93
10_A 13_G 1.279 0.93
878_A 929_T 1.276 0.93
300_I 304_E 1.276 0.93
973_K 1036_A 1.274 0.93
326_Y 334_D 1.274 0.93
56_D 173_P 1.271 0.93
500_R 555_L 1.27 0.93
574_S 578_N 1.268 0.93
521_A 557_I 1.267 0.93
462_A 491_V 1.266 0.93
55_A 152_Q 1.265 0.93
627_M 745_L 1.265 0.93
505_G 530_A 1.263 0.92
652_W 696_M 1.263 0.92
479_Y 489_Q 1.262 0.92
432_D 439_Y 1.26 0.92
653_E 745_L 1.259 0.92
642_K 696_M 1.259 0.92
343_P 351_I 1.258 0.92
642_K 692_F 1.257 0.92
858_D 955_R 1.257 0.92
627_M 652_W 1.256 0.92
258_L 309_L 1.255 0.92
256_A 380_L 1.252 0.92
720_F 745_L 1.247 0.92
195_A 199_E 1.245 0.92
758_Y 849_A 1.243 0.92
315_A 319_K 1.24 0.92
343_P 350_N 1.238 0.91
1000_F 1030_M 1.235 0.91
474_L 519_T 1.233 0.91
472_P 663_K 1.23 0.91
865_Q 933_H 1.228 0.91
641_Q 664_L 1.227 0.91
979_I 982_A 1.226 0.91
159_T 163_G 1.225 0.91
1032_A 1041_I 1.224 0.91
377_D 384_P 1.221 0.91
512_L 557_I 1.22 0.91
344_L 352_K 1.215 0.90
1009_A 1026_P 1.214 0.90
505_G 597_T 1.213 0.90
110_R 113_S 1.213 0.90
516_V 520_L 1.21 0.90
533_L 551_A 1.209 0.90
623_R 627_M 1.208 0.90
458_S 617_Q 1.203 0.90
692_F 697_L 1.199 0.90
345_F 348_V 1.199 0.90
981_A 995_A 1.198 0.90
1028_Q 1031_V 1.197 0.90
694_P 697_L 1.195 0.89
638_V 665_V 1.194 0.89
651_V 753_V 1.194 0.89
173_P 176_D 1.192 0.89
531_A 597_T 1.19 0.89
472_P 475_A 1.188 0.89
196_F 319_K 1.185 0.89
261_G 300_I 1.184 0.89
178_V 181_Y 1.184 0.89
176_D 180_E 1.182 0.89
624_L 659_I 1.179 0.89
642_K 652_W 1.179 0.89
649_V 692_F 1.178 0.89
225_L 403_E 1.177 0.88
862_I 903_R 1.177 0.88
725_A 852_Y 1.176 0.88
727_P 730_L 1.175 0.88
643_T 653_E 1.174 0.88
977_E 995_A 1.174 0.88
1079_W 1083_V 1.173 0.88
507_S 531_A 1.173 0.88
893_N 907_G 1.173 0.88
877_Q 885_A 1.172 0.88
693_V 754_D 1.172 0.88
751_A 804_L 1.171 0.88
38_E 128_N 1.169 0.88
194_A 198_A 1.169 0.88
981_A 993_Q 1.168 0.88
634_T 637_D 1.167 0.88
973_K 977_E 1.164 0.88
923_Q 939_L 1.162 0.88
796_P 844_W 1.162 0.88
627_M 691_H 1.158 0.87
221_S 397_N 1.155 0.87
1022_R 1042_I 1.155 0.87
691_H 697_L 1.155 0.87
551_A 602_F 1.154 0.87
546_M 550_D 1.153 0.87
693_V 745_L 1.152 0.87
1016_L 1020_V 1.151 0.87
652_W 722_S 1.15 0.87
1035_V 1038_L 1.15 0.87
13_G 17_A 1.149 0.87
980_I 983_A 1.148 0.87
445_L 448_T 1.144 0.87
258_L 416_L 1.144 0.87
788_D 792_H 1.144 0.87
347_P 353_V 1.141 0.86
691_H 751_A 1.141 0.86
111_V 139_L 1.141 0.86
642_K 734_W 1.138 0.86
476_D 479_Y 1.138 0.86
623_R 753_V 1.137 0.86
1010_M 1026_P 1.137 0.86
726_L 744_N 1.137 0.86
204_L 270_A 1.135 0.86
841_V 856_S 1.135 0.86
641_Q 649_V 1.132 0.86
468_T 484_R 1.132 0.86
100_L 123_I 1.132 0.86
1124_L 1127_Q 1.13 0.86
196_F 320_M 1.13 0.86
626_W 745_L 1.129 0.86
1016_L 1025_T 1.127 0.85
253_L 257_A 1.127 0.85
181_Y 185_R 1.126 0.85
1121_A 1125_E 1.126 0.85
976_S 1020_V 1.124 0.85
378_L 382_L 1.123 0.85
649_V 745_L 1.121 0.85
620_I 651_V 1.12 0.85
985_S 992_V 1.116 0.85
255_L 416_L 1.114 0.85
785_R 827_D 1.111 0.84
592_S 596_H 1.11 0.84
345_F 353_V 1.11 0.84
980_I 1012_L 1.108 0.84
547_M 646_S 1.107 0.84
104_D 135_R 1.107 0.84
227_L 403_E 1.106 0.84
461_V 523_H 1.104 0.84
443_A 447_A 1.103 0.84
649_V 653_E 1.103 0.84
650_S 653_E 1.103 0.84
623_R 696_M 1.102 0.84
751_A 754_D 1.102 0.84
1061_R 1064_N 1.098 0.83
531_A 600_I 1.097 0.83
895_A 903_R 1.097 0.83
250_D 318_K 1.097 0.83
693_V 722_S 1.096 0.83
976_S 979_I 1.096 0.83
667_A 678_M 1.094 0.83
990_C 993_Q 1.092 0.83
697_L 754_D 1.092 0.83
897_A 901_D 1.091 0.83
801_D 837_R 1.09 0.83
545_K 549_E 1.09 0.83
803_Y 825_I 1.089 0.83
623_R 649_V 1.089 0.83
803_Y 823_R 1.089 0.83
520_L 524_A 1.087 0.82
734_W 742_L 1.087 0.82
641_Q 666_M 1.086 0.82
692_F 696_M 1.085 0.82
827_D 835_M 1.085 0.82
718_Q 743_H 1.084 0.82
1012_L 1016_L 1.084 0.82
648_D 748_P 1.083 0.82
869_L 893_N 1.083 0.82
875_V 929_T 1.083 0.82
668_E 677_A 1.079 0.82
414_K 418_A 1.077 0.82
995_A 1036_A 1.077 0.82
348_V 351_I 1.077 0.82
240_A 384_P 1.075 0.82
39_V 122_L 1.075 0.82
1120_L 1124_L 1.073 0.81
246_V 250_D 1.072 0.81
593_Q 596_H 1.07 0.81
721_C 726_L 1.07 0.81
918_D 921_A 1.069 0.81
1079_W 1082_S 1.068 0.81
830_A 833_E 1.067 0.81
803_Y 837_R 1.067 0.81
652_W 656_W 1.065 0.81
799_A 856_S 1.065 0.81
692_F 754_D 1.063 0.81
726_L 742_L 1.061 0.80
623_R 745_L 1.061 0.80
446_N 844_W 1.061 0.80
628_Q 660_A 1.061 0.80
229_L 410_A 1.06 0.80
693_V 696_M 1.059 0.80
628_Q 656_W 1.058 0.80
858_D 873_D 1.055 0.80
656_W 691_H 1.055 0.80
627_M 643_T 1.054 0.80
643_T 692_F 1.052 0.80
1016_L 1042_I 1.051 0.79
254_A 309_L 1.051 0.79
1115_V 1119_H 1.051 0.79
633_L 637_D 1.049 0.79
640_A 681_F 1.048 0.79
380_L 394_I 1.048 0.79
12_P 68_E 1.047 0.79
18_E 23_L 1.046 0.79
345_F 349_L 1.045 0.79
203_Q 297_G 1.043 0.79
626_W 693_V 1.042 0.79
693_V 697_L 1.041 0.79
254_A 313_L 1.04 0.78
452_I 781_N 1.04 0.78
1010_M 1014_A 1.039 0.78
502_V 555_L 1.038 0.78
541_D 545_K 1.037 0.78
223_D 399_Q 1.037 0.78
8_V 11_Q 1.037 0.78
449_Q 781_N 1.037 0.78
40_D 43_L 1.036 0.78
238_Q 418_A 1.036 0.78
221_S 399_Q 1.035 0.78
1032_A 1037_K 1.034 0.78
624_L 656_W 1.034 0.78
196_F 200_Q 1.033 0.78
420_F 431_V 1.032 0.78
642_K 720_F 1.032 0.78
623_R 755_V 1.032 0.78
198_A 334_D 1.032 0.78
662_A 688_T 1.03 0.78
721_C 745_L 1.03 0.78
456_T 459_A 1.029 0.77
259_W 263_L 1.029 0.77
652_W 753_V 1.029 0.77
978_T 982_A 1.028 0.77
401_Y 406_L 1.028 0.77
656_W 754_D 1.027 0.77
396_A 401_Y 1.027 0.77
694_P 754_D 1.026 0.77
976_S 1042_I 1.024 0.77
875_V 878_A 1.023 0.77
1063_G 1067_T 1.023 0.77
1123_L 1127_Q 1.022 0.77
330_Q 333_R 1.021 0.77
96_T 99_A 1.021 0.77
694_P 730_L 1.021 0.77
402_D 405_T 1.019 0.76
787_L 835_M 1.018 0.76
696_M 754_D 1.018 0.76
200_Q 319_K 1.016 0.76
444_Q 447_A 1.015 0.76
779_V 782_T 1.015 0.76
641_Q 754_D 1.015 0.76
191_Q 195_A 1.014 0.76
56_D 59_R 1.013 0.76
689_T 718_Q 1.012 0.76
691_H 753_V 1.011 0.76
122_L 132_W 1.01 0.76
314_A 318_K 1.01 0.76
1016_L 1026_P 1.009 0.75
407_I 411_E 1.009 0.75
259_W 413_L 1.009 0.75
235_E 421_A 1.009 0.75
653_E 696_M 1.008 0.75
50_A 156_I 1.008 0.75
985_S 993_Q 1.006 0.75
728_A 732_R 1.005 0.75
46_R 160_W 1.004 0.75
653_E 754_D 1.004 0.75
619_A 622_N 1.003 0.75
748_P 754_D 1.002 0.75
896_A 900_G 1.002 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vsqA10.95671000.264Contact Map0.643
4dg8A10.47411000.572Contact Map0.611
4iz6A20.47251000.601Contact Map0.544
1amuA20.42921000.638Contact Map0.741
4gr5A40.43231000.652Contact Map0.638
3vnrA10.41451000.669Contact Map0.693
3g7sA20.39981000.673Contact Map0.625
3tsyA10.63031000.676Contact Map0.576
3l8cA20.39131000.682Contact Map0.678
3ni2A10.3961000.683Contact Map0.602

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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