May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
LPXB - Lipid-A-disaccharide synthase
UniProt: P10441 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10546
Length: 382 (377)
Sequences: 1075
Seq/Len: 2.85
LPXB
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_G 97_I 5.123 1.00
291_V 313_S 4.104 1.00
142_L 162_R 3.419 1.00
312_V 328_L 3.405 1.00
321_R 357_T 3.367 1.00
194_L 228_I 3.081 1.00
8_T 37_R 2.781 1.00
122_S 154_Y 2.627 1.00
208_L 274_A 2.57 1.00
145_A 161_C 2.445 1.00
333_E 336_K 2.351 1.00
351_S 355_H 2.342 1.00
273_L 278_A 2.286 1.00
26_I 51_C 2.265 1.00
118_I 144_L 2.264 1.00
32_H 375_Q 2.254 1.00
257_L 264_A 2.218 1.00
143_V 154_Y 2.213 1.00
72_L 76_L 2.12 1.00
94_F 110_L 2.111 1.00
93_V 118_I 2.09 1.00
196_L 216_A 2.065 1.00
218_L 338_A 2.063 1.00
331_E 336_K 2.024 1.00
124_S 166_H 2.007 1.00
232_L 241_F 1.996 1.00
59_E 74_R 1.989 1.00
238_R 242_E 1.968 0.99
131_K 134_F 1.955 0.99
219_L 226_L 1.916 0.99
297_P 301_W 1.878 0.99
27_R 49_E 1.868 0.99
26_I 38_F 1.858 0.99
223_Y 342_L 1.83 0.99
67_E 299_T 1.822 0.99
194_L 226_L 1.811 0.99
272_L 292_G 1.809 0.99
319_A 323_L 1.806 0.99
151_K 155_D 1.799 0.99
100_P 128_W 1.784 0.99
40_G 51_C 1.781 0.99
270_A 341_L 1.753 0.99
310_D 320_G 1.723 0.98
101_D 129_R 1.71 0.98
125_V 133_V 1.706 0.98
195_A 268_S 1.701 0.98
10_A 85_R 1.689 0.98
10_A 86_F 1.68 0.98
215_T 337_L 1.662 0.98
177_D 180_A 1.623 0.97
301_W 305_R 1.59 0.97
68_V 101_D 1.581 0.97
219_L 342_L 1.58 0.97
286_K 362_H 1.572 0.97
42_A 51_C 1.57 0.97
8_T 39_V 1.567 0.97
218_L 335_Q 1.535 0.96
273_L 282_C 1.532 0.96
121_V 146_F 1.513 0.95
222_T 342_L 1.503 0.95
130_Q 308_K 1.498 0.95
211_D 294_R 1.489 0.95
188_P 191_A 1.469 0.94
25_L 95_V 1.464 0.94
28_A 371_E 1.452 0.94
9_I 93_V 1.412 0.93
96_G 117_T 1.41 0.93
271_A 282_C 1.406 0.93
152_A 156_K 1.399 0.92
265_M 282_C 1.385 0.92
238_R 258_D 1.385 0.92
83_T 109_N 1.381 0.92
195_A 265_M 1.381 0.92
271_A 287_C 1.379 0.92
153_F 317_L 1.378 0.92
96_G 119_H 1.374 0.91
152_A 155_D 1.37 0.91
232_L 256_L 1.369 0.91
327_L 340_A 1.367 0.91
191_A 227_E 1.367 0.91
325_K 340_A 1.358 0.91
73_R 76_L 1.342 0.90
25_L 373_A 1.342 0.90
195_A 271_A 1.337 0.90
170_D 369_A 1.336 0.90
22_G 46_M 1.334 0.90
319_A 361_L 1.33 0.90
300_F 304_K 1.324 0.89
261_G 273_L 1.318 0.89
79_R 105_T 1.314 0.89
272_L 341_L 1.312 0.89
212_F 292_G 1.311 0.89
146_F 163_F 1.306 0.88
76_L 80_A 1.298 0.88
30_K 49_E 1.295 0.88
143_V 161_C 1.285 0.87
311_Y 322_E 1.281 0.87
375_Q 379_E 1.277 0.87
223_Y 346_A 1.268 0.86
260_M 263_E 1.266 0.86
119_H 124_S 1.264 0.86
265_M 271_A 1.263 0.86
181_A 185_L 1.259 0.86
227_E 255_H 1.258 0.86
57_M 61_A 1.242 0.85
31_E 371_E 1.241 0.85
8_T 89_L 1.234 0.84
80_A 84_K 1.221 0.83
85_R 89_L 1.219 0.83
286_K 359_R 1.216 0.83
274_A 278_A 1.215 0.83
124_S 147_L 1.215 0.83
87_G 113_Q 1.213 0.83
130_Q 157_Y 1.212 0.83
368_N 371_E 1.206 0.82
239_E 242_E 1.205 0.82
14_G 18_G 1.2 0.82
211_D 332_C 1.189 0.81
231_P 264_A 1.186 0.81
340_A 343_P 1.182 0.81
321_R 360_E 1.177 0.80
118_I 377_V 1.177 0.80
24_G 370_D 1.167 0.80
303_A 307_V 1.164 0.79
26_I 46_M 1.161 0.79
343_P 350_T 1.16 0.79
292_G 332_C 1.157 0.79
197_L 278_A 1.155 0.79
96_G 107_E 1.154 0.78
170_D 372_Q 1.147 0.78
188_P 227_E 1.13 0.76
145_A 151_K 1.129 0.76
12_V 106_L 1.126 0.76
279_A 313_S 1.124 0.76
214_K 334_P 1.123 0.76
23_A 45_R 1.121 0.76
206_E 240_Q 1.116 0.75
24_G 170_D 1.116 0.75
328_L 332_C 1.114 0.75
122_S 143_V 1.112 0.75
19_D 43_G 1.109 0.74
183_D 189_H 1.109 0.74
63_M 124_S 1.106 0.74
289_M 324_V 1.103 0.74
336_K 339_A 1.101 0.74
335_Q 339_A 1.1 0.74
348_G 351_S 1.099 0.74
39_V 89_L 1.098 0.73
25_L 120_Y 1.098 0.73
239_E 243_R 1.096 0.73
357_T 360_E 1.095 0.73
342_L 346_A 1.095 0.73
37_R 52_E 1.092 0.73
84_K 88_E 1.085 0.72
211_D 214_K 1.082 0.72
140_T 143_V 1.078 0.71
21_L 121_V 1.077 0.71
147_L 317_L 1.075 0.71
133_V 137_G 1.071 0.71
39_V 85_R 1.071 0.71
133_V 153_F 1.069 0.71
38_F 95_V 1.068 0.70
208_L 332_C 1.068 0.70
196_L 292_G 1.061 0.70
144_L 376_A 1.058 0.69
42_A 53_A 1.048 0.68
118_I 380_L 1.047 0.68
292_G 337_L 1.043 0.68
32_H 371_E 1.042 0.68
151_K 161_C 1.036 0.67
298_F 302_L 1.032 0.67
71_R 74_R 1.031 0.67
86_F 110_L 1.026 0.66
278_A 282_C 1.024 0.66
55_Y 78_I 1.022 0.66
334_P 338_A 1.02 0.65
230_V 254_V 1.02 0.65
215_T 338_A 1.017 0.65
9_I 36_A 1.015 0.65
11_L 51_C 1.014 0.65
355_H 359_R 1.014 0.65
33_V 378_L 1.012 0.64
29_L 36_A 1.005 0.64
208_L 211_D 1.003 0.63
344_L 348_G 1.002 0.63
54_W 85_R 1.002 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v4vA20.89791000.728Contact Map0.668
1vgvA40.90051000.731Contact Map0.707
3dzcA20.90841000.742Contact Map0.713
4fkzA20.90841000.77Contact Map0.717
2gt1A20.80891000.787Contact Map0.549
2iyaA20.89531000.797Contact Map0.57
4hwgA10.903199.90.804Contact Map0.6
3ot5A40.908499.90.805Contact Map0.71
1pswA10.853499.90.807Contact Map0.55
3otgA10.903199.90.808Contact Map0.543
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0952 seconds.