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OPENSEQ.org
SECA - Protein translocase subunit SecA
UniProt: P10408 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10936
Length: 901 (899)
Sequences: 1736
Seq/Len: 1.93
SECA
Paralog alert: 0.14 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
46_K 49_E 5.185 1.00
53_R 58_E 5.08 1.00
28_I 88_L 4.787 1.00
443_K 472_A 4.645 1.00
116_A 128_V 4.467 1.00
36_E 76_K 4.324 1.00
177_G 182_Y 4.172 1.00
442_I 454_V 4.134 1.00
555_H 583_S 4.061 1.00
52_A 56_K 3.878 1.00
262_H 281_L 3.806 1.00
38_L 46_K 3.664 1.00
204_H 385_E 3.628 1.00
122_T 204_H 3.445 1.00
29_N 85_D 3.431 1.00
433_E 615_G 3.415 1.00
474_I 500_V 3.312 1.00
349_W 357_V 3.151 1.00
477_N 486_N 3.041 1.00
198_R 664_N 2.974 1.00
443_K 447_A 2.947 1.00
35_M 70_V 2.945 1.00
39_S 42_E 2.908 1.00
180_N 377_F 2.787 1.00
497_P 547_A 2.781 1.00
54_L 59_V 2.671 1.00
331_G 364_Q 2.67 1.00
466_S 476_H 2.659 1.00
83_H 114_L 2.622 1.00
751_E 760_R 2.612 1.00
431_E 461_K 2.589 1.00
741_A 745_E 2.567 1.00
33_P 36_E 2.56 1.00
53_R 66_E 2.525 1.00
54_L 63_L 2.521 1.00
59_V 62_N 2.491 1.00
54_L 121_L 2.43 1.00
41_E 44_K 2.411 1.00
395_D 398_A 2.403 1.00
546_D 550_E 2.355 1.00
50_F 70_V 2.346 1.00
483_F 486_N 2.332 1.00
441_D 444_E 2.325 1.00
547_A 550_E 2.324 1.00
46_K 50_F 2.324 1.00
334_I 343_T 2.295 1.00
43_L 70_V 2.291 1.00
91_G 115_P 2.287 1.00
445_R 448_K 2.269 1.00
24_V 92_M 2.26 1.00
263_F 318_A 2.25 1.00
244_P 317_H 2.238 1.00
47_T 117_Y 2.218 1.00
441_D 587_Y 2.195 1.00
50_F 117_Y 2.16 0.99
157_N 166_K 2.149 0.99
116_A 147_F 2.149 0.99
446_T 498_A 2.148 0.99
423_L 583_S 2.141 0.99
887_C 896_C 2.127 0.99
685_K 736_R 2.126 0.99
32_E 82_R 2.123 0.99
48_A 52_A 2.117 0.99
440_E 472_A 2.116 0.99
885_C 889_S 2.111 0.99
748_Q 752_E 2.103 0.99
99_I 401_F 2.098 0.99
446_T 475_K 2.098 0.99
195_P 668_D 2.082 0.99
497_P 551_A 2.082 0.99
885_C 896_C 2.074 0.99
144_R 148_E 2.068 0.99
81_M 84_F 2.049 0.99
44_K 48_A 2.024 0.99
327_I 343_T 1.998 0.99
194_S 197_E 1.983 0.99
887_C 890_G 1.976 0.99
143_N 147_F 1.972 0.99
54_L 62_N 1.969 0.99
46_K 70_V 1.958 0.99
81_M 146_L 1.958 0.99
889_S 896_C 1.955 0.99
702_D 705_G 1.947 0.99
45_G 48_A 1.927 0.98
885_C 890_G 1.891 0.98
335_I 349_W 1.89 0.98
21_M 89_L 1.886 0.98
21_M 96_E 1.856 0.98
516_G 547_A 1.843 0.98
21_M 92_M 1.828 0.98
441_D 445_R 1.819 0.98
760_R 763_E 1.818 0.98
78_V 146_L 1.817 0.98
129_V 182_Y 1.808 0.97
116_A 126_V 1.806 0.97
681_E 744_I 1.798 0.97
890_G 896_C 1.791 0.97
20_R 96_E 1.791 0.97
737_E 741_A 1.785 0.97
148_E 154_V 1.784 0.97
119_N 386_K 1.779 0.97
747_Y 763_E 1.778 0.97
689_D 736_R 1.777 0.97
445_R 450_Q 1.774 0.97
887_C 897_H 1.765 0.97
83_H 113_T 1.765 0.97
127_H 384_Y 1.757 0.97
493_Q 496_Y 1.756 0.97
140_A 156_I 1.755 0.97
70_V 117_Y 1.754 0.97
54_L 122_T 1.753 0.97
887_C 898_G 1.752 0.97
887_C 893_Y 1.744 0.97
165_A 168_E 1.74 0.97
893_Y 896_C 1.729 0.96
885_C 897_H 1.724 0.96
432_A 436_Q 1.716 0.96
543_V 547_A 1.716 0.96
93_V 412_V 1.702 0.96
40_D 149_F 1.701 0.96
38_L 49_E 1.698 0.96
885_C 893_Y 1.697 0.96
585_R 619_E 1.697 0.96
75_S 146_L 1.687 0.96
535_E 539_A 1.686 0.96
92_M 96_E 1.674 0.95
889_S 893_Y 1.672 0.95
889_S 892_K 1.671 0.95
885_C 898_G 1.666 0.95
64_I 92_M 1.663 0.95
79_F 146_L 1.653 0.95
25_V 29_N 1.651 0.95
887_C 892_K 1.649 0.95
62_N 65_P 1.637 0.95
24_V 65_P 1.634 0.95
889_S 897_H 1.631 0.94
601_D 604_S 1.617 0.94
545_H 549_L 1.616 0.94
47_T 50_F 1.613 0.94
885_C 892_K 1.6 0.94
239_V 310_V 1.599 0.94
445_R 452_V 1.599 0.94
745_E 749_R 1.595 0.94
67_A 117_Y 1.592 0.94
125_G 175_T 1.587 0.93
430_T 433_E 1.58 0.93
516_G 548_V 1.579 0.93
892_K 896_C 1.579 0.93
497_P 544_R 1.566 0.93
893_Y 898_G 1.565 0.93
61_E 95_N 1.563 0.93
797_K 802_E 1.561 0.93
556_I 575_S 1.553 0.92
164_P 168_E 1.551 0.92
164_P 167_R 1.545 0.92
519_W 523_V 1.545 0.92
44_K 149_F 1.539 0.92
889_S 898_G 1.532 0.92
28_I 92_M 1.532 0.92
436_Q 615_G 1.531 0.92
450_Q 583_S 1.522 0.91
395_D 411_V 1.52 0.91
438_I 559_T 1.52 0.91
444_E 448_K 1.508 0.91
50_F 54_L 1.507 0.91
35_M 66_E 1.506 0.91
542_Q 546_D 1.502 0.91
46_K 66_E 1.497 0.90
124_K 204_H 1.495 0.90
884_P 887_C 1.495 0.90
240_N 317_H 1.487 0.90
50_F 66_E 1.485 0.90
546_D 549_L 1.474 0.90
112_A 147_F 1.47 0.89
74_A 146_L 1.466 0.89
39_S 43_L 1.463 0.89
270_R 325_D 1.462 0.89
742_Q 745_E 1.456 0.89
882_N 885_C 1.456 0.89
34_E 46_K 1.455 0.89
32_E 76_K 1.452 0.89
435_I 465_V 1.449 0.88
444_E 447_A 1.448 0.88
880_G 883_D 1.445 0.88
75_S 83_H 1.444 0.88
429_M 608_R 1.443 0.88
792_R 806_E 1.439 0.88
884_P 889_S 1.437 0.88
890_G 893_Y 1.433 0.88
890_G 897_H 1.432 0.88
885_C 888_G 1.432 0.88
446_T 452_V 1.43 0.88
60_L 95_N 1.429 0.88
432_A 614_P 1.426 0.87
332_E 366_Q 1.419 0.87
182_Y 380_Y 1.418 0.87
124_K 385_E 1.417 0.87
34_E 38_L 1.415 0.87
533_Q 537_I 1.412 0.87
35_M 38_L 1.409 0.87
893_Y 897_H 1.409 0.87
621_P 625_K 1.406 0.86
890_G 898_G 1.405 0.86
60_L 204_H 1.404 0.86
86_V 415_N 1.402 0.86
34_E 37_K 1.402 0.86
491_V 556_I 1.401 0.86
47_T 67_A 1.399 0.86
782_M 807_S 1.39 0.86
496_Y 544_R 1.39 0.86
163_A 192_A 1.389 0.85
673_S 751_E 1.387 0.85
82_R 85_D 1.385 0.85
240_N 244_P 1.379 0.85
328_V 333_V 1.378 0.85
613_K 616_E 1.378 0.85
74_A 78_V 1.377 0.85
533_Q 536_K 1.374 0.85
267_E 596_R 1.373 0.85
887_C 894_K 1.371 0.84
29_N 82_R 1.36 0.84
145_P 148_E 1.359 0.84
522_E 544_R 1.357 0.84
890_G 894_K 1.355 0.83
51_R 122_T 1.35 0.83
885_C 894_K 1.348 0.83
464_L 468_E 1.347 0.83
882_N 894_K 1.347 0.83
93_V 410_V 1.343 0.83
886_P 897_H 1.343 0.83
477_N 499_A 1.33 0.82
886_P 889_S 1.327 0.82
442_I 469_L 1.327 0.82
88_L 114_L 1.322 0.81
888_G 896_C 1.321 0.81
681_E 740_L 1.319 0.81
595_M 623_V 1.319 0.81
192_A 198_R 1.318 0.81
782_M 803_Y 1.316 0.81
98_C 408_D 1.314 0.81
31_M 88_L 1.304 0.80
431_E 435_I 1.302 0.80
115_P 122_T 1.298 0.80
113_T 143_N 1.296 0.80
163_A 167_R 1.295 0.79
882_N 887_C 1.294 0.79
242_I 286_L 1.293 0.79
137_Q 141_E 1.284 0.79
889_S 894_K 1.282 0.79
70_V 150_L 1.279 0.78
129_V 208_V 1.275 0.78
886_P 896_C 1.275 0.78
436_Q 440_E 1.275 0.78
329_K 343_T 1.274 0.78
873_Q 878_K 1.272 0.78
493_Q 518_S 1.272 0.78
177_G 200_Q 1.269 0.78
122_T 385_E 1.268 0.77
682_D 819_K 1.268 0.77
239_V 282_I 1.267 0.77
327_I 336_V 1.262 0.77
53_R 57_G 1.26 0.77
83_H 91_G 1.256 0.77
22_R 85_D 1.255 0.76
439_I 472_A 1.254 0.76
88_L 92_M 1.253 0.76
731_H 734_T 1.251 0.76
884_P 890_G 1.248 0.76
208_V 387_L 1.247 0.76
240_N 362_G 1.246 0.76
28_I 31_M 1.246 0.76
125_G 204_H 1.244 0.76
439_I 468_E 1.243 0.75
892_K 897_H 1.241 0.75
605_G 609_K 1.238 0.75
884_P 896_C 1.237 0.75
51_R 121_L 1.235 0.75
426_L 585_R 1.235 0.75
892_K 898_G 1.234 0.75
167_R 171_A 1.229 0.74
334_I 345_Q 1.228 0.74
155_G 172_A 1.225 0.74
440_E 443_K 1.224 0.74
24_V 27_I 1.224 0.74
274_L 310_V 1.217 0.73
885_C 891_K 1.214 0.73
203_L 385_E 1.214 0.73
496_Y 547_A 1.212 0.73
895_Q 899_R 1.211 0.73
26_N 30_A 1.211 0.73
57_G 62_N 1.208 0.73
666_L 771_L 1.205 0.72
781_A 810_M 1.202 0.72
445_R 555_H 1.201 0.72
17_T 20_R 1.201 0.72
52_A 55_E 1.199 0.72
449_G 497_P 1.197 0.72
536_K 540_D 1.195 0.71
124_K 202_K 1.194 0.71
647_E 798_D 1.191 0.71
544_R 547_A 1.19 0.71
205_Y 388_A 1.184 0.70
477_N 483_F 1.182 0.70
436_Q 614_P 1.182 0.70
45_G 49_E 1.181 0.70
195_P 198_R 1.181 0.70
49_E 70_V 1.179 0.70
137_Q 158_L 1.179 0.70
162_P 165_A 1.177 0.70
888_G 893_Y 1.175 0.70
882_N 896_C 1.17 0.69
647_E 804_K 1.169 0.69
71_V 113_T 1.169 0.69
76_K 82_R 1.166 0.69
49_E 52_A 1.165 0.69
51_R 63_L 1.162 0.68
879_V 886_P 1.162 0.68
296_E 300_S 1.16 0.68
532_E 536_K 1.158 0.68
738_R 742_Q 1.156 0.68
31_M 35_M 1.155 0.68
886_P 890_G 1.155 0.68
242_I 282_I 1.153 0.67
68_F 91_G 1.151 0.67
30_A 65_P 1.149 0.67
416_R 419_I 1.148 0.67
677_N 748_Q 1.145 0.67
547_A 551_A 1.141 0.66
887_C 891_K 1.138 0.66
882_N 890_G 1.137 0.66
27_I 30_A 1.137 0.66
882_N 889_S 1.136 0.66
175_T 201_R 1.13 0.65
33_P 37_K 1.122 0.64
430_T 591_E 1.12 0.64
751_E 759_M 1.117 0.64
886_P 898_G 1.117 0.64
445_R 583_S 1.116 0.64
441_D 555_H 1.113 0.63
641_I 645_L 1.112 0.63
691_Y 705_G 1.109 0.63
886_P 893_Y 1.108 0.63
95_N 119_N 1.103 0.62
266_D 269_S 1.103 0.62
26_N 85_D 1.102 0.62
882_N 893_Y 1.101 0.62
153_T 172_A 1.098 0.62
464_L 467_N 1.096 0.62
91_G 114_L 1.095 0.62
677_N 744_I 1.093 0.61
125_G 201_R 1.092 0.61
239_V 243_I 1.091 0.61
881_R 885_C 1.09 0.61
89_L 92_M 1.089 0.61
50_F 63_L 1.088 0.61
882_N 888_G 1.087 0.61
75_S 78_V 1.085 0.60
605_G 608_R 1.083 0.60
435_I 461_K 1.081 0.60
262_H 277_R 1.081 0.60
29_N 32_E 1.08 0.60
891_K 896_C 1.075 0.59
168_E 171_A 1.072 0.59
49_E 53_R 1.068 0.59
749_R 753_V 1.067 0.59
514_V 575_S 1.067 0.59
31_M 34_E 1.066 0.58
514_V 545_H 1.065 0.58
203_L 380_Y 1.063 0.58
523_V 534_I 1.063 0.58
264_S 275_T 1.063 0.58
200_Q 384_Y 1.062 0.58
75_S 81_M 1.058 0.58
57_G 61_E 1.057 0.57
72_R 82_R 1.055 0.57
440_E 444_E 1.054 0.57
58_E 62_N 1.053 0.57
441_D 583_S 1.053 0.57
654_D 657_R 1.052 0.57
133_D 166_K 1.052 0.57
774_L 817_S 1.052 0.57
435_I 438_I 1.051 0.57
161_M 165_A 1.051 0.57
198_R 668_D 1.05 0.57
888_G 894_K 1.047 0.56
147_F 152_L 1.047 0.56
519_W 541_W 1.047 0.56
888_G 898_G 1.047 0.56
25_V 85_D 1.045 0.56
206_A 387_L 1.045 0.56
161_M 166_K 1.044 0.56
557_I 584_S 1.041 0.56
122_T 205_Y 1.041 0.56
476_H 500_V 1.04 0.56
427_V 627_I 1.038 0.55
744_I 748_Q 1.03 0.55
767_M 822_V 1.028 0.54
894_K 897_H 1.028 0.54
35_M 46_K 1.027 0.54
42_E 45_G 1.026 0.54
141_E 148_E 1.025 0.54
5_L 9_V 1.023 0.54
34_E 42_E 1.021 0.54
676_I 822_V 1.018 0.53
435_I 464_L 1.015 0.53
404_I 639_F 1.014 0.53
140_A 154_V 1.012 0.53
449_G 547_A 1.012 0.53
540_D 544_R 1.012 0.53
15_D 22_R 1.011 0.52
280_V 284_E 1.011 0.52
242_I 285_L 1.01 0.52
882_N 892_K 1.007 0.52
20_R 63_L 1.003 0.52
436_Q 468_E 1.002 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1nktA20.961000.105Contact Map0.669
2ipcA40.96451000.198Contact Map0.64
2fsfA20.94671000.353Contact Map0.724
1tf5A10.93341000.368Contact Map0.692
3juxA10.85681000.447Contact Map0.672
2eyqA20.61271000.886Contact Map0.388
4gl2A20.66261000.92Contact Map0.314
4bgdA10.75691000.926Contact Map0.26
1oywA10.55271000.93Contact Map0.507
3oiyA20.432999.90.938Contact Map0.487
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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